Acta Physiologica Sinica

Yongsheng Chang

Department of Physiology and Pathophysiology, Tianjin Medical University
Contact information
22 Qi Xiang Tai Lu, Tianjin, China

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2002-2006, Postdoc, Department of Medicine, NJC, Denver, CO, USA
1999-2002, Department of Biochemistry, Peking Union Medical College, Ph.D.
1996-1999, Department of Biochemistry, Hubei University, M.S.
1992-1996, Department of Biochemistry, Hubei University, B.S.
2017-present, Professor, Department of Physiology and Pathophysiology, Tianjin Medical University
2006-2017, Professor, Department of Biochemistry, Peking Union Medical College

HONORS, PRIZES AND AWARDS
2015 Young talent in science and technology innovation leader, Ministry of Science and Technology, China
2018 National Science Found for Distinguished Young Scholars of China

SELECTED PUBLICATIONS

Anfang Cui, Heng Fan, Yinliang Zhang, Yujie Zhang, Dong Niu, Shuainan Liu, Quan Liu, Wei Ma, Zhufang Shen, Lian Shen, Yanling Liu, Huabing Zhang, Yuan Xue, Ying Cui, Qinghua Wang, Xinhua Xiao, Fude Fang, Jichun Yang, Qinghua Cui, Yongsheng Chang*. Dexamethasone-induced Krüppel-like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia. J Clin Invest, 2019 Apr 29;129(6):2266-2278
Lu Yao, Xiaona Cui, Qi Chen, Xiaoying Yang, Fude Fang, Jun Zhang, Guoqing Liu, Wanzhu Jin, Yongsheng Chang*. Cold-inducible SIRT6 regulates thermogenesis of brown and beige fat. Cell Reports, 2017;20(3):641-654
Yang X, Chen Q, Sun L, Zhang H, Yao L, Cui X, Gao Y, Fang F, Chang Y. KLF10 transcription factor regulates hepatic glucose metabolism in mice. Diabetologia, 2017;60(12):2443-2452
Ying Cui, Aijun Qiao, Tao Jiao, Huabing Zhang, Yuan Xue, Yongkang Zou, Anfang Cui, Fude Fang, Yongsheng Chang*. Hepatic Forkhead Box Q1 (FOXQ1) Transcription Factor Regulates Glucose metabolism. Diabetologia, 2016;59(10):2229-2239
Huabing Zhang, Qi Chen, Min Yang, Bin Zhu, Ying Cui, Yuan Xue, Nin Gong, Anfang Cui, Min Wan, Lian Shen, Shutian Zhang, Fude Fang, Yongsheng Chang*. Mouse KLF11 regulates hepatic lipid metabolism. Journal of Hepatology, 2013;58(4):763-770
Aijun Qiao, Jichao Liang, Yaojun Ke, Chenghong Li, Yin Cui, Lian Shen, Huabing Zhang, Anfang Cui, Xiaojun Liu, Changzheng Liu, Yong Chen, Yi Zhu, Youfei Guan, Fude Fang, Yongsheng Chang*. Mouse PNPLA3 influences systemic lipid and glucose homeostasis. Hepatology, 2011;54(2):509-521

Lihong Chen

Professor, Advanced Institute for Medical Sciences, Dalian Medical UniversityEmail: bjclh2000@163.com
Tel: 18519254416
Address: 9 W.S. Lvshun Blvd, Dalian, China, 116044

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2004.09-2009.07 PhD, Department of Physiology and Pathophysiology, Peking University (Mentor: Prof. Youfei Guan)
1999.09-2004.07 MD, Department of Clinical Medicine, Shanxi Medical University
2016.03-now Professor, Dalian Medical University
2014.07-2016.02 Research Associate, University of Pennsylvania, USA
2009.07-2014.06 Postdoctoral fellow, University of Pennsylvania, USA

HONORS, PRIZES AND AWARDS
• 2018 Distinguished Professor of Liaoning Province
• 2018 “Qian” level of “Liaoning BaiQianWan Talents Program”
• 2017 Local Leading Talents in Dalian
• 2015 Certificate of Research Excellence, American Heart Association
• 2012 Young Investigator Award, International Winter Eicosanoid Conference

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS
Frontiers in Pharmacology (Editorial Board)
Journal of Pharmacological Reports (Editorial Board)
PPAR Research (Guest Editor, 2013-14)
Scientific Reports (Editorial Board)
Acta Physiologica Sinica (Editorial Board)
National Natural Science Foundation of China
Frontiers in Pharmacology
Current Vascular Pharmacology
Clinical and Experimental Pharmacology and Physiology
Journal of Chemistry
Journal of Pharmacological Reports
Journal of Traditional Chinese Medical Sciences
Life Sciences
Mediators of Inflammation
Pharmacological Research
Plos One
PPAR Research
Scientific Reports
Chinese Journal of Biochemistry Molecular Biology

SELECTED PUBLICATIONS

Jia-Yang Zhang, Shuang Ji, Li-Hong Chen*, Guang-Rui Yang*. Recent advances in renal biological clock. Progress in Physiological Sciences 2019;50(5):386-390
Ting-Ting Jiang#, Shuang Ji#, Guang-Rui Yang, Li-Hong Chen*. Research advances in relationship between biological clock and cardiovascular diseases. Acta Physiologica Sinica 2019;71(05):783-791
Lihong Chen, Guangrui Yang, Tingting Jiang, Soonyew Tang, Tao Wang, Qing Wan, Miao Wang, Garret A. FitzGerald. Myeloid cell mPges-1 deletion attenuates mortality without affecting remodeling after acute myocardial infarction in mice. J Pharmacol Exp Ther. 2019;370(1):18-24
Guangrui Yang*, Lihong Chen*, Jiayang Zhang, Baoyin Ren, Garret A FitzGerald. Bmal1 deletion in mice facilitates adaptation to disrupted light/dark conditions. JCI Insight 2019 Apr 11;5(10):e125133
Hu Xu, Shengnan Du, Bingying Fang, Chaojie Li, Xiao Jia, Wen Su, Nanping Wang, Feng Zheng, Lihong Chen, Xiaoyan Zhang, JÅ Gustafsson, Youfei Guan. VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure. Proc Natl Acad Sci USA 2019 Apr 23;116(17):8457-8462
Lihong Chen, Guangrui Yang, Jiayang Zhang, Baoyin Ren, Soonyew Tang, Xuanwen Li, Garret A FitzGerald. Time-dependent hypotensive effect of aspirin in mice. Arterioscler Thromb Vasc Biol 2018;38:2819-2826
Hu Hua, Xuhua Ge, Mengqiu Wu, Chunhua Zhu, Lihong Chen, Guangrui Yang, Yue Zhang, Songming Huang, Aihua Zhang, Zhanjun Jia. Rotenone protects against acetaminophen induced kidney injury by attenuating oxidative stress and inflammation. Kidney Blood Press Res 2018 Aug 10;43(4):1297-1309
Jie Yin, Weiwei Xia, Yue Zhang, Guixia Ding, Lihong Chen, Guangrui Yang, Songming Huang, Zhanjun Jia, Aihua Zhang. Role of dihydroartemisinin in regulating prostaglandin E2 synthesis cascade and inflammation in endothelial cells. Heart Vessels. 2018 Nov;33(11):1411-1422
Yibo Zhuang, Chenhu Wang, Chunfeng Wu, Dan Ding, Fei Zhao, Caiyu Hu, Wei Gong, Guixia Ding, Yue Zhang, Lihong Chen, Guangrui Yang, Chunhua Zhu, Aihua Zhang, Zhanjun Jia, Songming Huang. Mitochondrial oxidative stress activates COX-2/mPGES-1/PGE2 cascade induced by albumin in renal proximal tubular cells. Oncotarget 2018 Jan 12;9(10):9235-9245
Jing Wang, Min Liu, Xiaoyan Zhang, Guangrui Yang, Lihong Chen#. Physiological and pathophysiological implications of PGE2 and the PGE2 synthases in the kidney. Prostaglandins Other Lipid Mediat 2018 Jan;134:1-6
Carsten Skarke, Nicholas F. Lahens, Seth D. Rhoades, Amy Campbell, Kyle Bittinger, Aubrey Bailey, Christian Hoffmann, Randal S. Olson, Lihong Chen, Guangrui Yang, Thomas S Price, Jason H Moore, Frederic D Bushman, Casey S Greene, Gregory R Grant, Aalim M Weljie, Garret A FitzGerald. A Pilot Characterization of the Human Chronobiome. Sci Rep 2017 Dec 7;7(1):17141
Wen Su, Shizheng Huang, Min Gao, Xiaomu Kong, Jan-Åke Gustafsson, Sujuan Xu, Bing Wang, Feng Zheng, Lihong Chen, Nanping Wang, Youfei Guan, Xiaoyan Zhang. Liver X receptor β (LXRβ) increases AQP2protein Level via a post-transcriptional mechanism in renal collecting ducts. Am J Physiol Renal Physiol 2017 Apr 1;312(4):F619-F628
Lihong Chen#. Current trends in PGE2 targeting for anti-inflammatory therapy. Pharm Bioprocess 2016;4(3):048-049
Guangrui Yang, Lihong Chen#. An update of microsomal prostaglandin E synthase (mPGES)-1 and PGE2 receptors in cardiovascular health and diseases. Oxid Med Cell Longev 2016;2016:5249086
Soon Yew Tang, James Monslow, Gregory R Grant, Leslie Todd, Sven-Christian Pawelzik, Lihong Chen, John Lawson, Ellen Puré, Garret A FitzGerald. Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice. Circulation 2016 Jul 26;134(4):328-38
Guangrui Yang*, Lihong Chen*, Gregory R Grant, Georgios Paschos, Wen-Liang Song, Erik S Musiek, Vivian Lee, Sarah C McLoughlin, Tilo Grosser, George Cotsarelis, Garret A FitzGerald. Timed expression of Bmal1 influences aging and survival. Science Translational Medicine. Sci Transl Med 2016 Feb 3;8(324):324ra16
Anne M Curtis, Caio T Fagundes, Guangrui Yang, Eva M Palsson-McDermott, Paulina Wochal, Anne F McGettrick, Niamh H Foley, James O Early, Lihong Chen, Hanrui Zhang, Chenyi Xue, Sarah S Geiger, Karsten Hokamp, Muredach P Reilly, Andrew N Coogan, Elena Vigorito, Garret A FitzGerald, Luke AJ O’Neill. Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1. Proc Natl Acad Sci USA 2015 Jun 9;112(23):7231-7236
Lihong Chen#, Guangrui Yang#. Recent advances in circadian rhythms in cardiovascular system. Frontiers in Pharmacology 2015 Apr 1;6:71
Lihong Chen#, Zhanjun Jia, Guangrui Yang#. PPARs and metabolic syndrome. PPAR Res 2014;2014:832606
Lihong Chen, Guangrui Yang, James Monslow, Leslie Todd, David P Cormode, Jun Tang, Gregory R Grant, Jonathan H DeLonge, Soon Yew Tang, John A Lawson, Ellen Pure, Garret A FitzGerald. Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice. Proc Natl Acad Sci USA 2014;111(18):6828-6833
Lihong Chen#, Guangrui Yang#. PPARs integrate the mammalian clock and energy metabolism. PPAR Res 2014;2014:653017
Lihong Chen, Guangrui Yang, Xiufeng Xu, Gregory Grant, John A Lawson, Mohammad Bohlooly-Y, Garret A FitzGerald. Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1. Circulation 2013;127(2):233-243
Lihong Chen, Guangrui Yang, Tilo Grosser. Prostanoids and inflammatory Pain. Prostaglandins Other Lipid Mediat. 2013;104-105:58-66 [one of the 5 most highly cited papers]
Lihong Chen, Yifei Miao, Yahua Zhang, Dou Dou, Limei Liu, Xiaoyu Tian, Guangrui Yang, Dan Pu, Xiaoyan Zhang, Jihong Kang, Yuansheng Gao, Shiqiang Wang, Matthew D Breyer, Nanping Wang, Yi Zhu, Yu Huang, Richard M Breyer, Youfei Guan. Inactivation of the E-prostanoid 3 receptor attenuates the angiotensin II pressor pesponse via decreasing arterial contractility. Arterioscler Thromb Vasc Biol 2012;32(12):3024-3032
Yunfeng Zhou, Xiaomu Kong, Pan Zhao, Hang Yang, Lihong Chen, Jing Miao, Xiaoyan Zhang, Jichun Yang, Jie Ding, Youfei Guan. Peroxisome proliferator-activated receptor-α is renoprotective in doxorubicin-induced glomerular injury. Kidney International 2011;79(12):1302-1311
Miao Wang, Kaori Ihida-Stansbury, Devashish Kothapalli, Mathieu C Tamby, Zhou Yu, Lihong Chen, Gregory Grant, Yan Cheng, John A Lawson, Richard K Assoian, Peter L Jones, Garret A FitzGerald. Microsomal prostaglandin E2 synthase-1 modulates the response to vascular injury. Circulation. 2011;123(6):631-639
Fenling Fan, Aiqun Ma, Youfei Guan, Jianhua Huo, Zhi Hua, Hongyan Tian, Lihong Chen, Sen Zhu, Lihong Fan. Effect of PGE2 on DA tone by EP4 modulating Kv channels with different oxygen tension between preterm and term. Int J Cardiol. 2011;147(1):58-65
Dongjuan Zhang, Hang Yang, Xiaomu Kong, Kang Wang, Xuan Mao, Xianzhong Yan, Yuan Wang, Siqi Liu, Xiaoyan Zhang, Jing Li, Lihong Chen, Jing Wu, Mingfen Wei, Jichun Yang, Youfei Guan. Proteomics analysis reveals diabetic kidney as a ketogenic organ in type 2 diabetes. Am J Physiol Endocrinol Metab. 2011;300(2):287-295
Dongjuan Zhang, Lihong Chen, Yahua Zhang, Guangrui Yang, Dou Dou, Yuansheng Gao, Xiaoyan Zhang, Xiaomu Kong, Pan Zhao, Dan Pu, Mingfen Wei, Matthew D Breyer, Youfei Guan. Enhanced pressor response to acute Ang II infusion in mice lacking membrane-associated prostaglandin E2 synthase-1. Acta Pharmacol Sin. 2010;31(10):1284-1292
Fenling Fan, Sen Zhu, Lihong Chen, Yuliang Zou, Lihong Fan, Jihong Kang, Aiqun Ma, Youfei Guan. Role of PGE2 and its receptors in the process of the ductus arteriosus maturation and functional closure in rabbit. Clin Exp Pharmacol Physiol. 2010;37(5-6):574-580

BOOK CHAPTERS

Lihong Chen, "Nitrogen Monooxide", book chapter in Nephrology (the 3rd Edition, edited by Wang H), People's Medical Publishing House. 2008 [Articles in Chinese]
Lihong Chen, "Arachidonic acid and its derivatives", book chapter in Atherosclerosis, edited by Jiang Zh, Science Press. 2018 [Articles in Chinese]

Lu Gao

Professor and Chair, Department of Physiology, Second Military Medical University
Address: 800 Xiangyin Road, Building #1, Room 306, Shanghai, 200433, P.R. China
Phone: +86-21-81870980 (O), +86-13764554656 (C)
E-mail: roadgao@163.com

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2007: Ph.D. (Physiology), Second Military Medical University, Shanghai, China
2002: M.D., Second Military Medical University, Shanghai, China
2017-Present: Professor, Department of Physiology, Second Military Medical University, Shanghai, P.R. China
2015.01-2015.04: Senior Visiting Scholar, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX
2013.09-2014.07: Instructor, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX
2012.02-2013.08: Postdoctoral Researcher, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX
2010.07-2017.08: Associate professor, Department of Physiology, Second Military Medical University, Shanghai, P.R. China
2007.07-2010.06: Lecturer, Department of Physiology, Second Military Medical University, Shanghai, P.R. China

HONORS, PRIZES AND AWARDS
2018: Shanghai Medical Science and Technology Award
2018: Program of Shanghai Academic/Technology Research Leader
2017: Keystone Symposia Scholarship by Bill-Melinda Gates Foundation
2017: The Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
2017: “Shu Guang” project supported by Shanghai Municipal Education Commission
2017: Program of Shanghai Subject Chief Scientist
2015: Shanghai Pujiang Program
2010: The General Logistics Department of Chinese Army Award for Outstanding Young Scientist
2010: Excellent Young Scientist Award for Medical Research, Second Military Medical University (SMMU)

SELECTED PUBLICATIONS

Peng JY, Zhou YH, Zhang ZY, Wang ZM, Gao LT, Zhang X, Fang Z, Li GY, Chen HY, Yang HX, Gao L. (2018) The Detrimental Effects of Glucocorticoids Exposure during Pregnancy on Offspring's Cardiac Functions Mediated by Hypermethylation of Bone Morphogenetic Protein-4. Cell Death Dis, 9(8):834
Hu TX, Guo X, Wang G, Gao L, He P, Xia Y, Gu H, Ni X. (2017) MiR133b is involved in endogenous hydrogen sulfide suppression of sFlt-1 production in human placenta. Placenta, 52:33-40
Mendelson CR, Montalbano AP, Gao L. (2017) Fetal-to-maternal signaling in the timing of birth. J Steroid Biochem Mol Biol, 170:19-27
Gao L, Wu TW, Ni X. (2016) Gas transmitters in female reproductive system. Acta physiologica Sinica, 68(5):611-620
Gao L, Wang G, Liu WN, Kinser H, Franco HL, Mendelson CR. (2016) Reciprocal Feedback Between miR-181a and E 2/ERα in Myometrium Enhances Inflammation Leading to Labor. J Clin Endocrinol Metab, 101(10):3646–3656. (co-corresponding author)
Liu W, Xu C, You X, Olson DM, Chemtob S, Gao L, Ni X. (2016) Hydrogen Sulfide Delays LPS-Induced Preterm Birth in Mice via Anti-Inflammatory Pathways. PLoS One, 11(4):e0152838. (co-corresponding author)
Hu TX, Wang G, Guo XJ, Sun QQ, He P, Gu H, Huang Y, Gao L, Ni X. (2016) MiR 20a,-20b and -200c are involved in hydrogen sulfide stimulation of VEGF production in human placental trophoblasts. Placenta, 39:101-110. (co-corresponding author)
Xi H, An R, Li L, Wang G, Tao Y, Gao L. (2016) Myeloma bone disease: Progress in pathogenesis, Progress in Biophysics and Molecular Biology, 122(2):149-155
Gao L, Rabbitt EH, Condon JC, Renthal NE, Johnston JM, Mitsche MA, Chambon P, Xu JM, O'Malley BW and Mendelson CR. (2015) Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. Journal of Clinical Investigation, 125(7):2808-2824
Renthal NE, Williams KC, Montalbano A, Chen CC, Gao L and Mendelson CR. (2015) Molecular Regulation of Parturition: A Myometrial Perspective. Cold Spring Harb Perspect Med, 5(11):a023069
Li Y, He P, Sun Q, Liu J, Gao L, You X, Gu H, Ni X. (2013) Reduced Expression of 15-Hydroxy Prostaglandin Dehydrogenase in Chorion during Labor Is Associated with Decreased PRB and Increased PRA and GR Expression. Am J Pathol, 182(5):1585-1594
Xu B, Gao L, Wang L, Tang G, He M, Yu Y, Ni X, Sun Y. (2013) Effects of platelet-activating factor and its differential regulation by androgens and steroid hormones in prostate cancers. Br J Cancer, 109(5):1279-1286. (co-first author)
Tao Y, Gao L, Wu X, Wang H, Yang G, Zhan F, Shi J. (2013) Down-Regulation of 11beta-Hydroxysteroid Dehydrogenase Type 2 by Bortezomib Sensitizes Jurkat Leukemia T Cells against Glucocorticoid-Induced Apoptosis. PLoS One, 8:e67067. (co-first author)
Gao L, Tao Y, Hu T, Liu W, Xu C, Liu J, You X, Gu H, Ni X. (2012) Regulation of Estradiol and Progesterone Production by CRH-R1 and -R2 Is through Divergent Signaling Pathways in Cultured Human Placental Trophoblasts. Endocrinology, 153(10):4918-4928
Gao L, Lv CM, Xu C, Li Y, Cui XR, Gu H, Ni X. (2012) Differential Regulation of Glucose Transporters Mediated by CRH Receptor Type 1 and Type 2 in Human Placental Trophoblasts. Endocrinology, 153(3):1464-1471
You X, Gao L, Liu J, Xu C, Liu C, Li Y, Hui N, Gu H, Ni X. (2012) CRH Activation of Different Signaling Pathways Results in Differential Calcium Signaling in Human Pregnant Myometrium before and during Labor. J Clin Endocrinol Metab, 97(10):E1851-E1861
Xu C, Gao L, You XJ, Dai L, Li Y, Gu H, Slater DM, Olson DM, Ni X. (2011) Corticotropin-Releasing Hormone Acts on CRH-R1 and -R2 to Differentially Modulate the Expression of Large Conductance Calcium-Activated Potassium Channels in Human Pregnant Myometrium. Endocrinology, 152(11):4406-4417. (co-first author)
You XJ, Xu C, Lu JQ, Zhu XY, Gao L, Cui XR, Li Y, Gu H, Ni X. (2011) Expression of cystathionine β-synthase and cystathionine γ-lyase in human pregnant myometrium and their roles in the control of uterine contractility. PLoS One, 6:e23788
Xu C, You X, Gao L, Zhang L, Hu R, Hui N, Olson DM, Ni X. (2011) Expression of ATP-sensitive potassium channels in human pregnant myometrium. Reprod Biol Endocrinol, 9:35
Tao Y, Shi JM, Zhang YX, Gao L, Zhan FH. (2011) Expression of 11beta-hydroxysteroid dehydrogenase type 2 in lymphoblastic cells and its relationship with glucocorticoid sensitivity. Journal of experimental hematology, 19(1):109-113

Weiping Han

Address: Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), #02-02 Helios, 11 Biopolis Way, Singapore 138667
Email: wh10@cornell.edu; Tel: +65 8189 8066

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
1992-1996: Ph.D. in Physiology, Cornell University, Ithaca, NY, USA
1986-1991: B.S. in Medical Biology, Nankai University, Tianjin, China
2012-present: Deputy Director, Singapore Bioimaging Consortium, A*STAR, Singapore
2008-present: Head, Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, A*STAR, Singapore
2005-2008: Deputy Head and Group Leader, Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, A*STAR, Singapore
2003-2005: Research Assistant Professor, Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
1999-2003: HHMI Associate, Howard Hughes Medical Institute and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA
1996-1999: Research Associate, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
1992-1996: Graduate Student, Cornell University, Ithaca, NY, USA
2012-present: Research Director / Professor, Institute of Molecular and Cell Biology, A*STAR, Singapore
2017-present: Professor, Duke-NUS Medical School, Singapore
2017-present: Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS
Member, NMRC Open Fund Young Investigator Research Grant Local Review Panel (2017-2020)
Chairman, SBIC Enterprise Risk Management Committee (2014-present)
Member, NMRC Taskforce on Diabetes and Metabolic Disorders (2016-2019)
Member, Researcher Development Taskforce, A*STAR (2016-2017)
Member, Executive Committee, Singapore Bioimaging Consortium (2012-2014)
Chairman, SBIC Work Safety Committee (2006-2010)
Member, A*STAR Mouse User Committee (2009-2017)
Member, A*STAR Lead User Committee (2015-2017)
Associate Editor: Bioscience Reports (2016-present), Nutrition & Metabolism (2017-present)
Senior Editor: Journal of Endocrinology (2018-present), Journal of Molecular Endocrinology (2018-present)
Editorial Board: Medicine in Drug Discovery (2019-present), Diabetes and Metabolism Journal (2014-present), Experimental & Molecular Medicine (2013-2016), Bioscience Reports (2012-present), Journal of Innovative Optical Health Sciences (2008-present), Journal of Molecular Cell Biology (2017-2021)
Editorial Advisory Board: Biochemical Journal (2011-present)
Review Editor: Frontiers in Systems Physiology (2010-present)
Guest Associate Editor for Frontier Research Topic: Glucagon secretion and signaling in the development of diabetes (2011-2013)
Invited reviewers for PNAS, JCB, JCI, JBC, BJ, Endocrinology, Diabetologia, JCEM, PLoS Biology, Nature Metabolism, etc
Invited grant reviewers for NMRC (Singapore), RGC (Hong Kong), American Diabetes Association (2005-now)
Chinese American Diabetes Association (Lifetime member since 2006)
The Asia-Pacific Diabetes and Obesity Study Group (member of the Organizing Committee since 2007)
Asian Diabetes and Obesity Network (member of the Executive Committee since 2012)
The Biochemical Society (2016-present)
The Endocrine Society (2009-2011)
The American Society for Cell Biology (2011-2013)
Society of Neuroscience (2015-2017)

