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水盐负荷改变时分泌心房钠尿肽的心房特殊颗粒数目与其钙含量的相关变化

俞彰, 钟慈声

上海医科大学生物物理学教研室. 上海 200032

摘要

禁水引起心房钠尿肽(ANP)分泌减少时, 心房特殊颗粒(ASG)的数密度增加(6.02±2.30增至9.97±3.21个/#mu#m~(3), 同时伴有钙含量增加(64±16增至92±18mmol/kg); 饮盐水引起ANP分泌增加时, ASG的数密度减少(6.02±2.30减至2.96±1.62个/#mu#m~(3), 且伴有钙含量减少(64±16减至38±22mmol/kg), 但水盐负荷对肌质网终末池(TSR)中钙浓度无任何影响。可推论ASG作为细胞内钙库, 借某种机制调控其中钙的释放而参与ANP的刺激分泌偶联过程。

关键词： 心房特殊颗粒; 禁水; 盐负荷; 细胞内钙库

Relative changes between calcium content and number of atrial specific granules induced by water and salt loading

Yu Zhang, Zhong Cisheng

Department of Biophysics, Shanghai Medical University. Shanghai 200032

Abstract

In the drinking 2% NaCl solution group, the Nv of ASG decreased from 6.02±2.30 to 2.96±1.62/#mu#m~(3)(P<0.01) and all companied by a decrease of Ca concentration from 64±16 to 38±21mmol/kg (P<0.01), while the secretion of atrial natriuretic peptide (ANP) showed some increase. Water deprivation induced all the contrary results. However, the Ca concentration in TSR was not affected by water-salt loading. It considered that ASG as an intracellular Ca store participates in the stimulus-secretion coupling of ANP through the release of Ca ions.

Key words: Atrial specific granule;Water-depriving;Salt-loading;Intracellular Ca store

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引用本文：

俞彰, 钟慈声. 水盐负荷改变时分泌心房钠尿肽的心房特殊颗粒数目与其钙含量的相关变化[J]. 生理学报 1995; 47 (5): .

Yu Zhang, Zhong Cisheng. Relative changes between calcium content and number of atrial specific granules induced by water and salt loading. Acta Physiol Sin 1995; 47 (5): (in Chinese with English abstract).