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谷氨酸钠兴奋室旁核引起的升压效应及其与蓝斑-升压反应和A_(1)-降压 反应间的关系

常彦忠, 顾蕴辉

北京医科大学生理教研室

摘要

将L-谷氨酸钠(Glu)注入乌拉坦麻醉、箭毒化、人工呼吸大鼠的室旁核(NPV) 或蓝斑内引起升压反应。蓝斑升压反应可被双侧室旁核内预先注射酚妥 拉明或 心得安明显衰减; 双侧室旁核内预先注射酚妥拉明或荷包牡丹碱还可使Glu兴奋 延髓A_(1)区引起的降压反应减小, 但 注射心得安对A_(1)-降压反应无明 显影响。提示蓝斑-升压反应和A_(1)-降压反应均 部分通过NPV实现, A_ (1)降压过程中可能有NPV内GABA能抑制性中间神经元参与。图5表2参19

关键词： 室旁核; 蓝班; A_(1)区; 酚妥拉明; 心得安; 荷包牡丹碱; 大鼠

Pressor response to glutamate-injection into hypothalamic paraventricular nucleus and its relation to pressor response of locus coeruleus and depressor response of A_(1)

Chang Yanzhong, Gu Yunhui

Dept. Physiol., Beijing Med. Univ.

Abstract

Key words: Hypothalamic paraventricular nucleus;Locus coeruleus;A_(1) area;Phentolamine;Propranolol;Bicuculline;Rat

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引用本文：

常彦忠, 顾蕴辉. 谷氨酸钠兴奋室旁核引起的升压效应及其与蓝斑-升压反应和A_(1)-降压 反应间的关系[J]. 生理学报 1992; 44 (1): .

Chang Yanzhong, Gu Yunhui. Pressor response to glutamate-injection into hypothalamic paraventricular nucleus and its relation to pressor response of locus coeruleus and depressor response of A_(1). Acta Physiol Sin 1992; 44 (1): (in Chinese with English abstract).