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内源性CO对内皮素促大鼠主动脉平滑肌细胞增殖及MAPK活性的影响

欧和生, 严丽梅, 符民桂, 王晓红, 庞永政, 苏静怡, 唐朝枢

北京医科大学第一临床医院心血管研究所.北京 100034；衡阳医学院内基诊断学教研室.湖南,衡阳 421001

摘要

ET-1刺激VSMC增殖伴有HO/CO的上调;抑制HO活性或阻断CO的产生将促进细胞的增殖反应,而HO活性的诱导或CO产生增加能有效抑制细胞的增殖反应;这些效应可能由MAPK信号途径所介导。

关键词： 血色素加氧酶; 一氧化碳; 血管平滑肌细胞; 丝裂素活化蛋白激酶

The role of endogenous CO in the regulation of endothelin-induced VSMC proliferation and MAPK activity

Ou Hesheng, Yan Limei, Fu Mingui, Wang Xiaohong, Pang Yongzheng, Su Jingyi, Tang Chaoshu

Institute of Vascular Research,the First Clinical Hospital,Beijing Medical University.Beijing 100034

Abstract

This study demonstrated that up-regulation of VSMC endogenous HO represents a cellular protective response to stress or injury. Inhibition of HO may enhance VSMC proliferation induced by ET-1 in vitro, suggesting that endogenous HO/CO system may be directly involved in the regulation of VSMC proliferation through MAPK signaling pathway.

Key words: Heme oxygenase;Carbon monoxide;Mitogen activated protein kinase;Vascular smooth muscle cell proliferation

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引用本文：

欧和生, 严丽梅, 符民桂, 王晓红, 庞永政, 苏静怡, 唐朝枢. 内源性CO对内皮素促大鼠主动脉平滑肌细胞增殖及MAPK活性的影响[J]. 生理学报 1999; 51 (3): .

Ou Hesheng, Yan Limei, Fu Mingui, Wang Xiaohong, Pang Yongzheng, Su Jingyi, Tang Chaoshu. The role of endogenous CO in the regulation of endothelin-induced VSMC proliferation and MAPK activity. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).