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大鼠胸腺细胞糖皮质激素受体结合与糖皮质激素效应的定量关系

隋黎明, 徐仁宝

第二军医大学病理生理教研室

摘要

在地塞米松(Dex)10~(-9)—10~(-5)mol/L浓度范围内, Dex大鼠胸腺细胞糖皮质激素受体(GR)的特异结合与Dex抑制细胞尿嘧啶核苷参入效应呈正向平行趋势。用RU486阻断5×10~(-8)mol/L浓度的Dex与GR 结合的不同分数, 发现Dex特异结合与抑制效应呈线性正相关(P<0.01)。将Dex结合-效应直线外推, 结果提示GR有约20%的占领阈, 但几乎没有备用受体。图5表1参14

关键词： 糖皮质激素受体; 糖皮质激素; 结合; 生物效应; 备用受体; 占领阈

A quantitative study on the relationship between the specific binding of glucocorticoid receptor and glucocorticoid biopotency in rat thymocytes

Sui Liming, Xu Renbao

Dept. Pathol. Physiol., 2d Mil. Med. Coll.

Abstract

Key words: Glucocorticoids;Glucocrticoid receptor;Binding;Biopotency;Spare receptor;Threshold receptor occupancy

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引用本文：

隋黎明, 徐仁宝. 大鼠胸腺细胞糖皮质激素受体结合与糖皮质激素效应的定量关系[J]. 生理学报 1991; 43 (3): .

Sui Liming, Xu Renbao. A quantitative study on the relationship between the specific binding of glucocorticoid receptor and glucocorticoid biopotency in rat thymocytes. Acta Physiol Sin 1991; 43 (3): (in Chinese with English abstract).