过刊浏览

多巴胺参与P物质对胃肌电活动和胃运动的毒蕈碱抑制效应

荆浩, 林坤伟, 梅懋华

大连医科大学生理教研室. 辽宁, 大连 116023

摘要

观察到P物质的抑胃效应可分别被尾核注射P物质抗血清、P物质受体拮抗剂[Arg~(6), D-Trip~(7,9), MePhe~(8)]-SP_(6-11)以及多巴胺D_(2)受体阻断剂氟哌啶醇所消除; 尾核注射多巴胺对胃肌电快波和胃运动也有抑制作用, 且能被尾核注射氟哌啶醇以及阿托品所阻断。提出设想, 尾核P物质可能是通过多巴胺D_(2)受体兴奋胆碱能M受体实现其抑制胃肌电快波和胃运动的效应。图4表3参12

Participation of dopamine of the muscarinergic inhibitory effect of substance P on gastric myoelectric activity and motility

Jing Hao, Lin Kunwei, Mei Maohua

Department of Physiology, Dalian Medical University. Dalian 116023, Liaoning

Abstract

Our previous study showed that microinjection of substance P (SP) into caudate nucleus inhibits gastric myoelectric fast wave and gastric motility, an effect mediated by muscarinic receptor. The present investigation showed that this effects of SP could be blocked by coinjected SP antiserum or SP antagonist [Arg~(6), D--Trip~(7,9), MePhe~(8)]--SP_(6-11)or D_(2)dopamine antagonist haloperidol. In addition, microinjection of dopamine (DA) into caudate nucleus could also inhibit gastric fast wave and motility, an effect again being blockable by coinjected DA antagonist haloperidol or atropine. Thus, it appears that the muscarinergic inhibitory effect of SP on gastric fast wave and motility is mediated by D_(2) dopamine receptor.

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

荆浩, 林坤伟, 梅懋华. 多巴胺参与P物质对胃肌电活动和胃运动的毒蕈碱抑制效应[J]. 生理学报 1995; 47 (2): .

Jing Hao, Lin Kunwei, Mei Maohua. Participation of dopamine of the muscarinergic inhibitory effect of substance P on gastric myoelectric activity and motility. Acta Physiol Sin 1995; 47 (2): (in Chinese with English abstract).