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侧脑室注射雨蛙肽对应激性胃粘膜损伤的影响

陈钢, 金泽重

延边医学院生理学教研室

摘要

侧脑室注射雨蛙肽(1.0ng/rat)可显著减轻大鼠胃粘膜损伤,抑制胃酸分泌,促进胃壁结合粘液分泌并使胃液中PGE_(2)含量增加。电镜观察可见胃壁细胞分泌增强。预先侧脑室注射纳洛酮或sc消炎痛可消除雨蛙肽抗胃粘膜损伤和抑制胃酸分泌的效应,但对胃壁结合粘液分泌无影响。侧脑室注射阿托品、酚妥拉明、心得安不影响雨蛙肽的抗损伤作用。结果提示,注射到侧脑室的雨蛙肽的抗胃粘膜损伤作用, 部分是通过中枢的吗啡受体和促进内源性PGE_(2)合成而实现的。图2表4参18

关键词： 雨蛙肽; 脑室; 胃粘膜; 应激; 胃液; 吗啡受体; 前列腺素

Effect of intracerebroventricular injection of caerulein on stress-induced gastric mucosal lesion in rats

Chen Gang, Jin Zezhong

Dept. Physiol., Yanbian Med. Coll.

Abstract

Key words: Caerulein;Cerebral ventricles;Gastric mucosa;Stress;Gastric juice;Morphine receptors;Prostaglandin

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引用本文：

陈钢, 金泽重. 侧脑室注射雨蛙肽对应激性胃粘膜损伤的影响[J]. 生理学报 1993; 45 (3): .

Chen Gang, Jin Zezhong. Effect of intracerebroventricular injection of caerulein on stress-induced gastric mucosal lesion in rats. Acta Physiol Sin 1993; 45 (3): (in Chinese with English abstract).