SELECTED PUBLICATIONS

Ding Z, Ericksen RE, Escande-Beillard N, Lee QY, Loh A, Denil S, Seckel M, Haegebarth A, Ho T, Chow P, Toh HC, Reversade B, Gruenewald, Han W*. Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis. J Hepatol 72(4):725-735, 2020
Li HY, Liu YX, Harvey L, Shafaeizadeh S, van der Beek EM, Han W. A mouse model of gestation-specific transient hyperglycemia for translational studies. J Endocrinol 244(3):501-510, 2020
Singh JP, Qian K, Lee JS, Zhou J, Han X Zhang B, Ong Q, Ni W, Jiang M, Ruan HB, Li MD, Zhang K, Ding Z, Lee P, Singh K, Wu J, Herzog RI, Kaech S, Wendel HG, Yates JR 3rd, Han W, Sherwin RS, Nie Y, Yang X. O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth. Oncogene 39(3):560-573, 2020
Mcilroy GD, Mitchell SE, Han W, Delibegovic M, Rochford JJ. Ablation of Bscl2/Seipin in hepatocytes does not cause metabolic dysfunction in congential generalized lipodystrophy. Dis Model Mech 13(1):dmm042655, 2020
Bai B, Yang W, Fu Y, Lee HFW, Tay WT, Yang K, Luo C, Gunaratne J, Lee P, Zile MR, Xu A, Chin CWL, Lam CSP, Han W*, Wang Y*. Seipin knockout mice develop heart failure with preserved ejection fraction. JACC Basic Transl Sci 4(8):924-937, 2019
Sriram S, Yuan C, Chakraborty S, Tay W, Park M, Shabbir A, Toh S-A, Han W, Sugii S. Oxidative stress mediates depot-specific functional differences of human adipose-derived stem cells. Stem Cell Res Ther 10(1):141, 2019
Ericksen RE, Han W. Malignant manipulaTORs of metabolism: suppressing BCAA catabolism to enhance mTORC1 activity. Mol Cell Oncol 6(3):1585171, 2019
Yuan C, Chakraborty S, Chitta KK, Subramanian S, Lim TE, Han W, Bhanu Prakash KN, Sugii S. Fast adipogenesis tracking system (FATS) – a robust, high-throughput, automation-ready adipogenesis quantification technique. Stem Cell Res Ther 10(1):38, 2019
Ericksen RE, Lim SL, McDonnell E, Shuen WH, Vadiveloo M, White PJ, Ding Z, Kwok R, Lee P, Radda GK, Toh HC, Hirschey MD, Han W. Loss of BCAA catabolism during carcinogenesis enhances mTORC1 activity and promotes tumor development and progression. Cell Metabolism 29(5):1151-1165, 2019
Chong YC, Lim TE, Fu Y, Shin EM, Tergaonkar V, Han W. Indian Hedgehog links obesity to development of hepatocellular carcinoma. Oncogene 38(12):2206-2222, 2019
Mcilroy GD, Mitchell SE, Han W, Delibegovic M, Rochford JJ. Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet. Scientific Reports 8(1):17863, 2018
Vacz G, Major B, Gaai D, Petrik L, Horvathy DB, Han W, Holczer T, Simon M, Muir JM, Hornyak I, Lacza Z. Hyperacute serum has markedly better regernative efficacy than platelet-rich plasma in a human bone oxygen-glucose deprivation model. Regenerative Medicine 13(5):531-543, 2018
Luo XS, Huang J, Li Q, Mohammad H, Lee C-Y, Krishna K, Kok AM, Tan YL, Lim JY, Li H, Yeow LY, Sun J, He M, Grandjean J, Sajikumar S, Han W, Fu Y. Feeding regulation by tuberal nucleus somatostatin neurons. Science 361(6397):76-81, 2018
Chan XHD, Balasundaram G, Attia ABE, Goggi JL, Ramasamy B, Han W, Olivo M, Sugii S. Multimodal imaging approach to monitor browning of adipose tissue in vivo. Journal of Lipid Research 59(6):1071-1078, 2018
Huang C, Walker EM, Dadi PK, Hu R, Xu Y, Zhang W, Sanavia T, Mun J, Liu J, Nair GG, Tan HYA, Wang S, Magnuson MA, Stoeckert CJ, Hebrok M, Gannon M, Han W, Stein R, Jacobson DA, Gu G. Synaptotagmin-4 regulates pancreatic b-cell maturation by modulating the Ca2+ sensitivity of insulin secretion vesicles. Development Cell 45(3):347-361, 2018
Mciloroy GD, Suchacki K, Roelofs AJ, Yang W, Fu Y, Bai B, Wallace RJ, De Bari C, Cawthorn WP, Han W, Delibegovic M, Rochford J. Adipose specific disruption of seipin causes early-onset generalized lipodystrophy and altered fuel utilization without severe metabolic disease. Molecular Metabolism 10:55-65, 2018
Rewcastle G, Kolekar S, Buchanan C, Gamage S, Giddens A, Tsang K, Kendall J, Singh R, Lee WJ, Smith G, Han W, Matthews D, Denny W, Shepherd P, Jamieson S. Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Ka, in comparison to established pan PI3K inhibitors. Oncotarget 8(29):47725-47740, 2017
Ng R, Hussain NA, Chang CW, Li HY, Han W, Stunkel W, Xu F. miRNA-32 Trans-activates Subcutaneous White Fat Browning by Promoting FGF21 Expression in Brown Adipose Tissue. Cell Reports 19(6):1229-1246, 2017
Sim CK, Kim SY, Brunmeir R, Zhang Q, Li H, Dharmasegaran D, Leong C, Lim YY, Han W, Xu F. Regulation of white and brown adipocyte differentiation by RhoGAP DLC1. PLoS One 12(3):e0174761, 2017
Zeng W, Zhang C, Cheng H, Wu YL, Liu J, Chen Z, Huang JG, Ericksen RE, Chen L, Zhang H, Wong AS, Zhang XK, Han W, Zeng JZ. Targeting to the non-genomic activity of retinoic acid receptor-gamma by acacetin in hepatocellular carcinoma. Scientific Reports 7(1):348, 2017
Julien SG, Kim SY, Brunmeir R, Sinnakannu JR, Ge X, Li H, Ma W, Yaligar J, Kn BP, Velan SS, Roder PV, Zhang Q, Sim CK, Wu J, Garcia-Miralles M, Pouladi MA, Xie W, McFarlane C, Han W, Xu F. Narciclasine attenuates diet-induced obesity by promoting oxidative metabolism in skeletal muscle. PLoS Biology 15(2):e1002597, 2017
Ulyanova A, To XV, Asad AB, Han W, Chuang KH. MEMRI detects neuronal activity and connectivity in hypothalamic neural circuit responding to leptin. Neuroimage 147:904-915, 2017
Ng Y, Tan S, Chia SY, Sun L, Hong W, Han W. HoxC10 suppresses browning of white adipose tissue. Exp Mol Med 49(2):e292, 2017
Mao L, Nie B, Nie T, Hui X, Gao X, Lin X, Liu X, Xu Y, Tang X, Yuan R, Li K, Li P, Ding K, Wang Y, Xu A, Fei J, Han W, Liu P, Madsen L, Kristiansen K, Zhou Z, Ding S, Wu D. Visualization and quantification of browning using a UCP1-2A-Luciferase knock-in mouse model. Diabetes 66(2):407-417, 2017
Sorrenson B, Cognard E, Lee KL, Dissanayake WC, Fu Y, Han W, Hughes WE, Shepherd PR. A critical role for β-catenin in modulating levels of insulin secretion from β-cells by regulating actin cytoskeleton and insulin vesicle localization. J Biol Chem 291(50):25888-25900, 2016
Liu T, Li H, Hong W, Han W. BIG3 is localized in lysosomes and regulates inhibitory synaptic transmission in hippocampal neurons. J Neurochem 139(5):748-756, 2016
Li H, Kek HC, Lim J, Gelling RW, Han W. Green tea (‐)‐epigallocatechin‐3‐gallate counteracts daytime overeating induced by high‐fat diet in mice. Mol Nutr Food Res 60(12):2565-2575, 2016
Nie T, Hui X, Mao L, Nie B, Li K, Sun W, Gao X, Tang X, Xu Y, Jiang B, Tu Z, Li P, Ding K, Han W, Zhang S, Xu A, Ding S, Liu P, Patterson A, Cooper G, Wu D. Harmine induces adipocyte thermogenesis through RAC1-MEK-ERK-CHD4 axis. Sci Rep 6:36382, 2016
Chen N, Sugihara H, Kim J, Fu Z, Barak B, Sur M, Feng G*, Han W*. Direct modulation of GFAP-expressing glia in the Arcuate nucleus bi-directionally regulates feeding. elife 5:e18716, 2016 (*co-corresponding authors)
Lim YC, Chia SY, Jin S, Han W, Ding C, Sun L. Dynamic DNA methylation landscape defines brown and white cell specificity during adipogenesis. Mol Metab 5(10):1033-1041, 2016
Kim S-Y, Sim CK, Zhang Q, Tang H, Brunmeir R, Pan H, Karnani N, Han W, Zhang K, Xu F. An alternative strategy for pan-acetyl-lysine antibody generation. PLoS One 11(9):e0162528, 2016
Bai B, Man AW, Yang K, Guo Y, Xu C, Tse HF, Han W, Bloksgaard M, De Mey JG, Vanhoutte PM, Xu A, Wang Y. Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1. Oncotarget 7(26):39065-39081, 2016
Kim S-Y, Sim KC, Tang H, Han W, Zhang K, Xu F. Acetylome study in mouse adipocytes identifies targets of SIRT1 deacetylation in chromatin organization and RNA processing. Arch Biochem Biophys 598:1-10, 2016
Takeda K, Sriram S, Chan DXH, Ong WK, Yeo CR, Tan B, Lee SA, Kong KV, Hoon S, Jiang H, Yuen JJ, Perumal J, Agrawal M, Vaz C, So J, Shabbir A, Blaner WS, Olivo M, Han W, Tanavde V, Toh SA, Sugii S. Retinoic acid mediates visceral-specific adipogenic defects of human adipose-derived stem cells. Diabetes 65(5):1164-1178, 2016
Wang C, Wang Y, Hu M, Han W, Zhang CX, Zhou Z. Synaptotagmin-11 inhibits clathrin-mediated and bulk endocytosis. EMBO Reports 17(1):47-63, 2016
Yuan Q, Yang F, Xiao Y, Tan S, Husain N, Ren M, Hu Z, Martinowich K, Ng JS, Kim PJ, Han W, Nagata KI, Weinberger DR, Je HS. Regulation of Brian-Derived Neurotrophic Factor exocytosis and Gamma-Aminobutyric Acidergic interneuron synapse by the schizophrenia susceptibility gene dysbindin-1. Biol Psychiatry 80(4):312-322, 2016
Huo J, Ma Y, Liu JJ, Ho YS, Liu S, Soh LY, Chen S, Xu S, Han W, Hong A, Lim SC, Lam KP. Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis. Cell Death Dis 7:e2091, 2016
Kim ES, Samanta A, Cheng HS, Ding Z, Han W, Toschi L, Chang YT. Effect of oncogene activating mutations and kinase inhibitors on amino acid metabolism of human isogenic breast cancer cells. Mol Biosyst 11(12):3378-3386, 2015
Kim S-Y, Sim CK, Tang H, Han W, Zhang K, Xu F. Acetylome analysis identifies SIRT1 targets in mRNA-processing and chromatin-remodeling in mouse liver. PLoS ONE 10(10):e0140619, 2015
Lim CY, Hong W, Han W. Adiponectin is stored and released through a regulated mechanism in adipocytes. Biochem J 471(3):381-389, 2015
Wu B, Wei S, Petersen N, Ali Y, Wang X, Rorsman P, Hong W, Südhof TC*, Han W*. Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells. Proc Natl Acad Sci U S A 112(32):9996-10001, 2015 (*co-corresponding authors)
Liu Y*, Li H*, Sugiura Y*, Han W*, Gallardo G, Khvotchev M, Zhang Y, Kavalali ET, Südhof TC, Lin W. Ubiquitin-synaptobrevin fusion protein causes degeneration of presynaptic motor terminals in mice. J Neurosci 35(33):11514-11531, 2015 (*co-first author)
Qiu B, Shi X, Zhou Q, Chen H, Lim J, Han W*, Tergaonkar V*. Hypothalamic NUCKS regulates peripheral glucose homeostasis. Biochem J 469(3):391-398, 2015 (*co-corresponding authors)
Kim S-Y, Zhang Q, Brunmeir R, Han W, Xu F. SIRT1 interacts with and deacetylates ATP6V1B2 in mature adipocytes. PLoS ONE 10(7):e0133448, 2015
Kee AJ, Yang L, Lucas CA, Greenberg MJ, Martel N, Leong GM, Hughes WE, Cooney GJ, James DE, Ostap EM, Han W, Gunning PW, Hardeman EC. An actin filament population defined by the tropomyosin Tpm3.1 regulates glucose uptake. Traffic 16(7):691-711, 2015
Nie T, Hui X, Gao X, Nie B, Mao L, Tang X, Yuan R, Li K, Li P, Xu A, Liu P, Ding S, Han W, Cooper G, Wu D. Direct conversion of non-adipogenic fibroblasts into adipocytes by a defined hormone mixture. Biochem J 467(3):487-494, 2015
Kim JI, Huh JY, Sohn JH, Choe SS, Lee YS, Lim CY, Jo A, Park SB, Han W, Kim JB. Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation. Molecular and Cell Biology 35(10):1686-1699, 2015
Li H, Liu T, Lim J, Gounko NV, Hong W, Han W. Increased biogenesis of glucagon-containing secretory granules and glucagon secretion in BIG3-knockout mice. Mol Metab 4(3):246-252, 2015
Xu P, Wu J, Brunmeir R, Kim S, Zhang Q, Ding C, Han W, Xie W, Xu F. TELP: a sensitive and versatile library construction method for next-generation sequencing. Nucleic Acids Res 43(6):e35, 2015
Ma W, Fuentes G, Verma C, Radda GK, Han W. FoxO1 negatively regulates leptin-induced POMC transcription through direct interaction with STAT3. Biochem J 466(2):291-298, 2015
Lim CY, Bi X, Wu D, Kim JB, Gunning PW, Hong W, Han W. Tropomodulin 3 is a novel Akt2 effector regulating GLUT4 exocytosis. Nat Commun 6:5951, 2015
Lim CY, Han W. Tropomodulin 3 as the link between insulin-activated AKT2 and cortical actin remodeling in preparation of GLUT4 exocytosis. Bioarchitecture 4(6):210-214, 2014
Ramlee MK, Zhang Q, Idris M, Peng X, Sim CK, Han W, Xu F. Histone H3 K27 acetylation marks a potent enhancer for the adipogenic master regulator gene Pparg2. Cell Cycle 13(21):3414-3422, 2014
Yang W, Thein S, Lim C-Y, Ericksen RE, Sugii S, Xu F, Robinson RC, Kim JB, Han W. Arp2/3 complex regulates adipogenesis by controlling cortical actin remodeling. Biochem J 464(2):179-192, 2014
Liu T, Li H, Gounko NV, Zhou Z, Xu A, Hong W, Han W. Detection of insulin granule exocytosis by an electrophysiology method with high temporal resolution reveals enlarged insulin granule pool in BIG3-knockout mice. Am J Physiol Endocrinol Metab 307(7):E611-618, 2014
Hornyak I, Madacsi E, Kalugyer P, Vacz G, Horvathy DB, Szendroi M, Han W, Lacza Z. Increasing release time of antibiotics from bone allografts through a novel biodegradable coating. Biomed Res Int 2014:459867. 2014
Smith GC, Zhang ZY, Mulvey T, Lach S, Xiu P, Petersen N, Han W, Phillips A, Wang MW, Shepherd PR. Clozapine directly increases insulin and glucagon secretion from islets: Implications for impairment of glucose tolerance. Schizophr Res 157(1-3):128-133, 2014
Qiu B, Shi X, Wong ET, Lim J, Bezzi M, Low D, Zhou Q, Akincilar SC, Lakshmanan M, Swa HL, Tham JM, Gunaratne J, Cheng KK, Hong W, Lam KS, Ikawa M, Guccione E, Xu A, Han W*, Tergaonkar V*. NUCKS is a positive transcriptional regulator of insulin signaling. Cell Reports 7(6):1876-1886, 2014 (*co-corresponding authors)
Li H, Wei S, Cheng K, Gounko NV, Ericksen RE, Xu A, Hong W*, Han W*. BIG3 inhibits insulin granule biogenesis and insulin secretion. The EMBO Reports 15(6):714-722, 2014 (*co-corresponding authors)
Ericksen RE, Rose S, Westphalen CB, Shibata W, Muthupalani S, Tailor Y, Han W, Fox JG, Ferrante AW, Wang TC. Obesity accelerates Helicobacter felis-induced gastric carcinogenesis by enhancing immature myeloid cell trafficking and TH17 response. GUT 63(3):385-394, 2014
Wang Y, Ali Y, Lim CY, Hong W, Pang Z*, Han W*. Insulin-stimulated leptin secretion requires calcium and PI3K-Akt activation. Biochem J 458(3):491-498, 2014 (*co-corresponding authors)
Ong WK, Tan CS, Chan KL, Goesantoso GG, Chan XHD, Chan E, Yin J, Yeo CR, Khoo CM, So J, Shabbir A, Toh S-A, Han W, Sugii S. Identification of specific surface markers of adipose-derived stem cells from subcutaneous and visceral fat depots. Stem Cell Reports 2(2):171-179, 2014
Wei S, Soh S, Qiu W, Yang W, Guo J, Ong W-Y, Pang Z*, Han W*. Seipin with motor neuropathy-associated mutations impairs neurotransmission in cortical neurons. J Neurochem 129(2):328-338, 2014 (*co-corresponding authors)
Wang X, Lacza Z, Sun YE, Han W. Leptin resistance and obesity in mice with deletion of MeCP2 in hypothalamic POMC neurons. Diabetologia 57(1):236-245, 2014
Yang W, Thein S, Wang X, Bi X, Ericksen RE, Xu F, Han W. BSCL2/Seipin regulates adipogenesis through actin cytoskeleton remodeling. Hum Mol Genet 23(2):502-513, 2014
Xie S, Sinha RA, Singh BK, Li GD, Han W, Yen PM. Resveratrol induces insulin gene expression in mouse pancreatic α-cells. Cell Biosci 3(1):47, 2013
Liu Z, Lim CY, Su M, Soh SLY, Shui G, Wenk MR, Grove KL, Radda GK, Han W*, Xiao X*. Neonatal overnutrition in the mice exacerbates high fat diet induced metabolic perturbations. J Endocrinol 219(2):131-143, 2013 (* co-corresponding authors)
Kostromina E, Wang X, Han W. Altered islet morphology but normal islet secretory function in vitro in a mouse model with microvascular alterations in the pancreas. PLoS ONE 8(7):e71277, 2013
Smith GC, Ong WK, Costa JL, Watson M, Cornish J, Grey A, Gamble GD, Dickinson M, Leung S, Rewcastle GW, Han W, Shepherd PR. Extended treatment with selective phosphoinositide 3-kinase and mTOR inhibitors has effects on metabolism, growth, behavior and bone strength. FEBS J 280(21):5337-5349, 2013
Kang N-Y, Lee S-C, Park S-J, Ha H-H, Yun S-W, Kostromina E, Gustavsson N, Ali Y, Chandran Y, Chun H-S, Bae MA, Ahn JH, Han W, Radda GK, Chang Y-T. Visualization and isolation of Langerhans islets by a fluorescent probe PiY. Angewandte Chemie 52(33):8557-8560, 2013
Yang W, Thein S, Guo X, Xu F, Venkatesh B, Sugii S, Radda GK, Han W. Seipin differentially regulates lipogenesis through a conserved core sequence and an evolutionarily acquired C-terminus. Biochem J 452(1):37-44, 2013
Guo J, Qiu W, Soh S, Wei S, Radda GK, Ong W-Y, Pang Z*, Han W*. Motor neuron degeneration in a mouse model of Seipinopathy. Cell Death Dis 4, e535, 2013 (*co-corresponding authors)
Qiu W, Wee K, Takeda K, Lim X, Sugii S, Radda GK, Han W. Suppression of adipogenesis by pathogenic Seipin mutant is associated with inflammatory response. PLoS ONE 8(3):e57874, 2013
Shi X, Wang X, Su M, Li Q, Chew E, Wong ET, Lacza Z, Radda GK, Tergaonkar V, Han W. NF-kB suppresses food intake and energy expenditure by directly activating POMC promoter. Diabetologia 56(4):925-936, 2013
Burchfield JG, Lu J, Fazakerley DJ, Tan SX, Ng Y, Mele K, Buckley MJ, Han W, Hughes WE, James DE. Novel systems for dynamically assessing insulin action in live cells reveals heterogeneity in the insulin response. Traffic 14(3):259-273, 2013
Wei S, Soh S, Qiu W, Yang W, Seah C, Guo J, Ong W-Y, Pang Z, Han W. Seipin regulates excitatory synaptic transmission in cortical neurons. J Neurochem 124(4):478-489, 2013
Yang W, Guo X, Thein S, Xu F, Sugii S, Baas PW, Radda GK, Han W. Regulation of adipogenesis by cytoskeleton remodeling is facilitated by acetyltransferase MEC-17-dependent acetylation of a-tubulin. Biochem J 449(3):605-612, 2013
Lee P, Leong W, Tan T, Lim M, Han W, Radda GK. In vivo hyperpolarized 13C-labeled magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin-resistant mouse model. Hepatology 57(2):515-524, 2013
Bardy J, Chen A, Lim YM, Wu SM, Wei S, Han W, Chan KK, Reuveny S, Oh S. Microcarrier suspension cultures for high density expansion and differentiation of human pluripotent stem cells to neural progenitor cells. Tissue Eng Part C Methods 19(2):166-180, 2013
Le Guezennec X, Brichkina A, Huang Y-F, Kostromina E, Han W, Bulavin DV. Wip1-dependent regulation of autophagy, obesity, and atherosclerosis. Cell Metab 16:68-80, 2012
Pola A, Sadananthan SA, Yaligar J, Nagarajan V, Han W, Kuchel PW, Velan SS. Skeletal muscle lipid metabolism studied by advanced magnetic resonance spectroscopy. Prog Nucl Magn Reson Spectrosc 65:66-76, 2012
Smith GC, Ong WK, Rewcastle G, Kendall JD, Han W, Shepherd PR. Effects of acutely inhibiting phosphatidylinositol 3-kinase isoforms and mTOR on regulation of glucose metabolism. Biochem J 442(1):161-169, 2012
Lou PH, Gustavsson N, Wang Y, Radda GK, Han W. Increased lipolysis and energy expenditure in a mouse model with severely impaired glucagon secretion. PLoS ONE 6(10):e26671, 2011
Xiong W, Liu T, Wang Y, Chen X, Sun L, Guo N, Zheng H, Zheng L, Ruat M, Han W, Zhang CX, Zhou Z*. An inhibitory effect of extracellular Ca2+ on Ca2+-dependent exocytosis. PLoS ONE 6(10):e24573, 2011
Liu T, Sun L, Xiong Y, Shang S, Guo N, Teng S, Wang Y, Liu B, Wang C, Wang L, Zheng L, Zhang CX*, Han W*, Zhou Z*. Calcium triggers exocytosis from two types of organelles in a single astrocyte. J Neurosci 31(29):10593-10601, 2011 (*co-corresponding authors)
Gustavsson N, Wang Y, Kang Y, Seah T, Radda GK, Han W. Synaptotagmin-7 as a positive regulator of glucose-induced glucagon-like peptide-1 secretion. Diabetologia 54(7):1824-1830, 2011
Gustavsson N, Seah T, Lao Y, Radda GK, Südhof TC, Han W. Delayed onset of hyperglycemia in a mouse model with impaired glucagon secretion demonstrates that dysregulated glucagon secretion promotes hyperglycemia and type 2 diabetes. Diabetologia 54(2):415-423, 2011
Gustavsson N, Wang X, Seah T, Wang Y, Xu J, Radda GK, Südhof TC, Han W. Neuronal Calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion. PLoS ONE 5(11):e15414, 2010
Wei S, Xu Y, Shi H, Wong SH, Han W, Talbot K, Hong W, Ong WY. EHD1 is a synaptic protein that modulates exocytosis through binding to snapin. Mol Cell Neurosci 45(4):418-429, 2010
Lou PH, Yang G, Huang L, Cui Y, Pourbahrami T, Radda GK, Li C, Han W. Reduced body weight and increased energy expenditure in transgenic mice over-expressing the soluble leptin receptor. PLoS One 5(7):e11669, 2010
Han W, Chuang K-H, Chang YT, Olivo M, Velan SS, Townsend D, Bhakoo K, Radda GK. Imaging metabolic syndrome. EMBO Mol Med 2(6):196-210, 2010
Yang L, Gan Z, Zhao L, He Z, Xu J, Li W, Gao X, Wang X, Han W, Chen L, Xu T, Liu Y. Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis. FASEB J 24(10): 3720-3732, 2010
Kostromina E, Gustavsson N, Wang X, Lim CY, Radda GK, Li C, Han W. Glucose intolerance and impaired insulin secretion in pancreas-specific STAT3 KO mice are associated with reduced microvasculature around pancreatic islets. Endocrinology 151(5):2050-2059, 2010

