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丹皮酚对NG108-15细胞电压门控K~(+), Na~(+), Ca~(2+)流的抑制

胡谦, 施玉liang

中科院上海生理研究所. 上海 200031

摘要

利用克隆系NG108-15细胞在膜片箝全细胞记录(whole-cell recording)下, 观察了丹皮酚(Paeonol, PA)对钾、钠和钙流的作用。结果表明, PA对延迟整流钾电流(I_(k))、钠电流(I_(Na))、T型和L型钙电流(I_(Ca), T; I_(ca), L)均有明显的抑制效应, 作用迅速(1min起效), 呈量-效关系, 有相当好的可逆性。图3参15

关键词： 丹皮酚; NG108－15细胞; 全细胞记录; 膜电流; 抑制

Inhibition of voltage-gated K~(+), Na~(+)and Ca~(2+)currents in neuroblastoma ×glima hybrid cells by paeonol

Hu Qian, Shi Yuliang

Shanghai Institute of Physiology, Chinese Academy of Science. Shanghai 200031

Abstract

Key words: Paeonol;NG108-15 cell;Whole cell recording;Membrane current;Inhibition

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引用本文：

胡谦, 施玉liang. 丹皮酚对NG108-15细胞电压门控K~(+), Na~(+), Ca~(2+)流的抑制[J]. 生理学报 1994; 46 (6): .

Hu Qian, Shi Yuliang. Inhibition of voltage-gated K~(+), Na~(+)and Ca~(2+)currents in neuroblastoma ×glima hybrid cells by paeonol. Acta Physiol Sin 1994; 46 (6): (in Chinese with English abstract).