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兴奋下丘脑弓状核神经元降低大鼠血浆唾液酸水平的作用

陈文芳, 陈家津, 陈蕾

青岛医学院生理学教研室. 山东, 青岛 266021

摘要

下丘脑弓状核(ARC)区注射谷氨酸钠(Glu)后, 血浆唾液酸(SA)水平较对照组明显降低 (P<0.01), 而且随Glu浓度的增加, 血浆SA水平降低所需的时间逐渐缩短; 侧脑室注射阿朴吗啡后, ARC区注射Glu, 血浆SA水平明显降低(P<0.01), 而且降低发生时间较对照组提前; 侧脑室注射螺哌啶酮后, ARC区注射Glu, 血浆SA水平无明显变化(P>0.05)。

关键词： 谷氨酸钠; 下丘脑; 弓状核区; 血浆; 唾液酸; 大鼠

Excitation of hypothalamic nucleus arcuatus neuron induced decrease of plasma sialic acid level in rats

Chen Wenfang, Chen Jiajin, Chen Lei

Department of Physiology, Qingdao Medical College. Qingdao 266021, Shandong

Abstract

The plasma SA level was significantly decreased after microinjection of Glu into the ARC (P<0.01). With increasing Glu concentration, the onset of the decrease occurred earlier. When Glu was microinjected into ARC after intraventricular injection of apomorphine, the plasma SA level was significantly decreased(P<0.01)and the time required to cause the decrease was shortened. When Glu was microinjected into ARC after intraventricular injection of spiperone, no change was found in the plasma SA level (P>0.05). It suggest that the mechanism underlying the decrease of plasma SA level is probably related to modulated dopamine (DA)release of hypothalamic dopaminergic neurons by DA-D2 receptor.

Key words: Sodium glutamate;Hypothalamus;Nucleus arcuatus;Plasma;Static acid;Rat

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引用本文：

陈文芳, 陈家津, 陈蕾. 兴奋下丘脑弓状核神经元降低大鼠血浆唾液酸水平的作用[J]. 生理学报 1995; 47 (6): .

Chen Wenfang, Chen Jiajin, Chen Lei. Excitation of hypothalamic nucleus arcuatus neuron induced decrease of plasma sialic acid level in rats. Acta Physiol Sin 1995; 47 (6): (in Chinese with English abstract).