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生长抑素对胃粘膜的保护作用可能与清除自由基有关

李铁, 张席锦

北京医科大学生理学系. 北京(100083)

摘要

生长抑素对大鼠冷冻-束缚应激性胃粘膜损伤具有明显的保护作用, 同时显著地抑制应激引起的胃粘膜丙二醛含量的升高。应激时大鼠胃粘膜内黄嘌呤氧化酶(XO)的活性增高, 同时谷胱甘肽过氧化物酶(GSH-Px)的活性降低, 但超氧化物歧化酶(SOD)的活性未见明显变化。生长抑素预处理可使应激时GSH-Px活性的降低恢复到正常水平, 但对XO和SOD未见明显影响。 结果提示, 生长抑素对应激性胃粘膜的保护作用似与增强胃粘膜对自由基的清除有关。表4 参14

关键词： 应激; 胃粘膜损伤; 生长抑素; 氧自由基; 谷胱苷肽过氧化物酶

Protective effect of somatostatin against stress injury of gastric mucosa may be related to the scavenge of free radicals

Li Tie, Zhang Xijin

Department of Physiology, Beijing Medical University. Beijing

Abstract

It was observed that somatostatin could significantly protect rat gastric mucosa from injury induced by cold-restraint stress and inhibit the stress induced increase of malonaldehyde(MDA)content. In the gastric mucosa of stress rats, the xanthine oxidase(XO)activity were increased and the glutathione peroxidase (GSH-Px)activity were decreased respectively, while the superoxide dismutase(SOD) activity showed no change. After pretreatment with somatostatin, the decrease of GSH-Px activity was significantly reversed, whereas XO and SOD activities were not significantly affected. The results show that the protective effect of somatostatin against the stress-induced injury of gastric mucosa may be related to an enhancement of the ability of gastric mucosa to scavenge oxygen-derived free radicals.

Key words: Stress;Gastric mucosal injury;Somatostatin oxygen-derived free radicals; Glutathione peroxidase;

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引用本文：

李铁, 张席锦. 生长抑素对胃粘膜的保护作用可能与清除自由基有关[J]. 生理学报 1994; 46 (4): .

Li Tie, Zhang Xijin. Protective effect of somatostatin against stress injury of gastric mucosa may be related to the scavenge of free radicals. Acta Physiol Sin 1994; 46 (4): (in Chinese with English abstract).