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Recent advances in non-coding RNA-mediated PI3K/AKT/mTOR signaling pathway regulation involved in triple-negative breast cancer pathogenesis and progression

HUANG Zhu^1,2,*, LI Wen-Jing¹, SONG Zi-Juan¹, HUANG Si-Yi¹, YANG Zi-Qing¹, CHU Ya-Ya³, DING Fu-Sheng¹, LI Cong-Hu¹

¹Innovation Center of Targeted Development of Medicinal Resources, School of Life Sciences and Food Engineering, Anqing Normal University, Anqing 246133, China；²Anhui Provincial Key Laboratory of Biodiversity Conservation and Characteristic Resource Utilization in Southwest Anhui, School of Life Sciences and Food Engineering, Anqing Normal University, Anqing 246133, China；³Anhui Huiyueji Food Co., Ltd., Anqing 246600, China

Abstract

Triple-negative breast cancer (TNBC) is characterized by high invasion and metastasis, poor prognosis, and high mortality, making it the most aggressive form of breast cancer. Currently, there is still a lack of effective therapeutic targets for TNBC. Aberrant activation of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is prevalent in TNBC, leading to increased resistance to chemotherapeutic agents and poor prognosis. Non-coding RNA (ncRNA), including microRNA (miRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA), are involved in a variety of biological processes and can be used as oncogenes or tumor suppressor genes to regulate the PI3K/AKT/mTOR pathway to promote or inhibit the occurrence and development of TNBC. This article reviews some important miRNA, lncRNA, circRNA, and their targets and molecular mechanisms that regulate the PI3K/AKT/mTOR pathway in TNBC, hoping to open up new avenues for the research of TNBC and ultimately promote the development of precise and effective treatments for TNBC.

Key words: triple-negative breast cancer; PI3K/AKT/mTOR pathway; miRNA; lncRNA; circRNA

Received: 　　Accepted:

Corresponding author: 黄祝　　E-mail:

DOI: 10.13294/j.aps.2025.0109

Citing This Article：

HUANG Zhu, LI Wen-Jing, SONG Zi-Juan, HUANG Si-Yi, YANG Zi-Qing, CHU Ya-Ya, DING Fu-Sheng, LI Cong-Hu. Recent advances in non-coding RNA-mediated PI3K/AKT/mTOR signaling pathway regulation involved in triple-negative breast cancer pathogenesis and progression. Acta Physiol Sin 2026; 78 (2): 315-330 (in Chinese with English abstract).