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霉菌毒素Dihydroxyaflavinine非竞争性抑制在爪蟾卵母细胞内表达的GABA_(A)受体通道

姚永, 李永新

中国科学院上海生理研究所

摘要

将鸡脑mRNA注入爪蟾X. laevis卵母细胞表达得到GABA_(A)受体通道, Dihydroxyaflavinine非竞争性阻断GABA电流反应, 撤药后反应迅速恢复。青霉素对GABA_(A)受体的抑制作用随GABA浓度的升高而增加。浓度高达1μmol/L苯二氮[艹卓]位点配体Ro 15-1788不能阻断10μmol/L dihydroxyaflavinine的作用。Dihydroxyaflavinine类似印防己毒素, 表观上加速GABA_(A)受体的脱敏过程, 而青霉素和荷包牡丹碱与此相反。图4表1参22

关键词： Dihydroxyaflavinine; GABA_(A) 受体; 爪蟾卵母细胞; mRNA 表达

Fungal toxin dihydroxyaflavinine inhibits non-competitively GABA_(A) receptor channel expressed in Xenopus oocytes

Yao Yong, Li Yongxin

Shanghai Inst. Physiol., Acad. Sin.

Abstract

Key words: Dihydroxyaflavinine;GABA_(A) receptor;Xenopus oocyte;mRNA expression

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引用本文：

姚永, 李永新. 霉菌毒素Dihydroxyaflavinine非竞争性抑制在爪蟾卵母细胞内表达的GABA_(A)受体通道[J]. 生理学报 1991; 43 (3): .

Yao Yong, Li Yongxin. Fungal toxin dihydroxyaflavinine inhibits non-competitively GABA_(A) receptor channel expressed in Xenopus oocytes. Acta Physiol Sin 1991; 43 (3): (in Chinese with English abstract).