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颈动脉内注入腺苷对呼吸、血压和肾交感神经活动的影响

苏欣, 张万育, 何瑞荣

河北医学院基础医学研究所

摘要

颈动脉内注入腺苷后, 平均动脉压呈剂量依赖性下降, 呼吸加快, 深度变化 不明显, 剪断窦神经后注入腺苷, 仍引起平均动脉压下降, 而呼吸变化消失; 隔离的颈动脉窦灌流液内加入腺苷后, 平均动脉压下降, 心率减慢, 颈动脉体(CB) 失活后反应消失; 将腺苷灌注到颈动脉窦区后, 平均动脉压下降, 肾交感神经传 出放电活动增加, CB失活或剪断窦神经后, 反应消失。提示腺苷可作为兴奋CB 的一种物质, 引起平均动脉压降低, 心率减慢, 呼吸加强和肾交感神经放电活动 增加。图3表3参21

关键词： 腺苷; 颈动脉体; 平均动脉压; 心率; 呼吸; 肾交感神经活动

Effects of intracarotid injection of adenosine on respiration blood pressure and renal sympathetic nerve activity

Su Xin, Zhang Wanyu, He Ruirong

Inst. Bas. Med., Hebei Med. Coll.

Abstract

In response to intracarotid injections of adenosine, MAP decreased in a dose-dependent manner, while the frequency of respiration increases with litttle change in depth. Following carotid sinus denervation, intracarotid injection of adenosine still resulted in a decrease of MAP but with no changes in respiration. By adding adenosine to perfusate of the isolated carotid sinus, both MAP and HR decreased, but these effects could be abolished by inactivation of carotid body. MAP decreased and RSNA enhanced during perfusing adenosine into carotid sinus. These effects couldbe abolished by the section of sinus nerve or inactivation of CB. It is considered that adenosine is capable of activating CB, decreasing MAP and heart rate but with a concomitant increases in respiration and RSNA.

Key words: Adenosine;Carotid body;Mean arterial blood pressure;Heart rate;Respiration;Renal sympathetic nerve activity

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引用本文：

苏欣, 张万育, 何瑞荣. 颈动脉内注入腺苷对呼吸、血压和肾交感神经活动的影响[J]. 生理学报 1991; 43 (2): .

Su Xin, Zhang Wanyu, He Ruirong. Effects of intracarotid injection of adenosine on respiration blood pressure and renal sympathetic nerve activity. Acta Physiol Sin 1991; 43 (2): (in Chinese with English abstract).