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大鼠脑室内注射氨甲酰胆碱对肾钠、钾、水排出的影响

姜春玲, 林茂樟

大连医科大学生理教研室. 辽宁,大连(116023)

摘要

在麻醉大鼠侧脑室注射胆碱能激动剂氨甲酰胆碱(CBC)引起显著的促钠排泄、促钾排泄和利 尿反应(P<0.05), 其中促钠排泄反应与剂量之间呈量效关系(r=0.9997,P<0.05)。由脑室注射CBC(2.74×10~(-3)μmol)引起的上述反应可以被胆碱能M受体阻断剂阿托品或N受体阻断剂六甲双胺预处理完全阻断(P<0.05)。CBC的肾脏效应也可被肾上腺素能α受体阻断剂酚妥拉明预处理所部分阻断(P<0.0 5)。结果表明脑室注射CBC引起的促钠排泄、促钾排泄和利尿反应是刺激了脑胆碱能M或N受体, 有部分效应可能继发刺激去甲肾上腺素能α受体。图4参15

关键词： 利尿; 促钠排泄; 促钾排泄; 脑胆碱能M受体; 脑胆碱能N受体; 胆碱能激动剂

The role of brain cholinergic system in renal sodium, potassium and water excretion in rats

Jiang Chunling, Lin Maozhang

Department of Physiology, Dalian Medical University. Dalian,Liaoning

Abstract

In anesthetized rats intracerebroventricular(i.c.v.)injection of cholinergic agonist carbachol induced significant natriuresis, kaliuresis and diuresis(P<0.05). Among them, the degree of natriuresis was changed with carbachol in a dose-dependent manner(r=0.9997, P<0.05). These responses were completely blocked by cholinergic M receptor antagonist atropine or N receptor antagonist hexamethonium pretreatment. Such effects of carbachol were inhibited in part by pretreatment with adrenergic alpha receptor antagonist phentolamine. These results indicate that the natriuresis, kaliuresis and diuresis induced by i.c.v. injection of carbachol were primarily mediated by both muscarinic and nicotinic receptors in the brain, while the effect was in part mediated secondarily via adrenergic alpha receptor.

Key words: Natriuresis;Kaliuresis;Diuresis;Cholinergic M receptors;Cholinergic N remptors;Cholinergic agonist

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引用本文：

姜春玲, 林茂樟. 大鼠脑室内注射氨甲酰胆碱对肾钠、钾、水排出的影响[J]. 生理学报 1994; 46 (4): .

Jiang Chunling, Lin Maozhang. The role of brain cholinergic system in renal sodium, potassium and water excretion in rats. Acta Physiol Sin 1994; 46 (4): (in Chinese with English abstract).