BOOK CHAPTERS

Ong Q, Han W, Yang X. O-GlcNAc as an integrator of signaling pathways. Frontiers Endocrinology (Lausanne) 9:599, October 16, 2018
Peng X, Zhang Q, Han W, Xu F. Epigenomic control of thermogenic adipocyte differentiation and function. International Journal of Molecular Sciences 19(6):E1793, June 2018
Roeder PV, Wong X, Hong W, Han W. Molecular regulation of insulin granule biogenesis and exocytosis. The Biochemical Journal 473(18):2737-2756, September 15, 2016
Roeder PV, Wu B, Liu Y, Han W. Pancreatic regulation of glucose homeostasis. Experimental & Molecular Medicine 48:e219, 2016
Qiu B, Han W*, Tergaonkar V*. NUCKS: a potential biomarker and therapeutic target for cancer and metabolic diseases. Clinical Science 128(10):715-721, 2015. (*co-corresponding authors)
Wee K, Yang W, Sugii S, Han W. Lipodystrophy, Seipin and molecular mechanisms. Bioscience Reports 34(5):e00141, 2014
Lu J, Bhakoo K, Chuang K-H, Radda GK, Kuchel PW, Han W. Imaging in metabolic medicine (book chapter in Imaging in Cellular and Tissue Engineering), 191-211, 2013
Han W. Dual functions of adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) in insulin signaling and insulin secretion (commentary). Proceedings of the National Academy of Sciences of the United States of America 109(23):8795-8796, 2012
Pang ZP, Han W. Regulation of synaptic functions in central nervous system by endocrine hormones and the maintenance of energy homeostasis. Bioscience Reports 32(5):423-432,2012
Gustavsson N, Wu B, Han W. Calcium sensing in exocytosis (book chapter in Calcium Signaling). Advances in Experimental Medicine and Biology 740:731-757, 2012
Han W, Li C. Linking type 2 diabetes and Alzheimer's disease (commentary). Proceedings of the National Academy of Sciences of the United States of America 107(15):6557-6558, 2010

Wei Kong

Chair, Department of Physiology and Pathophysiology, Peking University Health Science Center
Tel: 86(10) 8280-5594
Email: kongw@bjmu.edu.cn

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
1995.07: M.D. in Medicine, Department of Internal Medicine, Tongji Medical College of Huazhong University of Science & Technology, CHINA
2000.07: Ph.D in Pathophysiology, Department of Pathophysiology, Tongji Medical College of Huazhong University of Science & Technology CHINA
2001-2003: Research Associate, Department of Pharmaceutics, University of Washington, Seattle, USA
2003-2005: Postdoctoral Research Fellow, Department of Orthopaedic Surgery and Department of Cell Biology, New York University School of Medicine, New York, NY, 10003, USA
2005.12-2010.07: Associate professor of Physiology, Department of Physiology and Pathophysiology, Peking (Beijing) University Health Science Center, Beijing 100191
2010.08-present: Professor of Physiology, Department of Physiology and Pathophysiology, Peking (Beijing) University Health Science Center, Beijing 100191
2016.12-present: Chair, Department of Physiology and Pathophysiology，Peking University Health Science Center

HONORS, PRIZES AND AWARDS
The Youth Science and Technology Award China
Distinguished Young Scholars from National Science Fund, P.R.China 2012
New Century Excellent Talents in University, Ministry of Education, P.R.China 2007
Distinguished Fok Ying Dong Young Scholar Award, P.R.China 2007
New Star of Technology, Beijing, P.R.China, 2008

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS
Editorial Boards
Matrix Biology
Cardiovasc Res
J Mol Cell Cardiol
Cellular Signalling
Cardiovascular Drugs and Therapy
Current Vascular Pharmacology
Current Angiogenesis
Frontiers in Physiology
2016-2017 President, Chinese Society of Matrix Biology
2016-present Committee member, International Society of Matrix Biology
2015-present Committee member, Chinese Association of Physiological Science

SELECTED PUBLICATIONS (*corresponding author)

She S, Wu X, Zheng D, Pei X, Ma J, Sun Y, Zhou J, Nong L, Guo C, Lv P, Song Q, Zheng C, Liang W, Huang S, Li Q, Liu Z, Song Z, Li Y, Zhang Y, Kong W, You H, Xi J, Wang Y. PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target. J Hepatol. 2020 Mar;72(3):506-518
Cong X, Kong W*. Endothelial tight junctions and their regulatory signaling pathways in vascular homeostasis and disease. Cell Signal. 2020 Feb;66:109485 [Review]
Qi L, Chi X, Zhang X, Feng X, Chu W, Zhang S, Wu J, Song Y, Zhang Y, Kong W, Yu Y, Zhang H. Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy. Cell Death Dis. 2019 Nov 26;10(12):890
Huang SM, Yang F, Cai BY, He QT, Liu Q, Qu CX, Han MJ, Kong W, Jia YL, Li F, Yu X, Sun JP, Wang J. Genetically Encoded Fluorescent Amino Acid for Monitoring Protein Interactions through FRET. Anal Chem. 2019 Dec 3;91(23):14936-14942
Zhou B, Li W, Zhao G, Yu B, Ma B, Liu Z, Xie N, Fu Y, Gong Z, Dai R, Zhang X, Kong W. Rapamycin prevents thoracic aortic aneurysm and dissection in mice. J Vasc Surg. 2019 Mar;69(3):921-932
Liu Y, Liu Z, Tang H, Shen Y, Gong Z, Xie N, Zhang X, Wang W, Kong W, Zhou Y, Fu Y. The N6-methyladenosine (m6A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNA. Am J Physiol Cell Physiol. 2019 Oct 1;317(4):C762-C775
Liu M, Li L, Zhu J, He C, Xu Q, Sun A, Kong W, Li W, Zhang X. Biochem Biophys Res Commun. 2019 May 7;512(3):498-504
Liu X, Li J, Liao J, Wang H, Huang X, Dong Z, Shen Q, Zhang L, Wang Y, Kong W, Liu G, Huang W. Gpihbp1 deficiency accelerates atherosclerosis and plaque instability in diabetic Ldlr-/- mice. Atherosclerosis. 2019 Mar;282:100-109
Liu M, Li L, Zhu J, He C, Xu Q, Sun A, Kong W, Li W, Zhang X. Rapamycin attenuates a murine model of thoracic aortic aneurysm by downregulating the miR-126-3p mediated activation of MAPK/ERK signalling pathway. Biochem Biophys Res Commun. 2019 May 7;512(3):498-504
Zhang D, Wang X, Chen S, Chen S, Yu W, Liu X, Yang G, Tao Y, Tang X, Bu D, Zhang H, Kong W, Tang C, Huang Y, Du J, Jin H. Endogenous hydrogen sulfide sulfhydrates IKKβ at cysteine 179 to control pulmonary artery endothelial cell inflammation. Clin Sci (Lond). 2019 Oct 30;133(20):2045-2059
Sun L, Pang Y, Wang X, Wu Q, Liu H, Liu B, Liu G, Ye M, Kong W, Jiang C. Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters. Acta Pharm Sin B. 2019 Jul;9(4):702-710
Lian G, Li X, Zhang L, Zhang Y, Sun L, Zhang X, Liu H, Pang Y, Kong W, Zhang T, Wang X, Jiang C. Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway. EBioMedicine. 2019 Nov;49:291-304
Shao F, Miao Y, Zhang Y, Han L, Ma X, Deng J, Jiang C, Kong W, Xu Q, Feng J, Wang X. B cell-derived anti-beta 2 glycoprotein I antibody contributes to hyperhomocysteinemia-aggravated abdominal aortic aneurysm. Cardiovasc Res. 2019 Nov 29;cvz288
Zhang X, Zhang Y, Wang P, Zhang SY, Dong Y, Zeng G, Yan Y, Sun L, Wu Q, Liu H, Liu B, Kong W, Wang X, Jiang C. Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism. Cell Metab. 2019 Nov 5;30(5):937-951
Tang RZ, Zhu JJ, Yang FF, Zhang YP, Xie SA, Liu YF, Yao WJ, Pang W, Han LL, Kong W, Wang YX, Zhang T, Zhou J. DNA methyltransferase 1 and Krüppel-like factor 4 axis regulates macrophage inflammation and atherosclerosis. J Mol Cell Cardiol. 2019 Jan 16;128:11-24
Wang Y, Chen D, Zhang Y, Wang P, Zheng C, Zhang S, Yu B, Zhang L, Zhao G, Ma B, Cai Z, Xie N, Huang S, Liu Z, Mo X, Guan Y, Wang X, Fu Y, Ma D, Wang Y, Kong W*. A Novel Adipokine, FAM19A5, Inhibits Postinjury Neointima Formation through Sphingosine-1-Phosphate Receptor 2. Circulation. 2018 Jul 3;138(1):48-63 (Editorial comment)
Zhang D, Wang X, Tian X, Zhang L, Yang G, Tao Y, Liang C, Li K, Yu X, Tang X, Tang C, Zhou J, Kong W, Du J, Huang Y, Jin H. The Increased Endogenous Sulfur Dioxide Acts as a Compensatory Mechanism for the Downregulated Endogenous Hydrogen Sulfide Pathway in the Endothelial Cell Inflammation. Front Immunol. 2018 Apr 30;9:882
Wang S, Liu Y, Zhao G, He L, Fu Y, Yu C, Wang Z, Zhao T, Cao F, Gao Y, Kong W*, Zheng J*. Postnatal deficiency of ADAMTS1 ameliorates thoracic aortic aneurysm and dissection in mice. Exp Physiol. 2018 Dec;103(12):1717-1731
Ma B, Yao F, Xie N, Mao C, Liu F, Gong Z, Zhao G, Liu Z, Cai Z, Yu F, Dai R, Chen Z, Wang L, Xu Q, Kong W*, Fu Y*. Cartilage oligomeric matrix protein is a novel notch ligand driving embryonic stem cell differentiation towards the smooth muscle lineage. J Mol Cell Cardiol. 2018 Aug;121:69-80
Yao F, Yu P, Li Y, Yuan X, Li Z, Zhang T, Liu F, Wang Y, Wang Y, Li D, Ma B, Shu C, Kong W, Zhou B, Wang L. Histone Variant H2A.Z is Required for the Maintenance of Smooth Muscle Cell Identity as Revealed by Single-Cell Transcriptomics. Circulation. 2018 Nov 13;138(20):2274-2288
Jia Y, Wang M, Mao C, Yu F, Wang Y, Xiao R, Jiang C, Zheng L, Xu Q, Zheng M, Fu Y, Hu Q, Kong W*. COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity. Cell Death Dis. 2018 Jun 4;9(6):676
He L, Fu Y, Deng J, Shen Y, Wang Y, Yu F, Xie N, Chen Z, Hong T, Peng X, Li Q, Zhou J, Han J, Wang Y, Xi J, Kong W*. Deficiency of FAM3D (Family With Sequence Similarity 3, Member D), A Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm Development. Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1616-1631
Liu XJ, Wu XY, Wang H, Wang SX, Kong W, Zhang L, Liu G, Huang W. Renal injury in Seipin-deficient lipodystrophic mice and its reversal by adipose tissue transplantation or leptin administration alone: adipose tissue-kidney crosstalk. FASEB J. 2018 Oct;32(10):5550-5562
Li L, Zhao Q, Kong W*. Extracellular matrix remodeling and cardiac fibrosis. Matrix Biol. 2018 Aug;68-69:490-506
Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun J, Kong W*. Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury. Nat Commun. 2018 Jan 2;9(1):11
Gao Y, Wang Z, Zhang Y, Liu Y, Wang S, Sun W, Guo J, Yu C, Wang Y, Kong W, Zheng J. Naringenin inhibits NG-nitro-L-arginine methyl ester-induced hypertensive left ventricular hypertrophy by decreasing angiotensin-converting enzyme 1 expression. Exp Ther Med. 2018 Aug;16(2):867-873
Fu Y, Wang X, Kong W*. Hyperhomocysteinemia and Vascular Injury: The Advance of Mechanisms and Drug Targets. Br J Pharmacol. 2018 Apr;175(8):1173-1189
Xie SA, Zhang T, Wang J, Zhao F, Zhang YP, Yao WJ, Hur SS, Yeh YT, Pang W, Zheng LS, Fan YB, Kong W, Wang X, Chiu JJ, Zhou J. Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: Role of DNA methyltransferase 1. Biomaterials. 2018 Feb;155:203-216
Zhao G, Fu Y, Cai Z, Yu F, Gong Z, Dai R, Hu Y, Zeng L, Xu Q, Kong W*. Unspliced XBP1 Confers VSMC Homeostasis and Prevents Aortic Aneurysm Formation via FoxO4 Interaction. Circ Res. 2017 Dec 8;121(12):1331-1345
Kong W, Du J, Zhu Y, Dong E. Basic and Translational Vascular Research in China: Past, Present, and Future. Circ Res. 2017 Aug 4;121(4):335-337
Yu B, Liu Z, Fu Y, Wang Y, Zhang L, Cai Z, Yu F, Wang X, Zhou J, Kong W*. CYLD Deubiquitinates Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Contributing to Adventitial Remodeling. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1698-1709
Fu Y, Kong W*. Cartilage Oligomeric Matrix Protein: Matricellular and Matricrine Signaling in Cardiovascular Homeostasis and Disease. Curr Vasc Pharmacol. 2017;15(3):186-196
Jia Y, Kong W*. ADAM17: A Molecular Switch to Control TNFR2 During Atherogenesis In Vivo. Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):176-178
Yu H, Jia Q, Feng X, Chen H, Wang L, Ni X, Kong W. Hypoxia decrease expression of cartilage oligomeric matrix protein to promote phenotype switching of pulmonary arterial smooth muscle cells. Int J Biochem Cell Biol. 2017 Aug 30;91(Pt A):37-44
Hong X, Margariti A, Le Bras A, Jacquet L, Kong W, Hu Y, Xu Q. Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration. Sci Rep. 2017 Jul 17;7(1):5590
Liu J, Jia X, Jia S, Qin X, Zhang T, Liu L, Li H, Rong D, Zhou Z, Song Y, Zuo S, Duan C, Wu Z, Wei R, Ge Y, Wang X, Kong W, Xu X, Khalil RA, Huo Y, Guo W. Small infrarenal aortic diameter associated with lower-extremity peripheral artery disease in Chinese hypertensive adults. Sci Rep. 2017 Nov 6;7(1):14547
Wang H, Wu W, Duan J, Ma M, Kong W, Ke Y, Li G, Zheng J. Cardioprotection of ischemic preconditioning in rats involves upregulating adiponectin. J Mol Endocrinol. 2017 May;58(4):155-165
Fu Y, Gao C, Liang Y, Wang M, Huang Y，Ma W，Li T，Jia Y，Yu F，Zhu W，Cui Q，Li Y，Xu Q，Wang X, Kong W*. Shift of Macrophage Phenotype due to Cartilage Oligomeric Matrix Protein Deficiency Drives Atherosclerotic Calcification. Circ Res. 2016 Jul 8;119(2):261-276 (Cover story with editorial comment)
Gao C, Fu Y, Li Y, Zhang X, Zhang L, Yu F, Xu S, Xu Q, Zhu Y, Guan Y, Wang X, Kong W*. Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification. Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):108-121
Yang N, Yu F, Shao G, Fu Y, Kong W*. The E3 ubiquitin ligase c-Cbl mediates integrin β1 ubiquitination during dilated cardiomyopathy. Biochem Biophys Res Commun. 2016 Oct 28;479(4):728-735
Wang M, Fu Y, Gao C, Jia Y, Huang Y, Liu L, Wang X, Wang W, Kong W*. Cartilage oligomeric matrix protein prevents vascular aging and vascular smooth muscle cells senescence. Biochem Biophys Res Commun. 2016 Sep 16;478(2):1006-1013
Ma W, Zhang L, Zeng P, Huang C, Li J, Geng B, Yang J, Kong W, Zhou X, Cui Q. An analysis of human microbe-disease associations. Brief Bioinform. 2017 Jan;18(1):85-97
Zhang J, Wang J, Wei Y, Gao C, Chen X, Kong W, Kong D, Zhao Q. ECM-mimetic heparin glycosamioglycan-functionalized surface favors constructing functional vascular smooth muscle tissue in vitro. Colloids Surf B Biointerfaces. 2016 Oct 1;146:280-288
Simpson RM, Hong X, Wong MM, Karamariti E, Issa Bhaloo S, Warren D, Kong W, Hu Y, Xu Q. Hyaluronan Is Crucial for Stem Cell Differentiation into Smooth Muscle Lineage. Stem Cells. 2016 2016 May;34(5):1225-1238
Liang Y, Fu Y, Qi R, Wang M, Yang N, He L, Yu F, Zhang J, Yun CH, Wang X, Liu J, Kong W*. Cartilage oligomeric matrix protein is a natural inhibitor of thrombin. Blood. 2015 Aug 13;126(7):905-914 (with editorial comment)
Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q, Zhu Y, Wang X, Schmidt K, de Wit C, Erdmann J, Schunkert H, Aherrahrou Z, Kong W*. ADAMTS-7 Inhibits Re-Endothelialization of Injured Arteries and Promotes Vascular Remodeling Via Cleavage of Thrombospondin-1. Circulation. 2015 Mar 31;131(13):1191-1201 (with editorial comment)
Zhang K, Li T, Fu Y, Cui Q, Kong W*. Predicting Abdominal Aortic Aneurysm Target Genes by Level-2 Protein-Protein Interaction. PLoS One. 2015 Oct 23;10(10):e0140888
Wei R, Liu LS, Wang LW, Li YB, Zhang T, Liu J, Zuo SW, Jia SH, Song YX, Wu ZY, Duan C, Ge YY, Li HB, Xiong J, Jia X, Wang X, Kong W, Xu XP, Guo W, Huo Y. Association of Resting Heart Rate with Infrarenal Aortic Diameter: A Cross Sectional Study in Chinese Hypertensive Adults Eur J Vasc Endovasc Surg. 2015 Dec;50(6):714-721
Zhao Y, Zhao MM, Cai Y, Zheng MF, Sun WL, Zhang SY, Kong W, Gu J, Wang X, Xu MJ. Mammalian target of rapamycin signaling inhibition ameliorates vascular calcification via Klotho upregulation. Kidney Int. 2015 Oct;88(4):711-721
Zhang L, Yu F, Wang L, Zheng J, Du Y, Huang Y, Liu B, Wang X, Kong W*. ADAMTS-7 promotes vascular smooth muscle cells proliferation in vitro and in vivo. Sci China Life Sci. 2015 Jul;58(7):674-681
Sun W, Pang Y, Liu Z, Sun L, Liu B, Xu M, Dong Y, Feng J, Jiang C, Kong W*, Wang X*. Macrophage inflammasome mediates hyperhomocysteinemia-aggravated abdominal aortic aneurysm. J Mol Cell Cardiol. 2015 Apr;81:96-106
Li J, Gao C, Wang Y, Ma W, Tu J, Wang J, Chen Z, Kong W, Cui Q. A bioinformatics method for predicting long noncoding RNAs associated with vascular disease. Sci China Life Sci. 2014 Aug;57(8):852-857
Luo H, Liu B, Hu J, Wang X, Zhan S, Kong W*. Hyperhomocysteinemia and Methylenetetrahydrofolate Reductase Polymorphism in Cervical Artery Dissection: A Meta-Analysis. Cerebrovasc Dis. 2014 Jun 4;37(5):313-322
Gao F, Chambon P, Offermanns S, Tellides G, Kong W, Zhang X, Li W. Disruption of TGF-β signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm. Biochem Biophys Res Commun. 2014 Oct 18;454(1):137-143
Gao F, Chambon P, Tellides G, Kong W, Zhang X, Li W. Disruption of TGF-β signaling in smooth muscle cell prevents flow-induced vascular remodeling. Biochem Biophys Res Commun. 2014 Oct 24;454(1):245-250
Dai XY, Cai Y, Sun W, Ding Y, Wang W, Kong W, Tang C, Zhu Y, Xu MJ, Wang X. Intermedin inhibits macrophage foam-cell formation via tristetraprolin-mediated decay of CD36 mRNA. Cardiovasc Res. 2014 Feb 1;101(2):297-305
Gao YX, Yu CA, Lu JH, Gao HM, Li G, Kong W*, Zheng J*. ADAMTS-7 expression increases in the early stage of angiotensin II-induced renal injury in elderly mice. Kidney Blood Press Res. 2013;38(1):121-1231
Huang Y, Xia J, Zheng J, Geng B, Liu P, Yu F, Liu B, Zhang H, Xu M, Ye P, Zhu Y, Xu Q, Wang X, Kong W*. Deficiency of cartilage oligomeric matrix protein causes dilated cardiomyopathy. Basic Res Cardiol. 2013 Sep;108(5):374
Zheng J, Kong W*. Noninvasive imaging of coronary artery disease--myth or reality? Circ J. 2013;77(6):1409-1410
Li Y, Zhang H, Jiang C, Xu M, Pang Y, Feng J, Xiang X, Kong W, Xu G, Li Y, Wang X. Hyperhomocysteinemia Promotes Insulin Resistance by Inducing Endoplasmic Reticulum Stress in Adipose Tissue. J Biol Chem. 2013 Apr 5;288(14):9583-9592
Dai XY, Zhao MM, Cai Y, Guan QC, Zhao Y, Guan Y, Kong W, Zhu WG, Xu MJ, Wang X. Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release. Kidney Int. 2013 Jun;83(6):1042-1051
Ma K, Lv S, Liu B, Liu Z, Luo Y, Kong W, Xu Q, Feng J, Wang X. CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE-/- mice. Cardiovasc Res. 2013 Feb 1;97(2):349-359
Du Y, Gao C, Liu Z, Wang L, Liu B, He F, Zhang T, Wang Y, Wang X, Xu M, Luo GZ, Zhu Y, Xu Q, Wang X, Kong W*. Upregulation of a Disintegrin and Metalloproteinase With Thrombospondin Motifs-7 by miR-29 Repression Mediates Vascular Smooth Muscle Calcification. Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2580-2588
Liu Z, Luo H, Zhang L, Huang Y, Liu B, Ma K, Feng J, Xie J, Zheng J, Hu J, Zhan S, Zhu Y, Xu Q, Kong W*, Wang X*. Hyperhomocysteinemia Exaggerates Adventitial Inflammation and Angiotensin II-Induced Abdominal Aortic Aneurysm in Mice. Circ Res. 2012 Oct 26;111(10):1261-1273. (Cover Story)
Zhang D, Chen Y, Xie X, Liu J, Wang Q, Kong W*, Zhu Y*. Homocysteine activates vascular smooth muscle cells by DNA demethylation of platelet-derived growth factor in endothelial cells. J Mol Cell Cardiol. 2012 Oct;53(4):487-496
Kong W, Zhu Y. The Pleiotropic Effects of Statins in the Prevention of Atherosclerosis: Editorial to: "Simvastatin Suppresses Apoptosis in Vulnerable Atherosclerotic Plaques Through Regulating the Expression of p53, Bcl-2 en Bcl-xL" by Weiwei Qin et al. Cardiovasc Drugs Ther. 2012 Feb;26(1):5-7
Kong W*. Matrix metalloproteinase-9 vs. troponin T. The sooner the better? Circ J. 2011;75(12):2757-2758
Zhao G, Xu MJ, Zhao MM, Dai XY, Kong W, Wilson GM, Guan Y, Wang CY, Wang X. Activation of nuclear factor-kappa B accelerates vascular calcification by inhibiting ankylosis protein homolog expression. Kidney Int. 2012 Jul;82(1):34-44
Zhou Z, Sun W, Liang Y, Gao Y, Kong W, Guan Y, Feng J, Wang X. Fenofibrate inhibited the differentiation of T helper 17 cells in vitro. PPAR Res. 2012;2012:145654
Zhou Z, Liang Y, Gao Y, Kong W, Feng J, Wang X. Fenofibrate enhances the in vitro differentiation of foxp3(+) regulatory T cells in mice. PPAR Res. 2012;2012:529035
Zhang D, Xie X, Chen Y, Hammock BD, Kong W, Zhu Y. Homocysteine upregulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Circ Res. 2012 Mar 16;110(6):808-817
Du Y, Wang Y, Wang L, Liu B, Tian Q, Liu CJ, Zhang T, Xu Q, Zhu Y, Ake O, Qi Y, Tang C, Kong W*, Wang X. Cartilage Oligomeric Matrix Protein Inhibits Vascular Smooth Muscle Calcification by Interacting With Bone Morphogenetic Protein-2. Circ Res. 2011 Apr 15;108(8):917-928
Fu Y, Hou Y, Fu C, Gu M, Li C, Kong W, Wang X, Shyy JY, Zhu Y. A Novel Mechanism of {gamma}/{delta} T-Lymphocyte and Endothelial Activation by Shear Stress: The Role of Ecto-ATP Synthase {beta} Chain. Circ Res. 2011 Feb 18;108(4):410-417
Zhao MM, Xu MJ, Cai Y, Zhao G, Guan Y, Kong W, Tang C, Wang X. Mitochondrial O2.- promoting p65 nuclear translocation mediates high-phosphate-induced vascular calcification in vitro and in vivo. Kidney Int. 2011 May;79(10):1071-1079
Wang L, Zheng J, Du Y, Huang Y, Li J, Liu B, Liu CJ, Zhu Y, Gao Y, Xu Q, Kong W*, Wang X*. Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting with α7β1 Integrin. Circ Res. 2010 Feb 19;106(3):514-525 (with editorial)

