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交感神经对大鼠失血性休克过程中淋巴微循环的调控

张静, 刘艳凯, 张学锋, 薄爱华

张家口医学院病理生理教研室. 河北, 张家口 075029

摘要

去神经后大鼠肠系膜微淋巴管(ml)自主收缩频率及总收缩性指数、淋巴管动力学指数显著降低, 失血性休克时神经完整组及去神经组ML的自主收缩性均降低, 神经完整组在回输血液及输液期, ML自主收缩性显著高于休克前, 而去神经组的ML收缩性仍维持低水平, 且显著低于神经完整组(P<0.01)。输液后期, 去神经组的血压显著低于神经完整组。结果提示, 失 血性休克时, ML收缩性降低, 输血输液可提高ML收缩性及回升血压, 休克逆转的这些变化可能是依靠交感神经的调控实现的。图4表1参13

关键词： 交感神经; 失血性休克; 微循环; 淋巴; 收缩性

Modulation of lymph microcirculation by sympathetic nerve during hemorrhagic shock of rat

Zhang Jing, Liu Yankai, Zhang Xuefeng, Bo Aihua

Department of Pathophysiology, Zhangjiakou Medical College. Zhangjiakou 075209, Hefei

Abstract

The present study was undertaken to examine the effect of sympathetic nerve on the changes of lymph microcirculation during hemorrhagic shock. After greater splanchnic nerve transection, changes of contractility of mesenteric micro-lymphatics (ML) in denervated rat were visualized and recorded by using a vital microscope with Tv recorder during hemorrhagic shock and followed by refusion of withdrawn blood and infusion of saline. Results obtained showed that ML spontaneous contraction frequency, overall lymphatic contractile activity (Index Ⅱ) and lymphatic dynamics (L. D--Index) decreased significantly after denervation. The ML spontaneous contractility decreased during hemorrhagic shock both in the denervated group and the intact group. During refusion of withdrawn blood and infusion of normal saline periods, the ML spontaneous contractility in the intact group was significantly higher than that of the pre--shock period, but in the denervated group it remained at a level, lower than that of the intact group (P>0.01). During the post--infusion period the blood presssure was still much lower in the denervated than that of the intact group. The above results suggest that ML contract

Key words: Sympathetic nerve;Hemorrhagic shock;Microcirculation;Lymph;Contractility

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引用本文：

张静, 刘艳凯, 张学锋, 薄爱华. 交感神经对大鼠失血性休克过程中淋巴微循环的调控[J]. 生理学报 1995; 47 (2): .

Zhang Jing, Liu Yankai, Zhang Xuefeng, Bo Aihua. Modulation of lymph microcirculation by sympathetic nerve during hemorrhagic shock of rat. Acta Physiol Sin 1995; 47 (2): (in Chinese with English abstract).