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肾多巴胺受体对血量扩张和脑室高张盐溶液注射引起促钠排泄的作用

徐尧君, 傅雷, 林茂樟

大连医科大学生理教研室. 辽宁, 大连 116027

摘要

观察麻醉兔用氟哌啶醇阻断肾多巴胺受体对血量扩张(VE)和脑室高张盐溶液注射(ICHNa)引起促钠排泄反应的影响。结果表明肾多巴胺受体阻断显著减弱VE以及VE+ICHNa引起 促钠排泄, 对ICHNa的反应无效; 在正常兔VE+ICHNa引起促钠排泄显著大于各单一刺激 的反应。

关键词： 促钠排泄; 利尿; 血量扩张; 脑室注射; 高张盐溶液; 肾多巴胺受体

The effect of renal dopamine receptor blockade on natriuresis induced by volume expansion and intracerebroventricular injection of hypertonic saline in rabbits

Xu Yaojun, Fu Lei, Lin Maozhang

Department of Physiology, Dalian Medical University. Dalian 116027, Liaoning

Abstract

In the VE experiments, Hal group decreases the peak increase of U_(Na) V from control group of 65.0±15.0 to 19.0±5.5#mu#mol/min(P<0.02). In the ICHNa experiments, the peak increase of U_(Na)V in control and Hal groups were respectively 28.9±4.6 and 29.0±5.8#mu#mol/min(P>0.50). In the experiments of rabbits with intact renal dopamine receptor, the natriuresis induced by VE+ICHNa was significantly greater than those due to either inducing factor acting alone. Renal dopamine receptor blockade also significantly attenuated the natriuresis induced by VE+ICHNa. These results indicate that renal dopamine receptor blockade significantly attenuated the natriuresis induced by VE+ICHNa, but did not affect the response of ICHNa.

Key words: Natriuresis;Diuresis;Volume expansion;Intracerebroventricular injection; Hypertonic saline;Renal dooamine receptor

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引用本文：

徐尧君, 傅雷, 林茂樟. 肾多巴胺受体对血量扩张和脑室高张盐溶液注射引起促钠排泄的作用[J]. 生理学报 1995; 47 (6): .

Xu Yaojun, Fu Lei, Lin Maozhang. The effect of renal dopamine receptor blockade on natriuresis induced by volume expansion and intracerebroventricular injection of hypertonic saline in rabbits. Acta Physiol Sin 1995; 47 (6): (in Chinese with English abstract).