Yu Li

Current Position: Professor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
Address: 320 Yue Yang Road, Life Science Research Building A1816, Shanghai, China 200031
Phone: 021-5492-0753
Fax: 021-54920291
Email: liyu@sibs.ac.cn

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2008: PhD Molecular and Cellular Biology University of Guelph, Guelph, Ontario, Canada
2003: MS Fermentation Tianjin University of Science and Technology, China
2000: BS Biological Engineering Tianjin University of Science and Technology, China
2009.03-2013.01: Postdoctoral Fellow, Vascular Biology Section, Whitaker Cardiovascular Institute, Boston University Medical School, Boston, MA, USA
2018.01-present: Professor, Institute of Nutrition and Health, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
2013.01-2017.12: Professor, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

HONORS, PRIZES AND AWARDS
2019 The National Science Fund for Distinguished Young Scholars, NSFC
2017 Lu Jiaxi International Team Member, Chinese Academy of Sciences
2011 Young Investigator Travel Grant Award, American Diabetes Association, USA
2011-2012 CTSI subsidy Award, Clinical Translational Science Institute, Boston University, USA
2009 First Prize of Evans Day Basic Research Award, Boston University, USA
2004-2006 Graduate Scholarship, University of Guelph, Canada
2000-2003 Graduate Scholarship, Tianjin University of Science and Technology
1996-2000 Undergraduate Scholarship, Tianjin University of Science and Technology

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS
Associate Editor
Since 2018 Nutrition & Metabolism
Editorial Board
Since 2018 Obesity Medicine
Ad Hoc Reviewer
Since 2012 PLoS ONE, FEBS Letters, Journal of Agricultural and Food Chemistry
Since 2015 Nat Commun, Hepatology, Autophagy, Med Res Rev, FEBS Letters, Mol Cell
Endocrinol, Frontiers in Pharmacology
Since 2018 Molecular Metabolism, Free Radical Biology and Medicine

SELECTED PUBLICATIONS

Hu Z#, Han Y#, Liu Y, Zhao Z, Ma F, Cui A, Zhang F, Liu Z, Xue Y, Bai J, Wu H, Bian H, Chin YE, Yu Y, Meng Z, Wang H, Liu Y, Fan J, Gao X, Chen Y, Li Y*. CREBZF as a key Regulator of STAT3 Pathway in the Control of Liver Regeneration in Mice. Hepatology. 2020 Apr;71(4):1421-1436
Han Y#, Hu Z#, Cui A, Liu Z, Ma F, Xue Y, Liu Y, Zhang F, Zhao Z, Yu Y, Gao J, Wei C, Li J, Fang J, Li J, Fan JG, Song BL, Li Y*. Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene. Nature Communications. 2019;10(1):623
Wu R, Dang F, Li P, Wang P, Xu Q, Liu Z, Li Y, Wu Y, Chen Y, Liu Y*. The circadian protein period2 suppresses mTORC1 activity via recruiting Tsc1 to mTORC1 complex. Cell Metabolism. 2019;29(3):653-667
Yang Y#, Ma F#, Liu Z, Su Q, Liu Y, Liu Z, Li Y*. The ER-localized Ca2+-binding protein calreticulin couples ER stress to autophagy by associating with microtubule-associated protein 1A/1B light chain 3. Journal of Biological Chemistry. 2019;294(3):772-782
Zhao Z, Xin F, Xue Y, Hu Z, Han Y, Ma F, Zhou D, Liu X, Cui A, Liu Z, Liu Y, Gao J, Pan Q, Li Y*, Fan J*. Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats. Experimental and Molecular Medicine. 2019;51(9):103
Chen X, Zhuo S, Zhu T, Yao P, Yang M, Mei H, Li N, Ma F, Wang J, Chen S, Ye RD, Li Y, Le Y*. (2019) Fpr2 Deficiency Alleviates Diet-Induced Insulin Resistance Through Reducing Body Weight Gain and Inhibiting Inflammation Mediated by Macrophage Chemotaxis and M1 Polarization. Diabetes. 2019;68(6):1130-1142
Xiao F, Guo Y, Deng J, Yuan F, Xiao Y, Hui L, Li Y, Hu Z, Zhou Y, Li K, Han X, Fang Q, Jia W, Chen Y, Ying H, Zhai Q, Chen S, Guo F*. Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals. Molecular Metabolism. 2019;20:138-148
Zhang F, Hu Z, Li G, Huo S, Ma F, Cui A, Xue Y, Han Y, Gong Q, Gao J, Bian H, Meng Z, Wu H, Long G, Tan Y, Zhang Y, Lin X, Gao X, Xu A, Li Y*. Hepatic CREBZF couples insulin to lipogenesis by inhibiting Insig activity and contributes to hepatic steatosis in diet-induced insulin-resistant mice. Hepatology. 2018;68(4):1361-1375
Chen H, Shen F, Sherban A, Nocon A, Li Y, Wang H, Xu MJ, Rui X, Han J, Jiang B, Lee D, Li N, Keyhani-Nejad F, Fan JG, Liu F, Kamat A, Musi N, Guarente L, Pacher P, Gao B, Zang M*. DEPTOR suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease. Hepatology. 2018;68(2):496-514
Sun Y, Xia M, Yan H, Han Y, Zhang F, Hu Z, Cui A, Ma F, Liu Z, Gong Q, Chen X, Gao J, Bian H, Tan Y, Li Y*, Gao X*. Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21. British Journal of Pharmacology. 2018;175(2):374-387
Zhang H, Yan S, Khambu B, Ma F, Li Y, Chen X, Martina JA, Puertollano R, Li Y, Chalasani N, Yin X-M*. Dynamic mtorc1-tfeb feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply. Autophagy. 2018;14(10):1779-1795
Cui A, Hu Z, Han Y, Yang Y, Li Y*. Optimized analysis of In vivo and in vitro hepatic steatosis. Journal of Visualized Experiments. 2017;e55178
Chen L, Wang K, Long A, Jia L, Zhang Y, Deng H, Li Y, Han J, and Wang Y*. Fasting-induced hormonal regulation of lysosomal function. Cell Res. 2017;27:748-763
Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, Gao J, Chen X, Han Y, Liang Q, Ye D, Shi L, Chin YE, Wang Y, Xiao H, Guo F, Liu Y, Zang M, Xu A, Li Y*. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1. Hepatology. 2016;64(2):425-438
Chen X, Zhang F, Gong Q, Cui A, Zhuo S, Hu Z, Han Y, Gao J, Sun Y, Liu Z, Yang Z, Le Y, Gao X, Dong LQ, Gao X, Li Y*. Hepatic ATF6 increases fatty acid oxidation to attenuate hepatic steatosis in mice through peroxisome proliferator-activated receptor alpha. Diabetes. 2016;65(7):1904-1915
Li Y*, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M*. Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21. Gastroenterology. 2014;146:539-549
Li Y*, Wong K, Walsh K, Gao B, Zang M*. Retinoic acid receptor β stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice. Journal of Biological Chemistry. 2013;288:10490-10504
Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JJ, Gao B, Wierzbicki M, Verbeuren TJ, Shaw RJ, Cohen RA, Zang M*. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metabolism. 2011;13:376-388
Li Y, Xu S, Giles A, Nakamura K, Lee JW, Hou X, Donmez G, Li J, Luo Z, Walsh K, Guarente L, Zang M. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB Journal. 2011;25:1664-1679

Xiaowen Liang

Address: 338 Ferguson Rd, Norman Park QLD 4170, Australia
Mobile: +61 4 5217 8815
Email: x.liang@uq.edu.au

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2018.10-present: Research Fellow (Promote to Level B), The University of Queensland Diamantina Institute, UQ
2015.09-2018.09: Research Officer, The University of Queensland Diamantina Institute, UQ
2011.09-2015.04: PhD in Medicine, The University of Queensland, QLD, Australia
2008.09-2011.07: MS in Pharmacology, Nanjing University of Chinese Medicine, Nanjing, P.R. China
2004.09-2008.07: BSc in Pharmacy, Nanjing University of Chinese Medicine, Nanjing, P.R. China

HONORS, PRIZES AND AWARDS
2018.12: Abstract of Merit, Research Workshop. Gastroenterological Society of Australia
2018.11: Gallipoli Bursar, Gastroenterological Society of Australia
2018.10-present: Early Career Researcher Committee Member, Faculty of Medicine, UQ
2015.09-present: Ambassador, The European Association for Cancer Research (EACR)
2016.09: Posters of Excellence, United European Gastroenterology Week 2016

SELECTED PUBLICATIONS

I have achieved 37 publications (7 as first author and 11 as corresponding author) and 4 book chapters. 50% of my publications (articles and reviews) are published in the top 10% of Quartile 1 journals and 100% of my ten career-best publications are within the top 10 journal percentile (SciVal 2019). My publications have attracted over 300 citations in the past 6 years (based on Scopus Feb 2019) and my H-index is 12. My Field-Weighted Citation Impact (FWCI) (article and reviews) is 1.64 (SciVal 2019). My FWCI for my 10 best publications is 3.36, indicating these articles are cited more than twice the global average based on citations accrued (SciVal 2019).

Lu Zhang, Huilan Su, Haolu Wang, Qian Li, Xiao Li, Chuanqing Zhou, Jia Xu, Yimin Chai, Xiaowen Liang, Liqin Xiong, Chunfu Zhang. Tumor chemo-radiotherapy with rod-shaped and spherical gold nano probes: shape and active targeting both matter. Theranostics 2019;9(7):1893-1908
Wenjin Xiao, Thomas I P Green, Xiaowen Liang (co-first), Rosalia Cuahtecontzi Delint, Guillaume Perry, Michael S Roberts, Kristian Le Vay, Catherine R Back, Raimomdo Ascione, Haolu Wang, Paul R Race, Adam W Perriman. Designer artificial membrane binding proteins to direct stem cells to the myocardium. Chem Sci 2019 Jul 3;10(32):7610-7618
H Yang, RM Villani, H Wang. MJ Simpson, MS Roberts, M Tang, X Liang (corresponding author). The role of cellular reactive oxygen species in cancer chemotherapy. J Exp Clin Cancer Res 2018 Nov 1;37(1):266
H Wang, H Yang, Z Xu, X Liu, MS Roberts, X Liang (corresponding author). Anionic Long-Circulating Quantum Dots for Long-Term Intravital Vascular Imaging. Pharmaceutics 2018;10(4):244
H Wang, X Li, BW Tse, H Yang, CA Thorling, Y Liu, M Touraud, JB Chouane, X Liu, MS Roberts, X Liang (corresponding author). Indocyanine green-incorporating nanoparticles for cancer theranostics. Theranostics 2018;8(5):1227
H He, Y Liu, Z Zhou, C Guo, HY Wang, Z Wang, X Wang, Z Zhang, FG Wu, Wang H, Chen D, Yang D, Liang X (co-corresponding author), Chen J, Zhou S, Liang X, Qian X, Yang Y. A Photo-triggered and photo-calibrated nitric oxide donor: Rational design, spectral characterizations, and biological applications. Free Radic Biol Med 2018 Aug 1;123:1-7
X Luo, H Yang, H Wang, Z Ye, Z Zhou, L Gu, J Chen, Y Xiao, X Liang (co-corresponding author), X Qian, Y Yang. Highly Sensitive Hill-Type Small-Molecule pH Probe That Recognizes the Reversed pH Gradient of Cancer Cells. Anal Chem 2018 May 1;90(9):5803-5809
H He, Y Xia, Y Qi, HY Wang, Z Wang, J Bao, Z Zhang, FG Wu, H Wang, D Chen, D Yang, Liang X (co-corresponding author), J Chen, S Zhou, X Liang, X Qian, Y Yang. A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications. Bioconjug Chem 2018;29(4):1194-1198
H Wang, R Zhang, KR Bridle, A Jayachandran, JA Thomas, W Zhang, J Yuan, ZP Xu, DHG Crawford, X Liang (co-corresponding author), X Liu, MS Roberts. Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury. Sci Rep 2017 Mar 28;7:45374
X Li, S Teng, Y Zhang, W Zhang, X Zhang, K Xu, H Yao, J Yao, H Wang, X Liang (co-corresponding author), Z Hu. TROP2 promotes proliferation, migration and metastasis of gallbladder cancer cells by regulating PI3K/AKT pathway and inducing EMT. Oncotarget 2017;8(29):47052-47063
X Li, W Zhang, X Zhang, H Wang, K Xu, H Yao, J Yao, X Liang (co-corresponding author), Z Hu. The prognostic value of negative lymph node count for patients with gastric cancer who received preoperative radiotherapy. Oncotarget 2017;8(29):46946-46954
X Li, H Lu, K Xu, H Wang, X Liang (co-corresponding author), Z Hu. Negative lymph node count is an independent prognostic factor for patients with rectal cancer who received preoperative radiotherapy. BMC Cancer 2017;17(1):227
X Liang, H Wang, JE Grice, L Li, X Liu, ZP Xu, MS Roberts. A physiologically based pharmacokinetic model for long-circulating nanoparticles. Nano Letters (IF 13.7) 2016;16(2):939–945
X Liang, H Wang, Y Zhu, R Zhang, VC Cogger, X Liu, ZP Xu, JE Grice, MS Roberts. Short- and long-term tracking of anionic ultra-small nanoparticles in kidney. ACS Nano 2016;10(1):387–395
H Wang*, X Liang* (co-first author), ZP Xu, DHG Crawford, X Liu, MS Roberts. A physiologically based kinetic model for elucidating the in vivo distribution of administered mesenchymal stem cells. Scientific Reports 2016;6:22293
H Wang*, X Liang* (co-first author), YH Mohammed, JA Thomas, KR Bridle, CA Thorling, JE Grice, ZP Xu, X Liu, DHG Crawford. MS Roberts. Real-time histology in liver disease using multiphoton microscopy with fluorescence lifetime imaging. Biomedical Optics Express 2015;6(3):780-792
X Liang, JE Grice, Y Zhu, D Liu, WY Sanchez, Z Li, DHG Crawford, DGL Couteur, CC Victoria, X Liu, ZP Xu, MS Roberts. Intravital multiphoton imaging of the selective uptake of water-dispersible quantum dots into sinusoidal liver cells. Small 2014;11(14):1711-1720
X Liang, ZP Xu, JE Grice, AV Zvyagin, MS Roberts, X Liu. Penetration of nanoparticles into human skin. Current Pharmaceutical Design 2013;19(35):6353-6366

Baohua Liu

Professor, Biochemistry & Molecular Biology
Deputy Director, Medical Research Center
Associate Dean, School of Basic Medical Sciences
Shenzhen University Health Science Center
Tel: (86)-755-2691 5563
Email: ppliew@szu.edu.cn; ihavey@gmail.com
ORCID: https://orcid.org/0000-0002-1599-8059

BIOGRAPHY
Dr Liu earned his B.S. degree from Peking University in 1999, and Ph.D. degree at the University of Hong Kong in 2007. He completed postdoctoral training at the University of Hong Kong and was promoted to Research Assistant Professor in 2011. In 2014, Dr Liu joined Shenzhen University as a Distinguished Professor. During his career, Dr Liu has received awards including Li Ka Shing Prize, the National Excellent Young Researcher Award. His research interests are centered on mechanisms and interventions of aging.

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS
Chief Secretary, Asian Society for Aging Research (ASAR), 2011-
Executive Committee, Chinese Society for Matrix Biology (CSMB), 2016-
Executive Committee, Basic and Translational Branch, Chinese Geriatrics Society, 2015-
Scientific Committee, China Association of Gerontology and Geriatrics (CAGG), 2017-
Scientific Committee, Chinese Society of Aging Biology (CSAB), 2017-
Standing Committee, the First Committee of Orthopedic Research Society, International Society of Orthopaedic Surgery and Traumatology (SICOT) China Chapter, 2015-
Scientific Committee, Chinese Orthopaedic Association, 2014-2017
Scientific Committee, Gerontological Society of China, 2013-2019
Executive Committee, Neuroscience Society of Guangdong Province, China, 2014-

SELECTED PUBLICATIONS (*corresponding authorship, #equal contribution)

Meng F#, Qian M#, Peng B#, Peng L, Wang X, Zheng K, Liu Z, Tang X, Zhang S, Sun S, Cao X, Pang Q, Zhao B, Ma W, Songyang Z, Xu B, Zhu WG, Xu X*, Liu B*. Synergy Between SIRT1 and SIRT6 Helps Recognize DNA Breaks and Potentiates the DNA Damage Response and Repair in Humans and Mice. Elife. 2020 Jun 15;9:e55828
Wang M, Wang L, Qian M, Tang X, Liu Z, Lai Y, Ao Y, Huang Y, Meng Y, Shi L, Peng L, Cao X, Wang Z, Qin B, Liu B*. PML2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome. Aging Cell, 2020 Jun;19(6):e13147
Peng L#, Qian M#*, Liu Z, Tang X, Sun J, Jiang Y, Sun S, Cao X, Pang Q, Liu B*. Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis. Nucleic Acids Research, 2020 May 21;48(9):4992-5005
Sun S#, Qin W#, Tang X#, Meng Y, Hu W, Zhang S, Qian M, Liu Z, Cao X, Pang Q, Zhao B, Wang Z, Zhou Z, Liu B*. Vascular endothelium-targeted Sirt7 gene therapy rejuvenates aging tissues and extends lifespan in Hutchinson-Gilford progeria model. Sci Adv, 2020 Feb 19;6(8):eaay5556
Tang X, Li G, Su F, Cai Y, Shi L, Meng Y, Liu Z, Sun J, Wang M, Qian M, Wang Z, Xu X, Cheng YX, Zhu WG, Liu B*. HDAC8 cooperates with SMAD3/4 complex to suppress SIRT7 and promote cell survival and migration. Nucleic Acids Res, 2020 Apr 6;48(6):2912-2923
Liu Z#, Qian M#, Tang X, Hu W, Sun S, Li G, Zhang S, Meng F, Cao X, Sun J, Xu C, Tan B, Pang Q, Zhao B, Wang Z, Guan Y, Ruan X, Liu B*. SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis. Nat Metab, 2019 Nov;1(11):1141-1156
Ao Y#, Zhang J#, Liu Z, Qian M, Li Y, Wu Z, Sun P, Wu J, Bei W, Wen J, Wu X, Li F, Zhou Z, Zhu WG, Liu B*, Wang Z*. Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model. Sci Adv, 2019 Mar 20;5(3):eaav5078
Shi L#, Tang X#, Qian M, Liu Z, Meng F, Fu L, Wang Z, Zhu WG, Huang JD, Zhou Z, Liu B*. A SIRT1-centered circuitry regulates breast cancer stemness and metastasis. Oncogene, 2018 Dec;37(49):6299-6315
Qian M#, Liu Z#, Peng L, Tang X, Meng F, Ao Y, Zhou M, Wang M, Cao X, Qin B, Wang Z, Zhou Z, Wang G, Gao Z, Xu J, Liu B*. Boosting ATM Activity alleviates ageing and extends lifespan in a mouse model of progeria. Elife, 2018 May 2;7:e34836
Tang X#, Shi L#, Xie N#, Liu Z, Qian M, Meng F, Xu Q, Zhou M, Cao X, Zhu WG, Liu B*. SIRT7 Antagonizes TGF-β Signaling and Inhibits Breast Cancer Metastasis. Nat Commun, 2017 Aug 22;8(1):318
Liu B, Wang Z, Zhang L, Ghosh S, Zheng H, Zhou Z*. Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model. Nat Commun, 2013;4:1868
Liu B*, Ghosh S, Yang X, Zheng H, Liu X, Wang Z, Jin G, Zheng B, Kennedy BK, Suh Y, Kaeberlein M, Tryggvason K, Zhou Z*. Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria. Cell Metab, 2012 Dec 5;16(6):738-750

Huirong Liu

Professor, Director of the department of Physiology & Pathophysiology, School of Basic Medical Sciences, Capital Medical University
Contact information: Room 183, Jieping Building, 10 Xitoutiao You'anmen Wai, Fengtai District, Beijing, 100069, P. R. China
Tel. 86-10-83911830
E-mail: liuhr2000@126.com

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2009-Present Professor Department of Physiology and Pathophysiology, Capital Medical University, Beijing
2002-2009 Professor Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi
2001-2004 Postdoctoral Fellow Department of Emergency Medicine, Cooperative researcher Thomas Jefferson University, PA, Philadelphia
1998-2001 Associate Professor Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi
1995-1998 Lecturer Department of Physiology, Shanxi Medical University, Taiyuan, Shanxi
1985-1992 Attending Physician Department of Clinical Laboratory, Taigang General Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi
1981-1984 Assistant Changzhi Medical College, changzhi, Shanxi
1999.07 Ph.D. Shanxi Medical University, Taiyuan, Shanxi Physiology
1995.07 M.S. Shanxi Medical University, Taiyuan, Shanxi Immunology
1981.01 M.B. Changzhi Medical College, Changzhi, Shanxi Medicine

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS
Acta Pharmacologica Sinica, Acta Physiologica Sinica, Age, Apoptosis, Chemistry of Life, Hypertension, International Journal of Cardiology, JRAAS, Plos One, Progress in Physiological Sciences.

