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急性低氧下#beta#-内啡肽参与对大鼠体液免疫的抑制性调节

白海波, 杜继曾, 郑筱祥

浙江大学生命科学与医学工程学系.浙江,杭州 310027；浙江大学生命科学与技术系.浙江,杭州 310027

摘要

正常大鼠脑室注射#beta#-内啡肽(#beta#-EP)(1ng/rat)使溶血素生成和鸡卵白蛋白的IgG抗体产生受到明显抑制,脾脏单个核细胞DNA含量也下降;7km 48h低氧同样使溶血素的产生明显下降,大鼠脑室注射阿片受体阻断剂钠屈酮可使低氧造成的IgG和溶血素生成抑制翻转,低氧抑制的脾脏单个核细胞DNA合成得到部分阻断;脑室注射#beta#-EP与7km低氧12h一样使脾脏中儿茶酚胺含量增加。

关键词： 低氧; 免疫; β-内啡肽; 免疫调节

#beta#-endorphin involved in the regulation of humoral immune function of rats during acute hypoxia

Bai Haibo, Du Jizeng, Zhang Xiaoxiang

Department of Biological Science and Medical Engineering,Zhejiang University.Hangzhou 310027,Zhejiang；China

Abstract

It was found that after rats received icv injection of #beta#-endorphin (1ng/rat), the T-lymphocyte DNA content, the hemolysin-forming capacity of SRBC-sensitized rats and the IgG level were reduced significantly compared with the control (icv normal saline). Similar suppressive effects on immune function could be found after rats were exposed to 7 km altitude in a hypobaric chamber for 48 h. Pretreatment with icv injection of naltrexone, the immunosuppressive effects of acute hypoxia were partially blocked. Icv administration of #beta#-endorphin produced an increased in splenic cathcholamines, similar to those of hypoxia treated group.

Key words: Hypoxia;Immunofunction;#beta#-endorphin;Immunoregulation

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引用本文：

白海波, 杜继曾, 郑筱祥. 急性低氧下#beta#-内啡肽参与对大鼠体液免疫的抑制性调节[J]. 生理学报 1999; 51 (3): .

Bai Haibo, Du Jizeng, Zhang Xiaoxiang. #beta#-endorphin involved in the regulation of humoral immune function of rats during acute hypoxia. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).