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脑室注射白细胞介素1受体拮抗剂对抗束缚应激免疫抑制因子的产生

左永昌, 李怡风, 刘薇, 邓玉兰, 黄大无, 梅林, 范少光, 丁桂凤

北京医科大学免疫教研室. 北京 100083；北京医科大学生理教研室. 北京 100083

摘要

脑室注射白细胞介素1受体拮抗剂(IL-1Ra)能抑制束缚应激小鼠血清蛋白的产生, 并 呈量效关系。注射5.0#mu#g IL-1Ra时, 几乎完全对抗此蛋白的产生。脑室注射1pg IL-1#beta#对此蛋白的产生有增强作用; 腹腔注射IL-1#beta#或IL-1Ra, 均无影响, 表 明脑内IL-1在束缚应激血清抑制蛋白的产生过程中起有很重要的作用。

关键词： 束缚应激; 白细胞介素1受体拮抗剂(IL－1Ra); 淋巴细胞转化

Intracerebroventricular injection of interleukin I receptor antagonist antagonises on the generation of immuno-suppressive fator in restraint mice

Zuo Yongchang, Li Yifeng, Liu Wei, Deng Yulan, Huang Dawu, Mei Lin, Fan Shaoguang, Ding Guifeng

Department of Immunology, Beijing Medical University. Beijing 100083；China

Abstract

It was found that intracere broventricular (icv) injection of IL-1 receptor antagonist (IL-1Ra) was found capable of suppressing the production of such a serum protein under restraint stress. Nearly complete suppression could be achieved by 5.0#mu#g IL-1Ra. Intracerebroventricular injection of IL-1#beta# (1pg), however, increased the generation of the supressive protein. Neither intraperitoneal (ip) injection of Il-1Ra or IL-1#beta# had any effect on the generation of the protein. It suggest that IL-1 in brain might act as an important mediator between CNS and the immune system.

Key words: Restraint stress interleukin 1 (IL-1);Interleukin 1 receptor antagonist(IL-1Ra);Lymphocyte proliferation

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引用本文：

左永昌, 李怡风, 刘薇, 邓玉兰, 黄大无, 梅林, 范少光, 丁桂凤. 脑室注射白细胞介素1受体拮抗剂对抗束缚应激免疫抑制因子的产生[J]. 生理学报 1995; 47 (5): .

Zuo Yongchang, Li Yifeng, Liu Wei, Deng Yulan, Huang Dawu, Mei Lin, Fan Shaoguang, Ding Guifeng. Intracerebroventricular injection of interleukin I receptor antagonist antagonises on the generation of immuno-suppressive fator in restraint mice. Acta Physiol Sin 1995; 47 (5): (in Chinese with English abstract).