SELECTED PUBLICATIONS

Dan Liu, Linguo Wu, Ye Wu, Xin Wei, Wen Wang, Suli Zhang, Ming Yi, Jing Li*, Huirong Liu*, Xinliang Ma. Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart. Aging (Albany NY). 2019;11(20):8982-8997
Sun Y, Zhang S, Yue M, Li Y, Bi J, Huirong Liu*. Angiotensin II inhibits apoptosis of mouse aortic smooth muscle cells through regulating the circNRG-1/miR-193b-5p/NRG-1 axis. Cell Death Dis. 2019;10(5):362
Wenli Xu, Ye Wu, Li Wang, Yan Bai, Yunhui Du, Yang Li, Ning Cao, Yuhui Zhao, Youyi Zhang, Huirong Liu*. Autoantibody against beta1-adrenoceptor promotes the differentiation of natural regulatory T cells from activated CD4+ T cells by up-regulating AMPK-mediated fatty acid oxidation. Cell death & disease. 2019;10(3):158
Ning Cao, Hao Chen, Yan Bai, Xiaochun Yang, Wenli Xu, Weiwei Hao, Yi Zhou, Jiayin Chai, Ye Wu, Zhaojia Wang, Xiaochen Yi, Linguo Wu, Wen Wang*, Huirong Liu*, Michael LX Fu. β2-adrenergic receptor autoantibodies alleviate myocardial damage induced by β1-adrenergic receptor autoantibodies in heart failure. Cardiovasc Res. 2018 Sep 1;114(11):1487-1498
Li Wang, Yang Li, Na Ning, Jin Wang, Zi Yan, Suli Zhang, Xiangying Jiao, Xiaohui Wang, Huirong Liu*. Decreased autophagy induced by β -adrenoceptor autoantibodies contributes to cardiomyocyte apoptosis. Cell Death Dis. 2018;9(3):406
K Wang, Y Yuan, X Liu, B Wayne, L Zuo, X Wang, L Ma, K Jiao, J Shang, W Wang, X Ma, H Liu*. Cardiac specific overexpression of mitochondrial Omi/HtrA2 induces myocardial apoptosis and cardiac dysfunction. Scientific report. 2016;6:37927
Tingting Lv, Yunhui Du, Ning Cao, Suli Zhang, Yulin Gong, Yan Bai, Wen Wang, Huirong Liu*. Proliferation in cardiac fibroblasts induced by β1-adrenoceptor autoanibody and the underlying mechanisms. Scientific report. 2016;6:32430
L Wang, H Hao, J Wang, X Wang, S Zhang, Y Du, T Lv, L Zuo, Y Li, H Liu*. Decreased autophagy: a major factor for cardiomyocyte death induced by β1-adrenoceptor autoantibodyies. Cell Death Dis. 2015;6:e1862
Jie Yang, Li Li, Jianyu Shang, Lin Cai, Li Song, Suli Zhang, Hao Li, Xiao Li, Wayne Bond Lau, Xinliang Ma, Huirong Liu*. Angiotensin II Type 1 Receptor Autoantibody as a Novel Negative Regulator of Aldosterone independent of Preeclampsia. Journal of Hypertension. 2015;33(5):1046-1056
Ke Wang, Jie Zhang, Jingyi Liu, Jue Tian, Ye Wu, Xiaoliang Wang, Lin Quan, Haibo Xu, Wen Wang, Huirong Liu*. Variations in the Protein Level of Omi/HtrA2 in the Heart of Aged Rats may Contribute to the Increased Susceptibility of Cardiomyocytes to Ischemia/Reperfusion Injury and Cell Death. Age (Dordr). 2013;35(3):733-746
Zhang S, Zhang X, Yang L, Yan Z, Yan L, Tian J, Li X, Song L, Wang L, Yang X, Zheng R, Lau W, Ma XL, Liu H*. Increased Susceptibility to Metabolic Syndrome in Adult Offspring of Angiotensin Type 1 Receptor Autoantibody-Positive Rats. Antioxid Redox Signal. 2012;17(5):733-743
Zuo L, Bao H, Tian J, Wang X, Zhang S, He Z, Yan L, Zhao R, Ma XL*, Liu HR*. Long-term active immunization with a synthetic peptide corresponding to the second extracellular loop of beta(1)-adrenoceptor induces both morphological and functional cardiomyopathic changes in rats. Int J Cardiol. 2011;149(1):89-94

Lingbo Liu

Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Email: lingboliu64@qq.com or liulingbo@hust.edu.cn

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2017.11-present Grade III Professor Institute of Hematology, Union Chief Physician Hospital, Tongji Medical College, Ph.D. graduate tutor Huazhong University of Science Technology
2012.11-2017.10 Professor Institute of Hematology, Union Chief Physician Hospital, Tongji Medical College, Ph.D. graduate tutor Huazhong University of Science Technology
2003.07-2012.10 Associate professor Institute of Hematology, Union associate chief physician Hospital,Tongji Medical College, Master's degree tutor Huazhong University of Science Technology
1995.08-2003.06 Lecturer Institute of Hematology, Union, Physician-in-charge Hospital,Tongji Medical College, Huazhong University of Science Technology
1984.08-1992.08 Resident physician 9th Hospital,Wuhan, P. R. China
2001.07 Ph.D., Tongji Medical College, Huazhong Hematology, University of Science and Technology
1995.07 M.S., Tongji Medical College, Huazhong Hematology, University of Science and Technology
1984.07 M.B. (M.D.), Tongji Medical College, Huazhong Medicine, University of Science and Technology; Research Associate Department of Pathology and Laborary Medicine; (Post doctoral fellow) Medical University of South Carolina
2006-2007 Charleston SC，USA

SELECTED PUBLICATIONS

Danyue Peng, Huifang Wang, Lei Li, Xiao Ma, Ying Chen, Hao Zhou1, Yi Luo, Yin Xiao, Lingbo Liu. miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding. Leukemia 2018 May;32(5):1180-1188
Shao L, Feng W, Li H, Gardner D, Luo Y, Wang Y, Liu L, Meng A, Sharpless NE, Zhou D. Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner. Blood 2014 May 15;123(20):3105-3115
Luo Y, Li L, Zou P, Wang J, Shao L, Zhou D, Liu L. Rapamycin Enhances Long-Term Hematopoietic Reconstitution of Ex Vivo Expanded Mouse Hematopoietic Stem Cells by Inhibiting Senescence. Transplantation 2014 Jan 15;97(1):20-29
Yin Xiao, Jie Wang, Hui Song, Ping Zou, Daohong Zhou，Lingbo Liu. CD34+ cells from patients with myelodysplastic syndrome present different p21 dependent premature senescence. Leukemia Research 2013;37:333-340
Jing Zou, Ping Zou, Jie Wang, Lei Li, Yong Wang, Daohong Zhou, Lingbo Liu. Inhibition of p38 MAPK Activity Promotes ex vivo Expansion of Human Cord Blood Hematopoietic Stem Cells. Annals of Hematology 2012;91:813-823
Luo Y, Zou P, Zou J, Wang J, Zhou D, Liu L. Autophagy regulates ROS-induced cellular senescence via p21 in a p38 MAPKα dependent manner. Exp Gerontol. 2011 Nov 23;46(11):860-867
Wang Y, Liu L, Pazhanisamy SK, Li H, Meng A, Zhou D. Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells. FREE RADICAL BIO MED 2010;48:348-356
Wang Y, Liu L, Zhou D. Inhibition of p38 MAPK Attenuates Ionizing Radiation-Induced Hematopoietic Cell Senescence and Residual Bone Marrow Injury. Radiat Res 2011 Dec;176(6):743-752
Wang Y, Kellner J, Liu L, Zhou D. Inhibition of p38 mitogen-activated protein kinase promotes ex vivo hematopoietic stem cell expansion. Stem Cells Dev 2011 Jul;20(7):1143-1152

Sumei Liu

Address: Department of Biology, University of Wisconsin-La Crosse, 3010 Cowley Hall, 1725 State Street, La Crosse, WI 54601, USA
Tel: (608) 785-6971
Email: sliu@uwlax.edu

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2017-present: Professor, Science and Allied Health, University of Wisconsin-La Crosse
2013-2017: Associate professor, Science and Allied Health, University of Wisconsin-La Crosse
2009-2013: Assistant professor, Science and Allied Health, University of Wisconsin-La Crosse
2005-2009: Assistant professor, Ohio State University, Columbus, OH (Gastroenterology)
2005-2009: Assistant professor, Ohio State University, Columbus, OH (Physiology and Cell Biology)
2002: Ph.D. Ohio State University, Columbus, OH (Physiology and Cell Biology)
1993: M.S. Beijing Normal University, Beijing, China (Physiology)
1990: B.S. Beijing Normal University, Beijing, China (Biology)

RESEARCH AREAS
(1) Effects of stress on gastrointestinal function
(2) Effects of hibernation on gastrointestinal motility
(3) Using novel technology of micro vibration to strengthen skeletal muscle and bone

SELECTED PUBLICATIONS

Liu S. Neurotrophic factors in enteric physiology and pathophysiology. Neurogastroenterol Motil. 2018 Oct;30(10):e13446
Liu S, Hagiwara SI, Bhargava A. Early-life adversity, epigenetics, and visceral hypersensitivity. Neurogastroenterol Motil 2017 Sep;29(9):e13170
Liu S, Chang J, Long N, Beckwith K, Talhouarne G, Brooks, JJ, Qu M-H, Ren W, Wood JD, Cooper S, Bhargava A. Endogenous CRF in rat large intestine mediates motor and secretory responses to stress. Neurogastroenterol Motil 2016;28(2):281-291
Wang GD, Wang XY, Liu S, Xia Y, Zou F, Qu M, Needleman BJ, Mikami DJ, Wood JD. β-Nicotinamide adenine dinucleotide acts at prejunctional adenosine A1 receptors to suppress inhibitory musculomotor neurotransmission in guinea pig colon and human jejunum. Am J Physiol Gastrointest Liver Physiol 2015;308(11):G955–G963
Wang GD, Wang XY, Liu S, Qu M, Xia Y, Needleman BJ, Mikami DJ, Wood JD. Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine. Am J Physiol Gastrointest Liver Physiol 2014;307(7):G719-G731
Wang GD, Wang XY, Zou F, Qu M, Liu S, Fei G, Xia Y, Needleman BJ, Mikami DJ, Wood JD. Mast cell expression of the serotonin 1A receptor in guinea pig and human intestine. Am J Physiol Gastrointest Liver Physiol 2013 304(10):G855-G863
Fei G, Fang X, Wang GD, Liu S, Wang XY, Xia Y, Wood JD. Neurogenic mucosal bicarbonate secretion in guinea pig duodenum. Br J Pharmacol 2013;168(4):880-890
Ji T, Liu S, Zheng LF, Wang Q, Dou ZF, Zhang Y, Zhu JX. Cellular distribution of NKCC2 in the gastric mucosa and its response to short-term osmotic shock. Cell and Tissue Research 2012;348(1):155-165
Xu JD#, Liu S#, Wang W, Li LS, Li XF, Li Y, Guo H, Hou XL, Zhang Y, Zhu J-X. Emodin induces chloride secretion in rat distal colon through activation of mast cells and enteric neurons. Br J Pharmacol 2012;165(1):197-207 (#Both authors contributed equally to this work)
Wood JD, Liu S, Drossman DA, Ringel Y, Whitehead, WE. Anti-Enteric Neuronal Antibodies and the Irritable Bowel Syndrome. J Neurogastroenterol Motil 2012;18(1):78-85
Sun X, Wang X, Wang GD, Xia Y, Liu S, Qu M, Needleman BJ, Mikami DJ, Scott Melvin W, Bohn LM, Ueno R, Wood JD. Lubiprostone Reverses the Inhibitory Action of Morphine on Mucosal Secretion in Human Small Intestine. Dig Dis Sci 2011;56(2):330-338
Zhang XH, Ji T, Guo H, Liu SM, Li Y, Zheng LF, Zhang Y, Zhang XF, Duan ZP, Zhu JX. Expression and activation of β-adrenoceptors in the colorectal mucosa of rat and human. Neurogastroenterol Motil 2010;22(11):e325-e334
Fei G, Raehal K, Liu S, Qu M, Sun X, Wang GD, Wang XY, Xia Y, Schmid CL, Bohn LM, Wood JD. Lubiprostone (SPI-0211) reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse. J Pharmacol Exp Ther 2010;334(1):333-340
Yang N#, Liu SM#, Zheng LF, Ji T, Li Y, Mi XL, Xue H, Ren W, Xu JD, Zhang XH, Li LS, Zhang Y, Zhu JX. Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon. Br J Pharmacol 2010;159(8):1623-1635. (#Both authors contributed equally to this work)
Liu S, Ren W, Qu M-H, Bishop GA, Wang GD, Wang XY, Xia Y, Wood JD. Differential Actions of Urocortins on Neurons of the Myenteric Division of the Enteric Nervous System in Guinea Pig Distal Colon. British Journal of Pharmacology 2010;159(1):222-236

BOOK CHAPTERS

Li S, Fei G, Liu S. Rome IV, The Functional Gastrointestinal Disorders (Chinese edition). China Science Press, 4th ed. Vol 1, pp 59. ISPN: 9787030502179. 2016
Liu S. Enteric Nervous System, in “Progress in Physiology”. Editors: Jianjun Wang and Xiaomin Wang. Higher Education Press, Beijing, China. ISBN: 9787040398359. 2014
Liu S, Wood JD. Neurobiology of stress, in “Physiology of the Gastrointestinal Tract”, 5th ed. Editors: Johnson, Barrett, Ghishan, Merchant, Said, and Wood. Academic Press, Maryland Heights, MO. ISPN: 9780123820266. 2012
Liu S, Wood JD. Neurobiology of corticotropin-releasing factor in the enteric nervous system during stress, in “Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract: Mechanisms, Prevention and Treatment”. Frontiers in Gastrointestinal Research. Editors: Filaretova LP, Takeuchi K. Basel, Karger, vol 30, pp 115–123. ISBN: 9783318021837. 2012
Fei G, Ke MY, Liu S. Rome III, The Functional Gastrointestinal Disorders (Chinese edition). China Science Press, ISPN: 9787030213143. 2008

Xin Ni

Work Address: 88 Xiangya Rd, Xiangya Hospital, Changsha, Hunan Province, China
Tel: +86-13386277132
Email: xinni2018@csu.edu.cn, nixinsmmu@hotmail.com

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2019.01-current: Executive Director and Professor, Research Centre for Molecular Metabolomics, Xiangya Hospital, Central South University
2005.03-2018.12: Chair, Department of Physiology, Second Military Medical University
2000.09-2018.12: Professor, Department of Physiology, Second Military Medical University
2001.03-2001.09: Visiting professor, Mothers and Babies Research Centre (MBRC), Hunter Medical Research Institute, University of Newcastle, Australia
1999.06-2005.03: Vice-chair, Department of Physiology, Second Military Medical University, Shanghai, P.R.China
1999.01-2000.08: Associate professor, Department of Physiology, Second Military Medical University, Shanghai, P.R.China
1994.12-1999.12: Associate professor, Department of Neurobiology, Second Military Medical University, Shanghai, P.R.China
1995.06-1997.07: Visiting scholar, Mothers and Babies Research Centre (MBRC) Hunter Medical Research Institute, University of Newcastle, Australia
1991.07-1994.12: Lecture, Department of Neurobiology, Second Military Medical University, Shanghai, P.R.China
1991: Ph.D. (Physiology) The Second Military Medical University, Shanghai, China
1988: M.S. (Physiology) The Second Military Medical University, Shanghai, China
1985: Bachelor of Medicine The Second Military Medical University, Shanghai, China

HONORS, PRIZES AND AWARDS
2013: Excellent Mater thesis award (supervisor)
2012: Excellent Mater thesis award (supervisor)
2009: Excellent leader of discipline awarded by Shanghai Municipals
2009: Excellent PhD thesis award (supervisor)
2009: Outstanding Academic Leader of Disciplines awarded by Shanghai Municipal Government
2008: Excellent PhD thesis award (supervisor)
2007: Outstanding teacher awarded by PLA
2006：Second class of special allowance for excellent scientists in PLA
2005: Third class of special allowance for excellent scientists in PLA
2004: Excellent Master thesis award (supervisor)
2002: Outstanding young teacher awarded by Second Military Medical University

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS
1996.06-present: Member, The Endocrine Society
2008.09-present: Member, American Physiological Society
2014-2018: President, The Shanghai Association of Physiological Sciences
2010-present: Executive member of council, The Chinese Association of Physiological Sciences

