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NMDA受体在海马CA_(3)区习得性LTP保持中的作用

梁伟国, 许世彤, 区英琦

华南师范大学神经生理研究室

摘要

在习得性长时程突触增强(LTP)刚形成及保持的情况下, 于每单元训练前微量注射NMDA受体 的特异性拮抗剂2-amino-5-phosphonovaleric acid (APV)于大鼠海与CA_(3)区, 观察对习得性LTP保持及习得性行为的影响。结果表明: NMDA受体在习得性LTP的巩固中起着重要作用。图5参13

关键词： 长时程突触增强; NMDA受体; 2-amino-5-phosphenovaleric acid; 海马; 明暗分辨学习; 大鼠

Role of N-methyl-D-aspartate receptor in the maintenance of learning-dependent long-term potentiation in rat hippocampal CA_(3) area

Liang Weiguo, Xu Shitong, Ou Yingqi

Neurophysiol. Res. Lab., S China Norm. Univ.

Abstract

Key words: Long-term potentiation;N-methyl-D-aspartate receptor;2-amino-5-phosphonovaleric acid;Hippocampus;Discrimination learning;Rat

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引用本文：

梁伟国, 许世彤, 区英琦. NMDA受体在海马CA_(3)区习得性LTP保持中的作用[J]. 生理学报 1992; 44 (4): .

Liang Weiguo, Xu Shitong, Ou Yingqi. Role of N-methyl-D-aspartate receptor in the maintenance of learning-dependent long-term potentiation in rat hippocampal CA_(3) area. Acta Physiol Sin 1992; 44 (4): (in Chinese with English abstract).