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冷适应大鼠脑垂体、下丘脑、脾淋巴细胞和血浆β-内啡肽及其mRNA的变化

徐扬, 杨泽田, 苏成芝

第四军医大学分子生物学研究室

摘要

冷暴1wk时, SD雄性大鼠垂体β-内啡肽(β-EP)mRNA明显增加, 从而激活细 胞免疫功能。免 疫中枢下丘脑和淋巴细胞(LC)β-EPmRNA在冷适应建立(冷暴2wk) 时增加。血浆β-EP从冷暴2wk起持续增加, 增强细胞免疫功能。虽然LC和血浆β -EP产物增加, 但垂体β-EP mRNA量从 冷暴2wk起恢复到对照组水平, 很可能是 通过LC-垂体-下丘脑轴, 信息反馈到中枢神经系统 造成的。图7参21

关键词： 冷适应; 垂体; 下丘脑; 淋巴细胞; 血浆; β-内啡肽; mRNA

Changes of β-endorphin and its messanger RNA in pituitary, hypothalamus, lymphocytes and blood plasma during cold acclimation of rats

Xu Yang, Yang Zetian, Su Chengzhi

Mol. Biol. lab., 4th Mil. Med. Coll.

Abstract

Key words: Cold acclimation;Pituitary;Hypothalamus;Lymphocyte;Blood plasma;Beta-endorphia;mRNA

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引用本文：

徐扬, 杨泽田, 苏成芝. 冷适应大鼠脑垂体、下丘脑、脾淋巴细胞和血浆β-内啡肽及其mRNA的变化[J]. 生理学报 1992; 44 (1): .

Xu Yang, Yang Zetian, Su Chengzhi. Changes of β-endorphin and its messanger RNA in pituitary, hypothalamus, lymphocytes and blood plasma during cold acclimation of rats. Acta Physiol Sin 1992; 44 (1): (in Chinese with English abstract).