SELECTED PUBLICATIONS

Huang T, Yin H, Ning W, Wang X, Chen C, Lin W, Li J, Zhou Y, Peng Y, Wang M, Ni X*, Zhang W*. Expression of inflammasomes NLRP1, NLRP3 and AIM2 in different pathologic classification of lupus nephritis. Clin Exp Rheumatol Jul-Aug 2020;38(4):680-690
Zhou Y, Zhu X, Wang X, Peng Y, Du J, Yin H, Yang H, Ni X*, Zhang W*. H2S alleviates renal injury and fibrosis in response to unilateral ureteral obstruction by regulating macrophage infiltration via inhibition of NLRP3 signaling. Exp Cell Res 2020 Feb 1;387(1):111779
Wu T, Huang Y, Gong Y, Xu Y, Lu J, Sheng H, Ni X. Treadmill Exercise Ameliorates Depression-Like Behavior in the Rats With Prenatal Dexamethasone Exposure: The Role of Hippocampal Mitochondria. Front Neurosci 2019 Mar 26;13:264
Xu YJ, Sheng H, Wu TW, Bao QY, Zheng Y, Zhang YM, Gong YX, Lu JQ, You ZD, Xia Y, Ni X*. CRH/CRHR1 mediates prenatal synthetic glucocorticoid programming of depression-like behavior across 2 generations. FASEB J 2018 Aug;32(8):4258-4269
Wang C, Du J, Du S, Liu Y, Li D, Zhu X, Ni X*. Endogenous H2S resists mitochondria-mediated apoptosis in the adrenal glands via ATP5A1 S-sulfhydration in male mice. Mol Cell Endocrinol 2018 Oct 15;474:65-73
Sun Q, Chen Z, He P, Li Y, Ding X, Huang Y, Gu H, Ni X. Reduced Expression of Hydrogen Sulfide-Generating Enzymes Down-Regulates 15-Hydroxyprostaglandin Dehydrogenase in Chorion during Term and Preterm Labor. Am J Pathol 2018 Jan;188(1):63-71
Zhang Y, Zheng Y, Xu Y, Sheng H, Ni X*. Corticotropin-Releasing Hormone Suppresses Synapse Formation in the Hippocampus of Male Rats via Inhibition of CXCL5 Secretion by Glia. Endocrinology 2018 Feb 1;159(2):622-638
Hu TX, Guo XJ , Wang G, Sun QQ, He P, Gu H, Huang Y, Gao L, Ni X*. MiR133b is involved in endogenous hydrogen sulfide suppression of sFlt-1 production in human placenta. Placenta 2017 Apr;52:33-40
You X, Chen Z, Zhao H, Xu C, Liu W, Sun Q, He P, Gu H, Ni X*. Endogenous hydrogen sulfide contributes to uterine quiescence during pregnancy. Reproduction 2017 May;153(5):535-543
Tang XL, Wang CN, Zhu XY*, Ni X*. Protein tyrosine phosphatase SHP-1 modulates osteoblast differentiation through direct association with and dephosphorylation of GSK3β. Mol Cell Endocrinol 2017 Jan 5;439:203-212
Duan GL, Wang CN, Liu YJ, Yu Q, Tang XL, Ni X*, Zhu XY*. Resveratrol alleviates endotoxemia-associated adrenal insufficiency by suppressing oxidative/nitrative stress. Endocr J 2016;63(6):569-580
Du JK, Cong BH, Yu Q, Wang H, Wang L, Wang CN, Tang XL, Lu JQ, Zhu XY, Ni X*. Upregulation of microRNA-22 contributes to myocardial ischemia-reperfusion injury by interfering with the mitochondrial function. Free Radic Biol Med 2016 Jul;96:406-417
Wang Y, Xu Y, Sheng H, Ni X, Lu J. Exercise amelioration of depression-like behavior in OVX mice is associated with suppression of NLRP3 inflammasome activation in hippocampus. Behav Brain Res 2016 Jul 1;307:18-24
Hu TX, Wang G, Guo XJ, Sun QQ, He P, Gu H, Huang Y, Gao L, Ni X*. MiR 20a,-20b and -200c are involved in hydrogen sulfide stimulation of VEGF production in human placental trophoblasts. Placenta 2016 Mar;39:101-110
Xu Y, Sheng H, Bao Q, Wang Y, Lu J, Ni X*. NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice. Brain Behav Immun 2016 Aug;56:175-186
Cao B, Yu Q, Zhao W, Tang Z, Cong B, Du J, Lu J, Zhu X*, Ni X*. Kallikrein-related peptidase 8 is expressed in myocardium and induces cardiac hypertrophy. Sci Rep 2016 Jan 29;7:20024
Tang Z, Wang Y, Zhu X, Ni X, Lu J. Exercise Increases Cystathionine-γ-lyase Expression and Decreases the Status of Oxidative Stress in Myocardium of Ovariectomized Rats. Int Heart J 2016;57(1):96-103
Zheng Y, Zhang YM, Ni X*. Urocortin 2 But Not Urocortin 3 Promotes the Synaptic Formation in Hipppocampal Neurons via Induction of NGF Production by Astrocytes. Endocrinology 2016 Mar;157(3):1200-1210
Nadeau-Vallée M, Quiniou C, Palacios J, Hou X, Erfani A, Madaan A, Sanchez M, Leimert K, Boudreault A, Duhamel F, Rivera JC, Zhu T, Noueihed B, Robertson SA, Ni X, Olson DM, Lubell W, Girard S, Chemtob S. Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth. J Immunol 2015 Oct 1;195(7):3402-3415
Chen Z, He P, Ding X, Huang Y, Gu H, Ni X*. PPARγ stimulates expression of L-type amino acid and taurine transporters in human placentas: the evidence of PPARγ regulating fetal growth. Sci Rep 2015 Jul 31;5:12650
Tang XL, Wang CN, Zhu XY, Ni X*. Rosiglitazone inhibition of calvaria-derived osteoblast differentiation is through both of PPARγ and GPR40 and GSK3β-dependent pathway. Mol Cell Endocrinol 2015 Sep 15;413:78-89
He P, Li Y, Ding X, Sun Q, Huang Y, Gu H, Ni X*. Expression of 15-Hydroxyprostaglandin Dehydrogenase in Human Chorion Is Associated with Peroxisome Proliferator-Activated Receptor Isoform Expression in Term Labor. Am J Pathol 2015 Jul;185(7):1981-1990
Liu W, Xu C, You X, Olson DM, Chemtob S, Gao L, Ni X*. Hydrogen Sulfide Delays LPS-Induced Preterm Birth in Mice via Anti-Inflammatory Pathways. PLoS One 2016;11:e0152838
Hu T, Wang G, Zhu Z, Huang Y, Gu H, Ni X*. Increased ADAM10 expression in preeclamptic placentas is associated with decreased expression of hydrogen sulfide production enzymes. Placenta 2015 Aug;36(8):947-950
Xu Y, Sheng H, Tang Z, Lu J, Ni X*. Inflammation and increased IDO in hippocampus contribute to depression-like behavior induced by estrogen deficiency. Behav Brain Res 2015 Jul 15;288:71-78
Xu C, You X, Liu W, Sun Q, Ding X, Huang Y, Ni X*. Prostaglandin F2α regulates the expression of uterine activation proteins via multiple signalling pathways. Reproduction 2015 Jan;149(1):139-146
Xu C, Liu W, You X, Leimert K, Popowycz K, Fang X, Wood SL, Slater DM, Sun Q, Gu H, Olson DM,Ni X*. PGF2α modulates the output of chemokines and pro-inflammatory cytokines in myometrial cells from term pregnant women through divergent signaling pathways. Mol Hum Reprod 2015 Jul;21(7):603-614
Wang L, Tang ZP, Zhao W, Cong BH, Lu JQ, Tang XL, Li XH, Zhu XY, Ni X*. MiR-22/Sp-1 Links Estrogens With the Up-Regulation of Cystathionine γ-Lyase in Myocardium, Which Contributes to Estrogenic Cardioprotection Against Oxidative Stress. Endocrinology 2015 Jun;156(6):2124-2137
Wang CN, Duan GL, Liu YJ, Yu Q, Tang XL, Zhao W, Li XH, Zhu XY*, Ni X*. Overproduction of nitric oxide by endothelial cells and macrophages contributes to mitochondrial oxidative stress in adrenocortical cells and adrenal insufficiency during endotoxemia. Free Radic Biol Med 2015 Jun;83:31-40
Xiao J, Zhu X, Kang B, Xu J, Wu L, Hong J, Zhang Y, Ni X*, Wang Z*. Hydrogen Sulfide Attenuates Myocardial Hypoxia-Reoxygenation Injury by Inhibiting Autophagy via mTOR Activation. Cell Physiol Biochem 2015;37(6):2444-2453
Kang B, Hong J, Xiao J, Zhu X, Ni X, Zhang Y, He B, Wang Z. Involvement of miR-1 in the protective effect of hydrogen sulfide against cardiomyocyte apoptosis induced by ischemia/reperfusion. Mol Biol Rep 2014 Oct;41(10):6845-6853
Tang Z, Wang Y, Zhu X, Ni X, Cong B, Lu J. Reduced expression of CRHR2 and Sp-1 in myocardium of ovariectomized rats is improved by exercise training. Gynecol Endocrinol 2015;31(9):742-746
Xiao J, Zhu X, Ji G, Yang Q, Kang B, Zhao J, Yao F, Wu L, Ni X*, Wang Z*. Ulinastatin protects cardiomyocytes against ischemia reperfusion injury by regulating autophagy through mTOR activation. Mol Med Rep 2014 Oct;10(4):1949-1953
Lu J, Xu Y, Hu W, Gao Y, Ni X, Sheng H, Liu Y. Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats. Neurosci Lett 2014 Jun 24;573:13-18
Wang CN, Liu YJ, Duan GL, Zhao W, Li XH, Zhu XY, Ni X*. CBS and CSE Are Critical for Maintenance of Mitochondrial Function and Glucocorticoid Production in Adrenal Cortex. Antioxid Redox Signal 2014;21(16):2192-2207
Cong B, Wang L, Zhu X, Li X, Liu B, Ni X*. SGK1 is involved in cardioprotection of urocortin-1 against hypoxia/reoxygenation in cardiomyocytes. Can J Cardiol 2014 Jun;30(6):687-695
Cong B, Xu Y, Sheng H, Zhu X, Wang L, Zhao W, Tang Z, Lu J, Ni X*. Cardioprotection of 17β-estradiol against hypoxia/reoxygenation in cardiomyocytes is partly through up-regulation of CRH receptor type 2. Mol Cell Endocrinol 2014 Jan 25;382(1):17-25
He P, Chen Z, Sun Q, Li Y, Gu H, Ni X*. Reduced expression of 11β-hydroxysteroid dehydrogenase type 2 in preeclamptic placentas is associated with decreased PPARγ but increased PPARα expression. Endocrinology 2014 Jan;155(1):299-309
Cong B, Zhu X, Cao B, Xiao J, Wang Z, Ni X*. Estrogens protect myocardium against ischemia/reperfusion insult by up-regulation of CRH receptor type 2 in female rats. Int J Cardiol 2013 Oct 12;168(5):4755-4760
Xu C, Long A, Fang X, Wood SL, Slater DM, Ni X*, Olson DM. Effects of PGF2α on the expression of uterine activation proteins in pregnant human myometrial cells from upper and lower segment. J Clin Endocrinol Metab 2013 Jul;98(7):2975-2983
Zhu X, Tang Z, Cong B, Du J, Wang C, Wang L, Ni X*, Lu J*. Estrogens increase cystathionine-γ-lyase expression and decrease inflammation and oxidative stress in the myocardium of ovariectomized rats. Menopause 2013 Oct;20(10):1084-1091
Li Y, He P, Sun Q, Liu J, Gao L, You X, Gu H, Ni X*. Reduced expression of 15-hydroxy prostaglandin dehydrogenase in chorion during labour is associated with decreased PRB whilst increased PRA and GR expression. Am J Pathol 2013; May;182(5):1585-1594
Liu W, Sheng H, Xu Y, Liu Y, Lu J, Ni X*. Swimming exercise ameliorates depression-like behavior in chronically stressed rats: relevant to proinflammatory cytokines and IDO activation. Behav Brain Res 2013;242:110-116
You X, Gao L, Liu J, Xu C, Liu C, Li Y, Hui N, Gu H, Ni X*. CRH activation of different signaling pathways results in differential calcium sgnaling in human pregnant myometrium before and during labor. J Clin Endocrinol Metab 2012;97(10):E1851-E1861
Gao L, Tao Y, Hu T, Liu W, Xu C, Liu J, You X, Gu H, Ni X*. Regulation of estradiol and progesterone production by CRH-R1 and -R2 is through divergent signaling pathways in cultured human placental trophoblasts. Endocrinology 2012;153(10):4918-4928
Sheng H, Xu Y, Chen Y, Zhang Y, Ni X*.Corticotropin-releasing hormone stimulates mitotic kinesin-like protein 1 expression via a PLC/PKC-dependent signaling pathway in hippocampal neurons. Mol Cell Endocrinol. 2012;362(1-2):157-164
Sheng H, Chen Y, Xu X, Xu Y, Zhang Y, Cheng H, Ni X*. CRH-R1 and CRH-R2 differentially modulate dendritic outgrowth of hippocampal neurons. Endocrine 2012;41(3):458-464
Gao L, Lv C, Xu C, Li Y, Cui X, Gu H, Ni X*. Differential regulation of glucose transporters mediated by CRH receptor Type 1 and Type 2 in human placental trophoblasts. Endocrinology 2012;153(3):1464-1471
Wang S, Zhu X, Cong B, You X, Wang Y, Wang WZ, Ni X*. Estrogenic action on arterial smooth muscle: Permissive for maintenance of CRHR2 expression. Endocrinology 2012;153(4):1915-1934
Zhang Y, Sheng H, Qi J, Ma B, Sun J, Li S, Ni X*. Glucocorticoid acts on a putative G-protein coupled receptor to rapidly regulate the activity of NMDA receptors in hippocampal neurons. Am J Physiol Endocrinol Metab 2012 Apr 1;302(7):E747-E758
Liu W, Xu Y, Lu J, Zhang Y, Sheng H, Ni X*. Swimming exercise ameliorates depression-like behaviors induced by prenatal exposure to glucocorticoids in rats. Neurosci Lett 2012;524(2):119-123
Xiao J, Zhu X, He B, Zhang Y, Kang B, Wang Z, Ni X*. MiR-204 regulates cardiomyocyte autophagy induced by ischemia-reperfusion through LC3-II. J Biomed Sci 2011 Jun 1;18:35
Li HJ, Wang LY, Qu HN, Yu LH, Burnstock G, Ni X, Xu M, Ma B. P2Y2 receptor-mediated modulation of estrogen-induced proliferation of breast cancer cells. Mol Cell Endocrinol 2011;338(1-2):28-37
Xu C, Gao L, You X, Dai L, Li Y, Gu H, Slater DM, Olson DM, Ni X*. CRH Acts on CRH-R1 and -R2 to Differentially Modulate the Expression of Large-Conductance Calcium-Activated Potassium Channels in Human Pregnant Myometrium. Endocrinology 2011;152:4406-4417
Xu C, You X, Gao L, Zhang L, Hu R, Hui N, Olson DM, Ni X*. Expression of ATP-sensitive potassium channels in human pregnant myometrium. Reprod Biol Endocrinol 2011;9:35
You XJ, Xu C, Lu J, Zhu XY, Gao L, Cui XR, Li Y, Gu H, Ni X*. Expression of cystathionine β-synthase and cystathionine γ-lyase in human pregnant myometrium and their roles in the control of uterine contractility. PLos one 2011;6(8):e23788
Ma B, Yu LH, Fan J, Cong B, He P, Ni X*, Burnstock G. Estrogen modulation of peripheral pain signal transduction: involvement of P2X(3) receptors. Purinergic Signal 2011;7(1):73-83
Hu R, Lu J, You X, Zhu X, Hui N, Ni X*. Hydrogen sulfide inhibits the spontaneous and oxytocin-induced contractility of human pregnant myometrium. Gynecol Endocrinol 2011;27(11):900-904
Liu S, Zhu X, Liu Y, Wang C, Wang S, Tang X, Ni X*. Endotoxin Tolerance of Adrenal Gland: Attenuation of Corticosterone Production in Response to Lipopolysaccharide and Adrenocorticotropin Hormone. Crit Care Med 2011 Mar;39(3):518-526
Xiao Jian, Zhu Xiaoyan, He Bin, Zhang Yufeng, Kang Bo, Wang Zhinong, Ni Xin*. MiR-204 regulate cardiomyocyte autophagy induced by hypoxia-reoxygenation through LC3-II. Int J Cardiol 2011;148(1):110-112
Peng JF, Wu ZT, Wang YK, Yuan WJ, Sun T, Ni X, Su DF, Wang W, Xu MJ, Wang WZ. GABAergic mechanism in the rostral ventrolateral medulla contributes to the hypotension of moxonidine. Cardiovasc Res 2011;89(2):473-481
Tang X, Zhu X, Liu S, Wang S, Ni X*. Isoflavones suppress cyclic adenosine 3',5'-monophosphate regulatory element-mediated transcription in osteoblastic cell line. J Nutr Biochem 2011 sep;22(9):865-873
Zhu XY, Gu H, Ni X*. Hydrogen sulfide in the endocrine and reproductive systems. Expert Rev Clin Pharmacol 2011;4(1):75-82
Zhu X, Liu X, He P, Cao B, LV Y; Zhang W; Ni X*. Metabolomics in serum of ovariectomised rats and those exposed to 17β-oestradiol and genistein. Gynecol Endocrinol 2010 Oct;26(10):760-767
Zhu XY, Liu SJ, Liu YJ, Wang S, Ni X* Glucocorticoids suppress cystathionine gamma-lyase expression and H2S production in lipopolysaccharide-treated macrophages. Cell Mol Life Sci 2010;67(7):1119-1132
Yang T, Mao Y, Liu S, Hou J, Cai Z, Hua J, Ni X, Deng X, Zhu X. Protective effects of the free radical scavenger edaravone on acute pancreatitis-associated lung injury. Eur J Pharmcol 2010, 630(1-3):152-157

Jinpeng Sun

Ph.D, Professor, Peking University
Young Qilu Scholar, Chair of the Department of Biochemistry and Molecular Biology, Shandong University School of Medicine
44 Wenhua Xi Road, Building 6, 6408; Jinan 250012; China
Phone (office): 086-531-88381910
Phone (cell): 15966613591
Email: sunjinpeng@sdu.edu.cn or sunjinpengsdu@126.com

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
1998 B.Sc. University of Science and Technology of China (USTC)
2001 M.S. University of Science and Technology of China (USTC)
2007 PhD. Albert Einstein College of Medicine, Bronx, New York. (USA)
2007-2011 Research Associate, Advisor: Robert Lefkowitz, James B. Duke Professor of Medicine and Biochemistry and Investigator, Howard Hughes Medical Institute (2012 Nobel Prize)

HONORS, PRIZES AND AWARDS
2014 The first prize of young scholar forum at the 11th Biochemistry and Molecualr Biology academic meeting at china
2015 Shandong Province college scientific award, first prize for the Pharmacological research by targeting GPCR and phosphatases

PERSONAL STATEMENT
Since starting my laboratory in 2011, I has focused on G protein coupled receptors, in particular, the molecular mechanism of biased signaling of GPCRs. Our first main research aspect are the working mechanism of GPCR. For arrestin mediated biased signaling, we have proposed a “flute model” to explain the arrestin mediated GPCR functions (Nature communications, 2015; Molecular Pharmacology, 2017; Recommended by Faculty 1000, Nature Chemical Biology 2018). We proposed that the 10 distinct phosphorylation interacting sites along the N-terminal of arrestin is the “phospho-code” reader of the arrestin, which recognized the information passed by GPCR, then translated to more then 1000 distinct functions. Our discovery can partially explain how limited effector proteins (16 G protein subtype and 4 arrestin subtype) can translate sophisticated information dictated from more than 800 GPCR to numerous cellular functions. We identified a new mechanism in activation of ion channel by GPCRs. A prototype thinking is that the ion channels are activated by GPCRs through either direct G protein interaction or second messengers downstream of G protein activation. We identified that arrestin can mediated AT1R/TRPC3 or M3R/TRPC3 coupling by forming a complex of AT1R/β-arrestin-1/PLCγ/TRPC3 or M3R//β-arrestin-1/TRPC3 (Nature communications 2017, Nature communications 2018). We also identified that orphan receptor GPR64 forms complex with β-arrestin-1 and CFTR at apical membrane of efferent ductules to regulate the salt/water metabolism (eLife 2018, Faculty 1000 recommendation). These work provided new mechanisms for GPCR activated ion channel, which may be relevant to many physiological or pathological processes. Our second research aspect is the physiological and pathological functions of GPCRs. We have elucidated how CCK1R different biased signaling and β adrenergic biased signaling regulated different pancreatic islet function and homeostasis. We also identified that short term activation of β2AR signaling improved learning and memory by increased lactate metabolism and astrocyte-neuron lactate shuttle (ANLS), whereas long term stress or activation of β2AR signaling has harmful effect on learning and memory through a desensitization mechanism.

SELECTED PUBLICATIONS (# correspondence author; * first author and co-autors)

Gong Q*, Qin W*, Xiao P*, Wu X, Li L#, Zhang G, Zhang R, Sun J#, Yao SQ#, Huang W#. Internal Standard Fluorogenic Probe Based on Vibration-induced Emission for Visualizing PTP1B in Living Cells. Chem Commun (Camb) 2019 Dec 17;56(1):58-61
Huang SM#, Yang F, Cai BY, He QT, Liu Q, Qu CX, Han MJ, Kong W, Jia YL, Li F, Yu X, Sun JP#, Wang J#. A Genetically Encoded Fluorescent Amino Acid for Monitoring Protein Interactions through FRET. Anal Chem 2019 Dec 3;91(23):14936-14942
Park JY, Qu CX, Li RR, Yang F, Yu X, Tian ZM, Shen YM, Cai BY, Yun Y, Sun JP#, Chung KY#. Structural Mechanism of the Arrestin-3/JNK3 Interaction. Structure 2019 Jul 2;27(7):1162-1170
Li K, Hou X, Li R, Bi W, Yang F, Chen X, Xiao P, Liu T, Lu T, Zhou Y, Tian Z, Shen Y, Zhang Y, Wang J, Fang H, Sun JP#, Yu X#. Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22. J Biol Chem 2019 May 24;294(21):8653-8663
Rostaminasab Dolatabad M, Guo LL, Xiao P, Zhu Z, He QT, Yang DX, Qu CX, Guo SC, Fu XL, Li RR, Ge L, Hu KJ, Hong-da L, Shen YM, Yu X, Sun JP#*, Zhang PJ#. Crystal structure and catalytic activity of the PPM1K N94K mutant. J Neurochem 2019 Feb;148(4):550-560
Hou X, Rooklin D, Yang D, Liang X, Li K, Lu J, Wang C, Xiao P, Zhang Y, Sun JP, Fang H Computational Strategy for Bound State Structure Prediction in Structure-Based Virtual Screening: A Case Study of Protein Tyrosine Phosphatase Receptor Type O Inhibitors. J Chem Inf Model 2018 Nov 26;58(11):2331-2342
Yang D, Xiao P, Li Q, Fu X, Pan C, Lu D, Wen S, Xia W, He D, Li H, Fang H, Shen Y, Xu Z, Lin A, Yu X, Wu JW#, Sun J#. Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot autoinhibition and activation. J Biol Chem 2018 Oct 19;293(42):16226-16241
Yang F, Xiao P, Qu CX, Liu Q, Wang LY, Liu ZX, He QT, Liu C, Xu JY, Li RR, Li MJ, Li Q, Guo XZ, Yang ZY, He DF, Yi F, Ruan K, Shen YM, Yu X, Sun JP#, Wang JY#. Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin. Nat Chem Biol 2018 Sep;14(9):876-886
Li N, Yang Z, Li Q, Yu Z, Chen X, Li JC, Li B, Ning SL, Cui M, Sun JP, Yu X. Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents. Cell Death Dis 2018 Jun 7;9(6):682
Nair A, Chung H, Sun T, Tyagi S, Dobrolecki LE, Rocio DV, Kurley SJ, Orellana M, Renwick A, Henke DM, Katsonis P, Chan DW, Li H, Mao S, Petrovic I, Creighton CJ, Gutierrez C, Dubrulle J, Stossi F, Tyner JW, Lichtarge O, Lin CY, Scott KL, Hilsenbeck SG, Sun J, Yu X, Osborne C. K, Schiff R, Christensen JG, Shields DJ, Rimawi MF, Ellis MJ, Shaw CA, Lewis MT, Westbrook TF. Targeting receptors that share the feedback inhibitor PTPN12 leads to broad spectrum therapeutic suppression of triple-negative breast cancer. Nature Medicine 2018 May;24(4):505-551
Gpr97 Exacerbates AKI by Mediating Sema3A Signaling. Fang W, Wang Z, Li Q, Wang X, Zhang Y, Sun Y, Tang W, Ma C, Sun J, Li N, Yi F. J Am Soc Nephrol 2018 May;29(5):1475-1489
Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D#, Yu X#, Sun JP#. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility. Elife 2018 Feb 2;7:e33432
Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, Zhu M, Yin H, Wang X, Fu Y, Yu F, Wang X, Fang X, Sun JP#, Kong Wei#. Direct Interaction and Dual Roles of Homocysteine on the Angiotensin II Type 1 Receptor in the Aggravation of Vascular Injury. Nat Commun 2018 Jan 2;9(1)
Li H, Yang D, Ning S, Xu Y, Yang F, Yin R, Feng T, Han S, Guo L, Zhang P, Qu W, Guo R, Song C, Xiao P, Zhou C, Xu Z, Sun JP#, Yu X#. Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways. FASEB J 2018 Jan;32(1):73-82
Xu H, Li Q, Liu J, Zhu J, Li L, Wang Z, Zhang Y, Sun Y, Sun J, Wang R, Yi F. β-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1/β-catenin signaling in mice. J Mol Med (Berl) 2018 Jan;96(1):97-109
Xiao K, Sun J. Elucidating structural and molecular mechanisms of β-arrestin-biased agonism at GPCRs via MS-based proteomics. Cell Signal 2018 Jan;41:56-64
Yang J, Yin HS, Cao YJ, Jiang ZA, Li YJ, Song MC, Wang YF, Wang ZH, Yang R, Jiang YF, Sun JP, Liu BY, Wang C. Arctigenin Attenuates Ischemia/Reperfusion Induced Ventricular Arrhythmias by Decreasing Oxidative Stress in Rats. Cell Physiol Biochem 2018;49(2):728-742
Zhang H, Xiao P, Wong YT, Shen W, Chhabra M, Peltier R, Jiang Y, He Y, He J, Tan Y, Xie Y, Ho D, Lam YW#, Sun J#, Sun H#.Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues. Biomaterials 2017 Sep;140:220-229
Yang Z, Yang F, Zhang D, Liu Z, Lin A, Liu C, Xiao P, Yu X, Sun JP#. Phosphorylation of G protein-coupled receptors: from the barcode hypothesis to the flute model. Mol Pharmacol 2017 Sep;92(3):201-210
Li Q, Cui M, Yang F, Li N, Jiang B, Yu Z, Zhang D, Wang Y, Zhu X, Hu H, Li PS, Ning SL, Wang S, Qi H, Song H, He D, Li A, Zhang J, Liu F, Zhao J, Gao L, Yi F, Xue T, Sun JP, Gong Y#, Yu X#. (2017) A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions. J Clin Invest 2017 Jun 30;127(7):2631-2646
Dong JH, Wang YJ, Cui M, Wang XJ, Zheng WS, Ma ML, He DF, Hu QX, Zhang DL, Ning SL, Liu CH, Wang C, Wang Y, Li XY, Lin A, Kahsai A, Cahill III T, Chen ZY, Yu X, Sun JP#. Adaptive activation of a stress response pathway improves learning and memory through Gs and β-arrestin-1 regulated lactate metabolism. Biol Psychiatry 2017 Apr 15;81(8):654-670
Cahill TJ, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ. Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. Proc Natl Acad Sci U S A 2017 Mar 7;114(10):2562-2567
Liu CH, Gong Z, Liang Zl, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Xiao KH, Zhou Z, Yu X, Sun JP#. Arrestin biased GPCR agonism induces acute catecholamine secretion through TRPC3 coupling. Nat Commun 2017 Feb 9;8:14335
Ge L, Li KS, Li MM, Xiao P, Hou XB, Chen X, Liu HD, Lin A, Yu X, Ren GJ, Fang H, Sun JP#. Identification of a benzo imidazol thiazol derivative as the specific irreversible inhibitor of protein tyrosine phosphatase. Bioorg Med Chem Lett 2016 Oct 1;26(19):4795-4798
Sun J#, Zhang D, Wang Y, Lin H, Yu X, Xu Z. The Role of G Protein-coupled Receptors in Cochlear Planar Cell Polarity. Int J Biochem Cell Biol 2016 Aug;77(Pt B):220-225
Li H, Yang F, Liu CH, Xiao P, Xu YF, Liang ZL, Liu C, Wang HM, Wang WJ, Zheng WS, Zhang W, Ma XY, He DF, Song XY, Cui FA, Xu ZG, Yi F, Sun JP#, Yu X#. Crystal structure and substrate specificity of PTPN12. Cell Reports 2016 May 10;15(6):1345-358
J Liu, QX Li, XJ Wang, C Zhang, YQ Duan, ZY Wang, Y Zhang, X Yu, NJ Li, JP Sun#，F Yi#. β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy. Cell Death Dis 2016 Apr 7;7(4):e2183
Li A, Yang D, Zhu M, Tsai KC, Xiao KH, Yu X, Sun J#, Du L#. Discovery of novel FFA4 (GPR120) receptor agonists with β-arrestin2-biased characteristics. Future Med Chem 2015 Dec;7(18):2429-2437
Li KS, Xiao P, Zhang DL, Hou XB, Ge L, Yang DX, Liu HD, He DF, Chen X, Han KR, Song XY, Yu X, Fang H, Sun JP#. Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot. ChemMedChem 2015 Dec;10(12):1980-1987
Ning SL, Zheng WS, Su J, Liang N, Dong JH, Zhang ZK, Cui M, Hu QX, Chen CC, Liu CH, Wang C, Pang Q, Chen YX, Yu X#, Sun JP#. Different downstream signaling of CCKAR regulates distinct functions of CCK in pancreatic β cells. Br J Pharmacol 2015 Nov;172(21):5050-5067
Yang F, Yu X, Liu C, Qu CX, Gong Z, Liu HD, Li FH, Wang HM, He DF, Yi F, Song C, Tian CL, Xiao KH, Wang JY#, Sun JP#. Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR. Nat Commun 2015 Sep 8;6:8202
Hou X, Li K, Yu X, Sun JP, Fang H. Protein Flexibility in Docking-based Virtual Screening: Discovery of Novel Lymphoid-specific Tyrosine Phosphatase Inhibitors using Multiple Crystal Structures. J Chem Inf Model 2015 Sep 28;55(9):1973-1983
Liu HD, Wang WB, Xu ZG, Liu CH, He DF, Du LP, Li MY, Yu X, Sun JP#. G protein-coupled receptor 120：A hot target for the development of anti-diabetic therapies. Eur J Pharmacol 2015 Sep 15;763(Pt B):160-168
Pan C, Tang JY, Xu YF, Xiao P, Liu HD, Wang HA, Wang WB, Meng FG, Yu X#, Sun JP#. The catalytic role of the M2 metal ion in PP2Cα. Sci Rep 2015 Feb 24;5:8560
Wang XJ, Zhang DL, Xu ZG, Ma MM, Wang WB, Han XL, Huo YQ, Yu X#, Sun JP#. Understanding CELSRs - Cadherin EGF LAG seven-pass G-type receptors. J Neurochem 2014 Dec;131(6):699-711
Xiao P, Wang X, Wang HM, Fu XL, Cui FA, Yu X, Wen SS, Bi WX#, Sun JP#. The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop. Int J Biochem Cell Biol 2014 Dec;57:84-95
Hou XB, Li R, Li KS, Yu X, Sun JP#, Fang H#. Fast Identification of Novel Lymphoid Tyrosine Phosphatase Inhibitors Using Target-Ligand Interaction-Based Virtual Screening. J Med Chem 2014 Nov 26;57(22):9309-9322
Wang HM, Xu YF, Ning SL, Yang DX, Li Y, Du YJ, Yang F, Zhang Y, Liang N, Yao W, Zhang LL, Gu LC, Gao CJ, Pang Q, Chen YX, Xiao KH, Yu X#, Sun JP#. The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Cell Res 2014 Sep;24(9):1067-1090
Wang HM, Dong JH, Li Q, Hu Q, Ning S, Zheng W, Chen TS, Xie X, Sun JP#, Yu X#. A stress response pathway upregulates somatostatin level and transcription in pancreatic delta-cells through Gs and β-arrestin1. Diabetologia 2014 Sep;57(9):1899-1910
Hu QX, Dong JH, Du H, Zhang DL, Ren HZ, Ma ML, Ci Y, Zhao TC, Yin XL, Yu X, Xut T, Xu ZG#, Sun JP#. Constitutive Gαi coupling activity of VLGR1 and its regulation by PDZD7. J Biol Chem 2014 Aug 29;289(35):24215-24225
Kahsai AW, Rajagopal S, Sun J, Xiao K. Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry (CDSiL-MS). Nature protocols 2014 Jun;9(6):1301-1319
Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Thomsen AR, Zhu X, Kleist A, Costa T, Lefkowitz RJ. Divergent Transducer-Specific Molecular Efficacies Generate Biased Agonism At A G Protein-Coupled Receptor (GPCR). J Biol Chem 2014 May 16;289(20):14211-14224
Kotula JW*, Sun J* (co-first author), Li M, Pratico ED, Fereshteh MP, Ahrens DP, Sullenger BA, Kovacs JJ. Targeted Disruption of β-Arrestin 2-Mediated Signaling Pathways by Aptamer Chimeras Leads to Inhibition of Leukemic Cell Growth. PLoS One 2014 Apr 15;9(4):e93441
Li R, Xie DD, Dong JH, Li H, Li KS, Su J, Chen LZ, Xu YF, Wang HM, Gong Z, Cui GY, Yu X, Wang K, Yao W, Xin T, Li MY, Xiao KH, An XF, Huo YQ, Xu ZG, Sun JP#, Pang Q#. Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase (STEP). J Neurochem 2014 Jan;128(2):315-329
Pan C, Liu HD, Gong Z, Yu X, Hou XB, Xie DD, Zhu XB, Li HW, Tang JY, Xu YF, Yu JQ, Zhang LY, Fang H, Xiao KH, Chen YG, Wang JY, Pang Q, Chen W#, Sun JP#. Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site. Sci Rep 2013;3:2333
Wang K, Zhu D, Yu X, Sun J, Yao W. Differences in the H2S-induced quantal release of catecholamine in adrenal chromaffin cells of neonatal and adult rats. Toxicology 2013 Oct 4;312C:12-17
Jiang H, Sun J, Xu Q, Liu Y, Wei J, Young CY, Yuan H, Lou H. Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells. Cell Death Dis 2013 Aug 8;4:e761
Li R, Gong Z, Pan C, Xie DD, Tang JY, Cui M, Xu YF, Yao W, Pang Q, Xu ZG, Li MY, Yu X#, Sun JP#. PPM1A functions as an ERK phosphatase. FEBS J 2013 Jun;280(11):2700-2711
Sun JP#*, Li R, Ren HZ, Xu AT, Yu X, Xu ZG#. The very large G protein coupled receptor (Vlgr1) in hair cells. J Mol Neurosci 2013 May;50(1):204-214
Li F, Shi P, Li J, Yang F, Wang T, Zhang W, Gao F, Ding W, Li D, Li J, Xiong Y, Sun J, Gong W, Tian C, Wang J. A Genetically Encoded (19) F NMR Probe for Tyrosine Phosphorylation. Angew Chem Int Ed Engl 2013 Apr 2;52(14):3958-3962
Zhu D, Yu X, Sun J, Li J, Ma X, Yao W. H(2)S induces catecholamine secretion in rat adrenal chromaffin cells. Toxicology 2012 Dec 8;302(1):40-43
Dong JH, Chen X, Cui M, Yu X, Pang Q, Sun JP#. Beta2- Adrenergic Receptor and Astrocyte Glucose Metabolism. J Mol Neurosci 2012 Oct;48(2):456-463
Dou HQ, Xu YF, Sun JP, Shang S, Guo S,Zheng LH, Chen CC, Bruce IC, Zhou Z, Yu X. Thiopental-induced insulin secretion via activation of IP3-sensitive calcium stores in rat pancreatic beta cells. Am J Physiol Cell Physiol 2012 Mar 1;302(5):C796-803
Xiao P, Yang L, Zhang C, Wang JY, Sun JP#. Discovery of GPCR superfamily and elucidation its working mechanisms and structures, to decode 2012 Nobel Prize in Chemistry. PIBB 2012;39(11):1050-1060
Liu J, Chen M, Yang F, Li R, Shi XR, Wang HM, Liu QJ, Yao W, Sun JP, Pang Q, Yu X. Biochemical and functional studies of Lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W. PLoS ONE 2012;7(8):e43631
Yu X, Chen M, Zhang S, Yu Z, Sun JP, Wang L, Liu S, Imasaki T, Takagi Y, Zhang ZY. Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of SKAP-HOM as a Lyp substrate. J Biol Chem 2011 Sep 2;286(35):30526-30534
Kahsai AW, Xiao K, Rajagopal S, Ahn S, Shukla AK, Sun J, Oas TG, Lefkowitz RJ Multiple ligand-specific Conformations of the β2-Adrenergic Receptor. Nature Chemical Biology 2011 Aug 21;7(10):692-700
Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK,Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma'ayan A, Gygi SP, Lefkowitz RJ. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci USA 2010 Aug;107(34):15299-15304
Chen M, Sun JP, LIU J, Yu X. Research progress of several protein tyrosine phosphatases. Acta Physiologica Sinica 2010 Apr;25:163-170

