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大鼠再生肝抗CCl_(4)损伤与其线粒体呼吸活性变化的关系

张宝弘, 沈杰

大连医学院生理教研室

摘要

观察了肝部分切除(68%)后96h大鼠再生肝的抗CCl_(4)损伤作用, 并用氧电极法测定了再生肝线粒体的呼吸活性。结果如下: (1)CCl_(4)(50%, 10ml/kg)引起的动物死亡率, 肝 切除组大鼠较假手术组明显降低; (2)CCl_(4)(50%, 5ml/kg)损伤后, 肝切除组大鼠血清胆红素、血清谷丙转氨酶(sGPT)均明显低于假手术组, 组织学检查损伤程度也明显减轻; (3)无论是否伴有CCl_(4)损伤, 肝切除组大鼠肝线粒体的呼吸活性均强于假手术组, 且肝 线粒体呼吸活性的变化与血清胆红素、sGPT及肝组织损伤程度的改善是一致的。结果提示: 再生肝线粒体呼吸活性增高, 同时不易受CCl_(4)损伤, 可能在再生肝抗CCl_(4)损伤机制中起一定作用。图3表1参16

关键词： 再生肝; 四氯化碳; 肝保护; 线粒体

The relationship between protection of regenerating rat liver against carbon tetrachloride and change of its mitochondrial respiratory activity

Zhang Baohong, Sheng Jie

Dept. Physiol., Dalian Med. Coll.

Abstract

Key words: Regenerating liver;Carbon tetrachloride;Protection;Mitochondria

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引用本文：

张宝弘, 沈杰. 大鼠再生肝抗CCl_(4)损伤与其线粒体呼吸活性变化的关系[J]. 生理学报 1991; 43 (1): .

Zhang Baohong, Sheng Jie. The relationship between protection of regenerating rat liver against carbon tetrachloride and change of its mitochondrial respiratory activity. Acta Physiol Sin 1991; 43 (1): (in Chinese with English abstract).