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刺激大鼠外侧缰核对脊髓背角神经元伤害性反应的影响

张一红, 程珍凤

西安医科大学生理教研室. 陕西,西安(710061)

摘要

电刺激大鼠一侧外侧缰核(LHb)可对脊髓背角广动力型(WDR)神经元的伤害性放电产生明显抑制; 这种抑制效应可部分地被iv赛庚啶及酚妥拉明所阻断; 电解损毁LHb对WDR神经元的放电无影响。结果表明: LHb参与了脊髓上结构对脊髓背角WDR神经元伤害性反应的下行抑制, 这种下行抑制为位相性抑制。图3表4参12

关键词： 外侧缰核; 脊髓背角广动力型神经元; 下行抑制

Effects of lateral harbenular stimulation on nociceptive response of neurons in rat spinal dorsal horn

Zhang Yihong, Cheng Zhenfeng

Department of Physiology, Xi^an Medical University. Xi^an.Shaanxi

Abstract

Ipsilateral stimulation of the LHb produced a significant attenuation of nociceptive response of wide dynamic range (WDR) neurons in the rat spinal dorsal horn. The inhibitory effect produced by LHb stimulation was partially blocked by systemic cyproheptadine and phentolamine but not naloxone. No significant change was observed in the activity of WDR neurons after ipsilateral electrolytical lesions of the LHb. These results suggest that the LHb participates in the supraspinal descending control on nociceptive response of WDR neurons in the spinal dorsal horn. However, tonic inhibitory mechanism seems not to be involved.

Key words: Lateral habenularnucleus;Spinal dorsal horn;Wide dynamic range neuron

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引用本文：

张一红, 程珍凤. 刺激大鼠外侧缰核对脊髓背角神经元伤害性反应的影响[J]. 生理学报 1994; 46 (4): .

Zhang Yihong, Cheng Zhenfeng. Effects of lateral harbenular stimulation on nociceptive response of neurons in rat spinal dorsal horn. Acta Physiol Sin 1994; 46 (4): (in Chinese with English abstract).