Zhongmin Tian

Ph.D, Professor, School of Life Science and Technology, Xian Jiaotong University
Room 523, No.28 Xianning West Road, Xi'an School of Life Science and Technology, Xi'an Jiaotong University
Phone: 029-82663286-92
Email: zmtian@mail.xjtu.edu.cn
Website: http://gr.xjtu.edu.cn/web/zmtian

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2010-present: Professor, Schoole of life science and technology, Xi'an Jiaotong University
2004-2010: Associate professor, Schoole of life science and technology, Xi'an Jiaotong University
2005-2008: Post doctotor, Physiology, Medical college of Wisconsin
2008-2009: Visitor scholar, Physiology, Medical college of Wisconsin
2004: Doctor, Xi'an Jiaotong University, Biomedical Engineering
2000: Master, Northwest University, Biology

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS
Member of Kidney Committee of Chinese Physiological Society
Member and vice-chairman of the third ultrasound bio-effects committee of the China Biomedical Engineering Committee
Journal manuscript reviewers: Analytica Chimica Acta，Physiol Genomics，Current Pharmaceutical Design, Current Drug Delivery, Analytical Methods, scientific report, Journal of Diabetes Research, BMC Cardiovascular Disorders, Life Sciences, Pharmaceutics

SELECTED PUBLICATIONS

Xuewei Zheng, Meng Chen, Xiaoxue Li, Pengfei Yang, Xinrui Zhao, Yanan Ouyang, Zhe Yang, Mingyu Liang, Entai Hou*, Zhongmin Tian*. Insufficient fumarase contributes to hypertension by an imbalance of redox metabolism in Dahl salt-sensitive rats. Hypertens Res. 2019 Nov;42(11):1672-1682
Xuewei Zheng, Xiaoxue Li, Meng Chen, Pengfei Yang, Xinrui Zhao, Li Zeng, Yanan OuYang, Zhe Yang, Zhongmin Tian*. The protective role of hawthorn fruit extract against high salt-induced hypertension in Dahl salt-sensitive rats: impact on oxidative stress and metabolic patterns. Food & Function. 2019;10(2):849-858
Yuan Cheng, Haiying Song, Xiaoqing Pan, Hong Xue, Yifei Wan, Tao Wang, Zhongmin Tian, Entai Hou, Ian R Lanza, Pengyuan Liu, Yong Liu, Purushottam W Laud, Kristie Usa, Yongcheng He, Mingyu Liang. Urinary Metabolites Associated with Blood Pressure on a Low- or High-Sodium Diet. Theranostics. 2018;8(6):1468-1480
Hou E, Li X, Liu Z, Zhang F, Tian Z. Combined metabolomic and correlation networks analyses reveal fumarase insufficiency altered amino acid metabolism. Biomed Chromatogr. 2018 Apr;32(4):e4133
Usa K, Liu Y, Geurts AM, Cheng Y, Lazar J, Baker MA, Grzybowski M, He Y, Tian Z*, Liang M*. Elevation of fumarase attenuates hypertension and can result from a nonsynonymous sequence variation or increased expression depending on rat strain. Physiol Genomics. 2017 Sep 1;49(9):496-504
Zhengjun Wang, Qiong Sun, Na Sun, Mingyu Liang, Zhongmin Tian*. Mitochondrial dysfunction and altered renal metabolism in Dahl salt-sensitive rats. Kidney Blood Press Res. 2017;42(3):587-597
Entai Hou, Na Sun, Fuchang Zhang, Chenyang Zhao, Kristie Usa, Mingyu Liang*, Zhongmin Tian*. Malate and Aspartate Increase L-arginine and Nitric Oxide and Attenuate Salt-Sensitive Hypertension. Cell Rep. 2017 May 23;19(8):1631-1639
Le Wang, Entai Hou, Lijun Wang, Yanjun Wang, Lingjian Yang, Xiaohui Zheng, Guangqi Xie, Qiong Sun, Mingyu Liang, Zhongmin Tian*. Reconstruction and analysis of correlation networks based on GC–MS metabolomics data for young hypertensive men. Anal Chim Acta. 2015 Jan 7;854:95-105
Liqing He, Xiaochang Xue, Zhengjun Wang, Entai Hou, Yong Liu, Mingyu Liang, Yingqi Zhang, Zhongmin Tian*. Transcriptional regulation of heterogeneous nuclear ribonucleoprotein K gene expression. Biochimie. 2015 Feb;109:27-35
Le Wang, Entai Hou, Liqing He, Zhengjun Wang, Na Sun, Lan Chen, Pu Jia, Xiaohui Zheng, Mingyu Liang, Zhongmin Tian*. Analysis of metabolites in plasma reveals distinct metabolic features between Dahl salt-sensitive rats and consomic SS.13BN rats. Biochem Biophys Res Commun. 2014 Jul 18;450(1):863-869
Xiaofeng He, Yong Liu, Kristie Usa, Zhongmin Tian, Allen W Cowley Jr, Mingyu Liang. Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats. Am J Physiol Renal Physiol. 2014 May 15;306(10):F1190-F1197
Alison J Kriegel, Yi Fang, Yong Liu, Zhongmin Tian, Domagoj Mladinov, Isaac R Matus, Xiaoqiang Ding, Andrew S Greene, Mingyu Liang. MicroRNA-Target Pairs in Human Renal Epithelial Cells treated with Transforming Growth Factor β1: A Novel Role of miR-382. Nucleic Acids Res. 2010 Dec;38(22):8338-8347

Haibing Wang

Min River Distinguish Professor, Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University
Address: Room 219, Chengyi Building, Xiamen University, Xiang’an South Road, Xiamen 361102, Fujian, China
Phone: (86) 592-2880501 (office)
Email: haibin.wang@vip.163.com

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2016-Present: Director of Fujian Provincial Key Laboratory of Reproductive Health Research, School of Medicine, Xiamen University
2008‐2016: Principal Investigator, State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
2006-2008: Assistant Professor, Pediatrics, Vanderbilt University Medical Center
2004-2006: Research Assistant Professor, Pediatrics, Vanderbilt University Medical Center
2002-2004: Lalor Foundation Postdoctoral Fellow, Vanderbilt University Medical Center
2001-2002: Postdoctoral Fellow, University of Kansas Medical Center
1992-1996: B.Sc. (Animal Physiology & Biochemistry) China Agricultural University, China
1996-2001: Ph.D. (Reproductive Biology) China Agricultural University, China
2000-2001: Short-term exchange student (Reproductive Biology) Tokyo University of Agriculture and Technology, Japan

HONORS, PRIZES AND AWARDS
Youth Science and Technology Innovation Leader of Ministry of Science and Technology
China Youth Science and Technology Award (2013)
Leading Talents of Fujian University
The first Outstanding Young Person Award in Xiamen Yong Scientist of Chinese Academy of Science
Zhuliyuehua excellent teacher award of Chinese Academy of Science (2013)
Recipient of "National Outstanding Youth Foundation" (2008)

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS
Associate Editor of Biol Reprod, Editor Board member of Am J Reprod Immunol, J Reprod Immunol, PLoS ONE, Scientific Reports, Development & Reproduction, Reproductive Medicine and Biology, Animal Models and Experimental Medicine. ad hoc reviewer for Nat Med, JCI, JAMA, PLoS Genetics, J Biol Chem, Mol Endocrinol, Endocrinology, Reproduction, Hum Reprod, Mol Hum Reprod, Fertil Steril, BMC Genomics and Placenta

SELECTED PUBLICATIONS

He B, Zhang H, Wang J, Liu M, Sun Y, C Guo, Lu J, Wang H*, Kong S*. Blastocyst activation engenders transcriptome reprogram affecting X-chromosome reactivation and inflammatory trigger of implantation. Proc Natl Acad Sci U S A. 2019;116(33):16621-16630
Xin Q, Kong S, Yan J, Qiu J, He B, Zhou C, Ni Z, Bao H, Huang L, Lu J, Xia G, Liu X*, Chen Z*, Wang C*, Wang H*. Polycomb subunit BMI1 determines uterine progesterone responsiveness essential for normal embryo implantation. J Clin Invest. 2018 Jan 2;128(1):175-189
Cui T, He B, Kong S, Zhou C, Zhang H, Ni Z, Bao H, Qiu J, Xin Q, Reinberg D, Lydon JP, Lu J*, Wang H*. PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice. Cell Death Differ. 2017 Dec;24(12):2013-2021
Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z*, Wang C*, Wang H*. Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 2017;114(18):4816-4821
Tu Z, Wang Q, Cui T, Wang J, Ran H, Bao H, Lu J, Wang B, Lydon JP, DeMayo F, Zhang S, Kong S*, Wu X*, Wang H*. Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice. Cell Death Differ. 2016;23(1):169-181
Liao Y, Jiang Y, He H, Ni H, Tu Z, Zhang S, Wang B, Lou J, Quan S*, Wang H*. NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization. Hum Reprod. 2015;30(7):1665-1676
Tang X, Chen Y, Ran H, Jiang Y, He B, Wang B, Kong S*, Wang H*. Systemic morphine treatment derails normal uterine receptivity, leading to embryo implantation failure in mice. Biol Reprod. 2015 May;92(5):118
Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang HM, Wang YL, Li B, Chen Q*, Duan E*, Wang H*. Uterine Rbpj is required for embryo-uterine orientation and decidual remodeling via Notch pathway- independent and -dependent mechanisms. Cell Res. 2014;24(8):925-942
Fu Z, Wang B, Wang S, Wu W, Wang Q, Chen Y, Kong S, Lu J, Tang Z, Ran H, Tu Z, He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang YL, Li L, Wang F*, Gao S*, Wang H*. Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice. Biol Reprod. 2014;90(3):52
Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W, Wang B, Wang HM, Wang Y, van Es JH, Clevers H, Leone G, Cross JC*, Wang H*. A positive feedback loop involving gcm1 and fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 2013;11(4):e1001536

Yun Wang

Professor Yun Wang graduated from Jiangxi Medical College with BA of Medicine in 1989, and received her M.S in Physiology in 1992 and PhD in Neurophysiology in 1996 from Beijing Medical University (which merged with Peking University in year 2000 with the new name “Peking University Health Science Centre”). From 2000-2002, she worked in NCI, NIH as a visiting scientist. She became a professor and vice director of Department of Neurobiology (since 2004) & Neuroscience Research Institute (since 2009), associate dean of School of Basic Medical Sciences (Since 2013), Peking University Health Science Center. Professor Wang is President (since 2018) of Chinese Association for Physiological Sciences (CAPS).

Professor Wang's major research interests include signal transduction (especially protein kinases) of pain and pain modution, and molecular mechanisms of neuronal develepment, injury and repair. She has received more than 20 national research grants to support her research and published more than 80 scientific papers, among them 60 papers have been published in peered review journals, such as Nature Commun, Cell Rep, J Neurosci etc. Furthermore, she has been the recipient of several awards and honors during her career such as “Distinguished Young Investigator Award” (2010) from the National Natural Science Foundation of China; “The Teaching and Research Award Program for Outstanding Young Teachers in Higher Education Institutions” (2001) from Ministry of Education of China, “Hsiang-Tung Chang Outstanding Young Scientist Prize” from Hsiang-Tung Chang Foundation (2013).

SELECTED PUBLICATIONS

Liu J*, Du J*, Wang YCA. CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2. Sci Signal. 2019 Jun 11;12(585):eaaw2040
Hu F*, Liu HC*, Su DQ*, Chen HJ, Chan SO, Wang YCA, Wang JCA. Nogo-A promotes inflammatory heat hyperalgesia by maintaining TRPV-1 function in the rat dorsal root ganglion neuron. FASEB J. 2019 Jan;33(1):668-682
Tian NX*, Xu Y*, Yang JY, Li L, Sun XH, Wang YCA, Zhang YCA. KChIP3 N-terminal 31-50 fragment mediates its association with TRPV1 and alleviates inflammatory hyperalgesia in rats. J Neurosci. 2018 Feb 14;38(7):1756-1773
Cen C*, Luo LD*, Li WQ, Li G, Tian NX, Zheng G, Yin DM, Yimin Zou, Wang YCA. PKD1 promotes functional synapse formation coordinated with N-cadherin in hippocampus. J Neurosci. 2018 Jan 3;38(1):183-199
Huang M, Cheng G, Tan H, Qin R, Zou Y, Wang YCA, Zhang YCA. Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors. Exp Neurol. 2017 Sep;295:66-76
Qin R*, Cao S*, Lyu T, Qi C, Zhang W, Wang YCA. CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy. Cell Rep. 2017 Jan 10;18(2):380-390
Zhang C*, Lu J*, Liu B, Cui Q, Wang YCA. Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease. Aging (Albany NY). 2016 Feb;8(2):272-290
Liu J*, Du J*, Yang Y, Wang YCA. Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia. Exp Neurol. 2015 Nov;273:253-262
Wang GQ*, Cen C*, Cao S*, Li C*, Wang N, Zhou Z, Liu XM, Xu Y, Tian NX, Zhang Y, Wang J, Wang LPCA, Wang YCA. Deactivation of excitatory neurons in the contralateral prelimbic cortex via Cdk5 promotes pain sensation and anxiety. Nat Commun. 2015 Jul 16;6:7660
Li Y*, Hu F*, Chen HJ*, Du YJ, Xie ZY, Zhang Y, Wang JCA, Wang YCA. LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats. Sci Signal. 2014 Jun 24;7(331):ra61
Wang N*, Su P*, Zhang Y*, Lu J*, Xing BM, Kang K, Li WQ, Wang YCA. Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses. Neuropsychopharmacol. 2014 Apr;39(5):1290-1301
Qi C*, Liu SM*, Qin R*, Zhang Y, Wang GQ, Shang, YF, Wang YCA, Liang JCA. Coordinated Regulation of Dendrite Arborization by Epigenetic Factors CDYL and EZH2. J Neurosci. 2014 Mar 26;34(13):4494-508

Guangyin Xu

Dr. Xu is a principle investigator, full professor and Associated Director of the Institute of Neuroscience at Soochow University. He has been long interested in the field of Neuroscience and Pain Medicine. Dr. Xu had his postdoctoral training program and had been appointed as an Assistant Professor (Tenured Track) in the Department of Internal Medicine of the University of Texas Medical Branch of the United States of American since 1998. He was awarded a number of research funds, including those from NIH. His main research findings have been published in PNAS, Journal of Neuroscience, Gastroenterology, GUT, Pain, Diabetes, etc. Dr. Xu was Associate Editor of Neuroscience Bulletin, Editorial Board Member of Biomed Research International, Am J of Psychiatry and Neuroscience, Pain and Itch, Channels, etc and a peer-reviewer of a number of international journals such as GUT, AJP-GI, Mol Pain, Mol Brain, etc. He returned to China in 2010 and was appointed as “Jiangsu Distinguished Professor” in 2010 and “Double Innovation Talent Award” in 2013 and the leader of the “Jiangsu Double talents team” in 2015. His research has been funded by the key project from the NSFC of China. He has published more than 80 peer-reviewed papers in top-tier international journals.

SELECTED PUBLICATIONS

Zhang Y, Song J, He XZ, Xiong J, Xue R, Ge JH, Lu SY, Hu D, Zhang GX, Xu GY*, Wang LH*. Quantitative Determination of Glymphatic Flow Using Spectrophotofluorometry. Neurosci Bull. 2020 Jul 25
Zhang PA, Sun Q, Li YC, Weng RX, Wu R, Zhang HH, Xu GY*. Overexpression of Purinergic P2X4 Receptors in Hippocampus Rescues Memory Impairment in Rats with Type 2 Diabetes. Neurosci Bull. 2020 Jul;36(7):719-732
Li X, Xu YC, Tian YQ, Zhang PA, Hu SF, Wang LH, Jiang XH*, Xu GY*. Downregulation of GRK6 in arcuate nucleus promotes chronic visceral hypersensitivity via NF-κB upregulation in adult rats with neonatal maternal deprivation. Mol Pain. 2020 Jan-Dec;16:1744806920930858
Weng RX, Chen W, Tang JN, Sun Q, Li M, Xu X, Zhang PA, Zhang Y, Hu CY*, Xu GY*. Targeting spinal TRAF6 expression attenuates chronic visceral pain in adult rats with neonatal colonic inflammation. Mol Pain. 2020 Jan-Dec;16:1744806920918059
Long HC, Wu R, Liu CF, Xiong FL, Xu Z, He D, Zhang YF, Shao B, Zhang PA, Xu GY*, Chu L*. MiR-125a-5p Regulates Vitamin D Receptor Expression in a Mouse Model of Experimental Autoimmune Encephalomyelitis. Neurosci Bull. 2020 Feb;36(2):110-120
Zhang C, Lin J, Wei F, Song J, Chen W, Shan L, Xue R, Wang G, Tao J, Zhang G, Xu GY*, Wang L*. Characterizing the glymphatic influx by utilizing intracisternal infusion of fluorescently conjugated cadaverine. Life Sci. 2018 May 15;201:150-160
Honghong Zhang, Ji Hu*, Youlang Zhou, Xin Qin, Zhenyuan Song, Panpan Yang, Shufen Hu, Xinghong Jiang, Guangyin Xu*. Promoted interaction of nuclear factor-κB with demethylated purinergic P2X3 receptor gene contributes to neuropathic pain in rats with diabetes. Diabetes. 2015 Dec;64(12):4272-4284
Honghong Zhang, Ji Hu, Youlang Zhou, Shufen Hu, Yongmeng Wang, Wei Chen, Ying Xiao, Liyen Mae Huang, Xinghong Jiang, Guangyin Xu*. Promoted interaction of nuclear factor-κB with demethylated cystathionine-β-synthetase gene contributes to gastric hypersensitivity in diabetic rats. J Neurosci. 2013 May 22;33(21):9028-9038

Bin Yang

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2018-present: Honorary Professor, Cardiovascular Sciences, University of Leicester; Senior Research Scientist, University Hospitals of Leicester
2015-2018: Honorary Reader, Infection, Immunity and Inflammation, University of Leicester
2012-2015: Honorary Senior Lecturer, Infection, Immunity and Inflammation, University of Leicester
2008-2012: Honorary Lecturer, Infection, Immunity and Inflammation, University of Leicester; Senior Research Scientist, University Hospitals of Leicester
2004-2008: Honorary Lecturer, Cardiovascular Study, University of Leicester; Postdoctoral Research Associate, University Hospitals of Leicester
2001-2004: Non-clinical Lecturer, Infection, Immunity and Inflammation, University of Leicester
2000-2001: Postdoctoral Research Assistant, Sheffield Kidney Institute, University of Sheffield
1995-1996: Visiting Research Fellow, Sheffield Kidney Institute, University of Sheffield
1994: Visiting Research Fellow, Institute of Nephrology, University of Beijing
1992-1997: Lecturer & Specialist Registrar in Nephrology, Affiliated Hospital of Nantong University
1989-1992: Research Assistant & House officer, Medicine, Affiliated Hospital of Nantong University
1997.09-2000.07: Doctor of Philosophy in Medicine, awarded PhD in Jan 2002, University of Sheffield
1986.09-1989.07: Doctor of Medicine, Nephrology, awarded MD in Jul 1989, Nantong University
1981.09-1986.07: Bachelor of Medicine, awarded MBChB in Jul 1986, Nantong University

RESEACH HIGHLIGHTS
From 2010, I have led a research team with awarded project and fellowship funding. A series of biological models have established, such as unique isolated kidney perfusion system that has used to preserve human kidney donors before transplantation. Cell culture, rodent and porcine models have been used to study mechanisms of kidney diseases, and human samples such as renal biopsies have been also used to define biomarkers, and validate translational interventions. More recently, I am leading AKI-related clinical studies to further validate selected biomarkers such as SERPINA3 and SILP1 against commonly used NGAL and KIM-1 in urine and blood samples from high-risk patients. I also designed an organ/cell target gene therapy using caspase-3 siRNA conjugated with a ligand peptide (HBSP) that will be guided by its receptors (EPOR/βcR) highly expressed in injured kidneys. To generate siRNA-HBSP conjugate, I am collaborating with colleagues in Chemistry and Preclinical Research Facility in Leicester, and Biomics and Biotechnologies Co Ltd. in China, to maximize productivities and outcomes.

