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缓激肽抑制麻醉大鼠颈动脉窦压力感受器反射

武宇明, 何瑞荣

河北医科大学基础医学研究所生理室.河北,石家庄 050017

摘要

在36只隔离灌流左侧颈动脉窦区的麻醉大鼠上观察了缓激肽(BK)对颈动脉窦压力感受器反射的影响。结果表明:BK对大鼠颈动脉窦压力感受器反射有抑制作用,此作用系BK引起血管内皮细胞生成NO所致。

关键词： 缓激肽; 颈动脉窦; 压力感受器反射; 平均动脉压; 窦内压

Bradykinin inhibits carotid sinus baroreflex in anesthetized rats

Wu Yuming, He Ruirong

Department of Physiology,Institute of Basic Medicine,Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The effects of bradykinin (BK) on the carotid baroreflex were examined in 36 anesthetized rats with isolated carotid sinus perfusion. The results indicated that BK may cause vascular endothelium to release NO, thereby inhibiting the carotid baroreflex.

Key words: Bradykinin;Carotid sinus;Baroreflex;Mean arterial pressure;Intrasinus pressure

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引用本文：

武宇明, 何瑞荣. 缓激肽抑制麻醉大鼠颈动脉窦压力感受器反射[J]. 生理学报 1999; 51 (3): .

Wu Yuming, He Ruirong. Bradykinin inhibits carotid sinus baroreflex in anesthetized rats. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).