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS
Jiangsu Distinguished Medical Expert, China, since 2016; Visiting Professor: Fudan University, China, since 2009; Distinguished Professor: Nantong University, China, since 2009. Invited speaker for different national and international conferences for more than 30 talks, including UK and China Universities such as King's College London, Sheffield University, and Tongji, Fudan, Shenzhen, Beijing, Nanjing, Yangzhou and Nantong University. Academic member of British Transplantation Society, Renal Association, European Society of Organ Transplantation, the Transplantation Society, and Asia-Pacific Association of Medicine and Bio-Immunology.

SELECTED PUBLICATIONS

65 papers in peer-viewed journals and 52 collected by Web of Science, with impact factor over 200, as the corresponding author or the first author for most papers (see selection list); total citations over 800. Two book chapters: (1) siRNA therapy in acute kidney injury, in RNA Interference，ISBN: 978-953-51-4614-8，Editor: Abdurakhmonov OY, InTech, 2016; (2) Pathogenesis of Chronic Allograft Dysfunction Progress to Renal Fibrosis, in Renal Fibrosis: Mechanisms and Therapies, Advances in Experimental Medicine and Biology, ISBN: 978-981-13-8871-2, Editors: Liu BC et al., Springer Nature Singapore Pte Ltd, 2019.

Yang C, Qi R, Yang B*. Pathogenesis of Chronic Allograft Dysfunction Progress to Renal Fibrosis. Adv Exp Med Biol 2019;1165:101-116
Liu A, Yang B*. Role of TRPM7 in Renal Ischemia-Reperfusion Injury. Curr Protein Pept Sci 2019;20:777
Aifen Liu, Jing Wu, Cheng Yang, Yuanyuan Wu, Yufang Zhang, Fengbo Zhao, Hui Wang, Li Yuan, Lirui Song, Tongyu Zhu, Yaping Fan, Bin Yang*. TRPM7 in CHBP-induced renoprotection upon ischemia reperfusion-related injury. Sci Rep 2018 Apr 3;8(1):5510
Zwaini Z, Dai H, Stover C, Yang B*. Role of Complement Properdin in Renal Ischemia-Reperfusion Injury. Curr Gene Ther 2017;17(6):411-423
Hou-Yong Dai, Li-Na Ma, Yun Cao, Xiao-Lan Chen, Hui Shi, Ya-Ping Fan, Bin Yang*. Protection of CTGF Antibody Against Diabetic Nephropathy in Mice Via Reducing Glomerular β-Catenin Expression and Podocyte Epithelial-Mesenchymal Transition. J Cell Biochem 2017 Nov;118(11):3706-3712
Tang Q, Yang B, Fan F, Li P, Yang L, Guo Y. Effects of individualized exercise program on physical function, psychological dimensions, and health-related quality of life in patients with chronic kidney disease: A randomized controlled trial in China. Int J Nurs Pract 2017;23
Zhang Y, Chen W, Wu Y, Yang B*. Renoprotection and Mechanisms of Erythropoietin and Its Derivatives Helix B Surface Peptide in Kidney Injuries. Curr Protein Pept Sci 2017;18(12):1183
Yang C, Yang B*. Acute kidney injury in China: A neglected truth and perspective. Asian J Urol 2016 Jan;3(1):4-5
Yang C, Zhang C, Zhao Z, Zhu T, Yang B*. Fighting against kidney diseases with small interfering RNA: opportunities and challenges. J Transl Med 2015 Feb 1;13:39
Cheng Yang, Tian Zhao, Zitong Zhao, Yichen Jia, Long Li, Yufang Zhang, Mangen Song, Ruiming Rong, Ming Xu, Michael L Nicholson, Tongyu Zhu, Bin Yang*. Serum-stabilized naked caspase-3 siRNA protects autotransplant kidneys in a porcine model. Mol Ther 2014 Oct;22(10):1817-1828
Zitong Zhao, Cheng Yang, Long Li, Tian Zhao, Lingyan Wang, Ruiming Rong, Bin Yang*, Ming Xu, Tongyu Zhu. Increased peripheral and local soluble FGL2 in the recovery of renal ischemia reperfusion injury in a porcine kidney auto-transplantation model. J Transl Med 2014 Feb 23;12:53
Yuanyuan Wu, Junlin Zhang, Feng Liu, Cheng Yang, Yufang Zhang, Aifen Liu, Lan Shi, Yajun Wu, Tongyu Zhu, Michael L Nicholson, Yaping Fan, Bin Yang*. Protective effects of HBSP on ischemia reperfusion and cyclosporine a induced renal injury. Clin Dev Immunol 2013;2013:758159
Cheng Yang, Long Li, Yinjia Xue, Zitong Zhao, Tian Zhao, Yichen Jia, Ruiming Rong, Ming Xu, Michael L Nicholson, Tongyu Zhu, Bin Yang*. Innate immunity activation involved in unprotected porcine auto-transplant kidneys preserved by naked caspase-3 siRNA. J Transl Med 2013 Sep 13;11:210
Shuai Jiang, Qunye Tang, Ruiming Rong, Liangfeng Tang, Ming Xu, Jidong Lu, Yichen Jia, Yitreen Ooi, Jun Hou, Jianming Guo, Bin Yang*, Tongyu Zhu. Mycophenolate mofetil inhibits macrophage infiltration and kidney fibrosis in long-term ischemia-reperfusion injury. Eur J Pharmacol 2012 Aug 5;688(1-3):56-61
Bin Yang*, Sarah A Hosgood, Michael L Nicholson. Naked small interfering RNA of caspase-3 in preservation solution and autologous blood perfusate protects isolated ischemic porcine kidneys. Transplantation 2011 Mar 15;91(5):501-507

Huangtian Yang

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2017 - Present: Professor, Principal Investigator, Shanghai Institute of Nutrition and Health, CAS
2005 - 2014: Associate Director, Institute of Health Sciences, SIBS, CAS/SJTUSM, China
2003 - 2004: Director Assistant, Institute of Health Sciences, SIBS, CAS/SJTUSM, China
2000 - 2016 : Principal Investigator, Professor, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine
1997 - 2001: Researcher fellow, Laboratory of Cardiovascular Science, Gerontology Research Center, NIA, NIH, USA
1992 - 1997: Instructor, research fellow, Dept. of Pharmacology, Yamagata University School of Medicine, Japan
1989 - 1992: Assistant Professor, Nantong Medical College, China
1982 - 1985: Instructor, Nantong Medical College, China
1992 - 1994: Ph.D. in Medicine, Yamagata University, School of Medicine, Japan
1985 - 1988: M.D in Medicine, Su Zhou Medical College, China
1978 - 1982: B.S in Medicine, Nantong Medical College, China

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS
American Heart Association/American Stroke Association Professional Membership
Chinese Association for Physiological Sciences, Circulation Committee (Council member)
Chinese Association of Pathophysiology, Cardiovascular Sciences and Receptor/Signal Transduction Professional Committee (Council member)
Chinese Association of Plastics and Aesthetics Branch of Stem Cell & Application （Executive member)
Chinese Medical Association for Cardiovascular Disease Branch (Council member)
Chinese Pharmacological Society for Cardiovascular Pharmacology (member of the standing committee)
Chinese Medical Association for Heart Regeneration (Council member)
Chinese Society of Cardiovascular Pharmacology (Council member)
International Society for Heart Research-China Section (Vice Chairman)
Shanghai Society for Cell Biology (Vice-Chairman)
The International Society for Heart Research (Fellow)
Acta Pharmacol Sinica
Acta Physiologica Sinica（Editorial Board of the Standing Committee)
AJP-Heart and Circulatory Physiology
Cardiovascular Drugs and Therapy
Cell Death Disease
Chinese Journal of Applied Physiology
Chinese Journal of Molecular Cardiology
Current Opinion in Physiology
Engineering-Tissue Engineering
Frontier in Pharmacology
J Mol Cell Cardiol (Associate Editor)
Pflügers Archiv - European Journal of Physiology (Executive Editor)

SELECTED PUBLICATIONS

Liu YP^#, Bai HJ^#, Yang CL, Luo XL, Zhang P, Guo FF, Fen XQ, Phung T, Zhu D, Guo J, Liang P, Xu Z, Yang HT*, Lu XY*. PGC-1α Activator ZLN005 Promotes Maturation of Cardiomyocytes Derived from Human Embryonic Stem Cells. Aging. 2020 Apr 28;12(8):7411-7430
Wu Q^#, Wang JX^#, Tan WLW, Jiang Y, Wang SH, Li Q, Yu XJ, Tan JL, Liu SY, Zhang P, Tiang Z, Chen ZY, Foo RSY, Yang HT*. Extracellular vesicles from human embryonic stem cell-derived cardiovascular progenitor cells promote cardiac infarct healing through reducing cardiomyocyte death and promoting angiogenesis. Cell Death & Disease. 2020 May 11;11(5):354
Hu JL^#, Liang H^#, Zhang H^#, Yang MZ^#, Sun W, Zhang P, Luo L, Feng JX, Bai HJ, Liu F, Zhang TP, Yang JY, Gao QS, Long YK, Ma XY, Chen Y, Zhong Q, Yu B, Liao S, Wang YB, Zhao Y, Zeng MS, Cao N, Wang JC, Chen W*, Yang HT*, Gao S*. FAM46B is a prokaryote-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells. Nucleic Acids Research. 2020 Mar 18;48(5):2733-2748
Poon E*, Luo XL, Webb S, Yan B, Zhao R, Wu S, Yang Y, Zhang P, Bai HJ, Shao JF, Chan C, Chan G, Tsang S, Gundry R, Yang HT, Boheler K*. The Cell Surface Marker CD36 Selectively identifies Matured, Mitochondria-rich hPSC-Cardiomyocytes. Cell Res. 2020 Mar 10. doi: 10.1038/s41422-020-0292-y
Bai H J, Zhang P, Ma L, Liang H, Wei G, Yang HT*. SMYD2 drives mesendodermal differentiation of human embryonic stem cells through mediating the transcriptional activation of key mesendodermal genes. Stem Cells. 2019 Nov;37(11):1401-1415
Wang X, Wang L, Wu Q, Bao F, Yang HT*, Qiu X*, Chang J*. Chitosan/Calcium Silicate Cardiac Patch Stimulates Cardiomyocyte Activity and Myocardial Performance after Infarction by Synergistic Effect of Bioactive Ions and Aligned Nanostructure. ACS applied materials & interfaces. 2019;11(1):1449-1468
Wang JX, Liu ML, Wu Q, Li Q, Gao L, Jiang Y, Deng B, Huang W, Bi W, Chen Z, Chin Y, Paul C, Wang Y, Yang HT*. Human Embryonic Stem Cell-Derived Cardiovascular Progenitors Repair Infarcted Hearts through Modulation of Macrophages via Activation of STAT6. Antioxid Redox Signal. 2019 Aug 10;31(5):369-386
Rusinkevich V, Huang Y, Chen ZY, Qiang W, Wang YG, Shi YF, Yang HT*. Temporal dynamics of immune response following prolonged myocardial ischemia/reperfusion with and without cyclosporine A. Acta Pharmacol Sin. 2019 Sep;40(9):1168-1183
Fang X, Wang H, Han D, Xie E, Yang X, Wei J, Gu S, Gao F, Zhu N, Yin X, Cheng Q, Zhang P, Dai W, Chen J, Yang F, Yang HT, Linkermann A, Gu W, Min J, Wang F. Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2672-2680
Tan JL, Shanshan Gu, Yanjun Zheng, Yang HT. Expression Profile of Circular RNAs in Myocardial Ischemia/Reperfusion with and without Intermittent Hypobaric Hypoxia Preconditioning. Sci China Life Sci. 2019 Aug;62(8):1104-1106
Zhu K, Wu Q, Ni C, Zhang P, Zhong Z, Wu Y, Wang Y, Xu Y, Kong M, Cheng H, Tao Z, Yang Q, Liang H, Jiang Y, Li Q, Zhao J, Huang J, Zhang F, Chen Q, Li Y, Chen J, Zhu W, Yu H, Zhang J, Yang HT*, Hu X*, Wang J*. Lack of remuscularization following transplantation of human embryonic stem cell-derived cardiovascular progenitor cells in infarcted nonhuman primates. Circ Res. 2018 Mar 30;122(7):958-969
Wang YJ, Huang J, Liu W, Kou X, Tang H, Wang H, Yu X, Gao S, Ouyang K, Yang HT*. IP3R-mediated Ca²⁺ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin-NFATc3-Etv2 pathway. J Mol Cell Biol. 2017 Aug 1;9(4):274-288. (cover article)
Chen ZY, Chen F, Cao N, Zhou ZW, Yang HT*. miR-142-3p contributes to early cardiac fate decision of embryonic stem cells. Stem Cells Int. 2017;2017:1769298
Zheng Y, Gu S, Li X, Tan J, Liu S, Jiang Y, Zhang C, Gao L, Yang HT*. Berbamine postconditioning protects the heart from ischemia/reperfusion injury through modulation of autophagy. Cell Death Dis. 2017 Feb 2;8(2):e2577
Lu J, Kaestle K, Huang J, Liu Q, Zhang P, Gao L, Gardiner J, Thissen H, Yang HT*. Interactions of human embryonic stem cell-derived cardiovascular progenitor cells with immobilized extracellular matrix proteins. J Biomed Mater Res A. 2017 Apr;105(4):1094-1104
Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang YS, Li S, Cass A, Vondriska TM, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y. The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. Nat Med. 2016;22(10):1131-1139
Huang J, Zhang M, Zhang P, Liang H, Ouyang K, Yang HT*. Coupling switch of P2Y-IP₃ receptors mediates differential Ca²⁺ signaling in human embryonic stem cells and derived cardiovascular progenitor cells. Purinergic Signal. 2016 Sep;12(3):465-478
Tang Y, Hong YZ, Bai HJ, Wu Q, Chen CD, Lang JY, Boheler KR, Yang HT*. PHF8 regulates mesodermal and cardiac differentiation of embryonic stem cells through mediating the histone demethylation of pmaip1. Stem Cells. 2016 Jun;34(6):1527-1540
Wu L, Tan JL, Wang ZH, Chen YX, Gao L, Liu JL, Yun-Hua S, Endoh M, Yang HT*. ROS generated during early reperfusion contribute to intermittent hypobaric hypoxia-afforded cardioprotection against postischemia-induced Ca²⁺ overload and contractile dysfunction via the JAK2/STAT3 pathway. J Mol Cell Cardiol. 2015 Apr;81:150-161
Chen YX, Liu JL, Zheng YJ, Wang JX, Wang ZH, Gu SS, Tan JL, Jing Q, Yang HT*. Uncoupling Protein 3 Mediates H2O2 Preconditioning-Afforded Cardioprotection through the Inhibition of MPTP Opening. Cardiovasc Res. 2015 Feb 1;105(2):192-202
Ling Gao, Yanjun Zheng, Shanshan Gu, Jiliang Tan, Christian Paul, Yigang Wang, Huangtian Yang*. Degradation of cardiac myosin light chain kinase by matrix metalloproteinase-2 contributes to myocardial contractile dysfunction during ischemia/reperfusion. J Mol Cell Cardiol. 2014 Dec;77:102-112
Wang ZH, Liu JL, Wu L, Yu Z, Yang HT*. Concentration-dependent wrestling between detrimental and protective effects of H2O2 during myocardial ischemia/reperfusion. Cell Death Dis. 2014 Jun 19;5:e1297
Tang Y, Chen ZY, Hong YZ, Wu Q, Lin HQ, Chen CD, Yang HT*. Expression profiles of histone lysine demethylases during cardiomyocyte differentiation of mouse embryonic stem cells. Acta Pharmacol Sin. 2014 Jul;35(7):899-906
Gao L, Chen L, Lu ZZ, Gao H, Wu L, Chen YX, Zhang CM, Jiang YK, Jing Q, Zhang Y, Yang HT*. Activation of α1B-adrenoceptors contributes to intermittent hypobaric hypoxia-improved post-ischemic myocardial performance via inhibiting MMP-2 activation. Am J Physiol Heart Circ Physiol. 2014 Jun 1;306(11):H1569-H1581
Cao N, Liang H, Huang J, Wang J, Chen Y, Chen Z, Yang HT*. Highly efficient induction and long-term maintenance of multipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions. Cell Res. 2013 Sep;23(9):1119-1132
Zhang CM, Gao L, Zheng YJ, Yang HT*. Berbamine Protects the Heart From Ischemia/Reperfusion Injury by Maintaining Cytosolic Ca²⁺ Homeostasis and Preventing Calpain Activation. Circ J. 2012;76(8):1993-2002
Wang ZH, Cai XL, Wu L, Zhuo Y, Liu JL, Zhou ZN, Liu JK, Yang HT*. Mitochondrial Energy Metabolism Plays a Critical Role in the Cardioprotection Afforded by Intermittent Hypobaric Hypoxia. Exp Physiol. 2012 Oct;97(10):1105-1118
Wang J, Cao N, Yuan M, Cui H, Tang Y, Qin LJ, Huang X, Shen N, Yang HT*. MicroRNA-125b/Lin28 pathway contributes to the mesendodermal fate decision of embryonic stem cells. Stem Cells Dev. 2012 Jun 10;21(9):1524-1537
Cao N, Liu Z, Chen Z, Wang J, Chen T, Zhao X, Ma Y, Qin L, Kang J, Wei B, Wang L, Jin Y, Yang HT*. Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells. Cell Res. 2012 Jan;22(1):219-236
Wang ZH, Chen YX, Zhang CM, Wu L, Yu Z, Cai XL, Guan Y, Zhou ZN, Yang HT*. Intermittent Hypobaric Hypoxia Improves Post-ischemic Recovery of Myocardial Contractile Function via Redox Signaling during Early Reperfusion. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1695-H1705
Zhang CM, Gao L, Zheng YJ, Yang HT*. Berbamine Increases Myocardial Contractility via a Ca²⁺-independent Mechanism. J Cardiovasc Pharmacol. 2011 Jul;58(1):40-48
Cao N, Liao J, Liu Z, Zhu W, Wang J, Liu L, Yu L, Xu P, Cui C, Xiao L, Yang HT*. In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes. Cell Res. 2011 Sep;21(9):1316-1331
Xu WQ, Yu Z, Xie Y, Huang GQ, Shu XH, Zhu Y, Zhou ZN, Yang HT*. Therapeutic effect of intermittent hypobaric hypoxia on myocardial infarction in rats. Basic Res Cardiol. 2011 May;106(3):329-342
Liang J, Wang YJ, Tang Y, Cao N, Wang J, Yang HT*. Type 3 inositol 1,4,5-trisphosphate receptor negatively regulates apoptosis during mouse embryonic stem cell differentiation. Cell Death Differ. 2010 Jul;17(7):1141-1154

BOOK CHAPTERS

Nan Cao, He Liang, Huangtian Yang*. Generation, Expansion, and Differentiation of Cardiovascular Progenitor Cells from Human Pluripotent Stem Cells. Edited by Kursad Turksen, Ph.D., Cell-Cell Communications in Stem Cell Renewal: Methods Mol Biol. published by Springer 2015;1212:113-125
Yang HT*, Yi Zhang, Wang ZH and Zhou ZN. Chapter 4. Protective effects of chronic intermittent hypoxia against myocardial ischemia/reperfusion injury, p47-58 in the book Intermittent hypoxia and human diseases, Edited by Dr. Lei Xi and Dr. Tatiana V. Serebrovskaya, published by Springer (http://www.springerlink.com/content/978-1-4471-2905-9/?MUD=MP) in 2012
Huangtian Yang*, Zhaonian Zhou, Le Chen. Effects and mechanism of hypoxia on cardiovascular function. P416-424. In Cardiovascular Physiology: Basic Science and Clinical Relevance. High Education Press, China, 2010

Dongmin Yin

Professor, Institute of Brain Functional Genomics, East China Normal University
Address: Room 106, 3663 Zhongshan Road N., Shanghai, China 200062
Telephone: 86-21-62238357
E-mail: dmyin@brain.ecnu.edu.cn

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
07/2014-present: Professor, Institute of Brain Functional Genomics, East China Normal University
2013.10-2014.07: Assistant Research Scientist, Department of Neuroscience and Regenerative Medicine, Georgia Regents University
2008.08-2013.10: Postdoctoral Fellow, Institute of molecular medicine and genetics, Georgia Regents University
2003.09-2008.07: Ph.D., Neuroscience Research Institute, Peking University, Beijing, China
1998.09-2003.07: M.D., Nanjing Medical University, Nanjing, China

HONORS, PRIZES AND AWARDS
Best Students Award, the Society for Neuroscience, China, 2009
Outstanding Thesis Award (Ph. D. thesis), Peking University, 2010
NASADR Young Investigator Award, Brain & Behavior Research Foundation, 2012
Shanghai Rising-Star in Science and Technology, 2015
Eastern Scholar at Shanghai Institutions of Higher Learning, 2015

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS
Member, the Society for Neuroscience, China, 2005-2007
Member, the Society for Neuroscience, USA, 2008-present
Reviewer, Molecular Brain, Plos One, 2010-present
Reviewer, Aging Research Reviews, Hippocampus, Molecular Psychiatry, 2013-present
Reviewer, Nature Communication, Scientific Reports, 2015-present

PRESENTATIONS AT NATIONAL, REGIONAL AND STATE MEETINGS

D YIN, JC BEAN, WC XIONG, L MEI. PIN1 enhances the stability of ErbB4. Annual meeting, the Society for Neuroscience, Chicago, 2009
J BEAN, D YIN, WC XIONG, L MEI. PIN1 regulates spine formation. Annual meeting, the Society for Neuroscience, Chicago, 2009
D YIN, YJ CHEN, YS LU, A SATHYAMURTHY, J BEAN, C SMITH, C SHEN, X LIU, WC XIONG, L MEI. Reversal of schizophrenia-relevant behavioral deficits in neuregulin 1 transgenic mice. Annual meeting, the Society for Neuroscience, Washington DC, 2012
D YIN, J BEAN, L THIRI, A SATHYAMURTHY, WC XIONG, YJ. CHEN, L MEI. Regulation of spine formation by ErbB4 in PV-positive interneurons. US-Japan meeting “Current Trends and Future Directions of Synaptic Plasticity Research”, University of Washington, Seattle, 2013
D YIN, J BEAN, L THIRI, A SATHYAMURTHY, WC. XIONG, YJ. CHEN, L MEI. Regulation of spine formation by ErbB4 in PV-positive interneurons. Annual meeting, the Society for Neuroscience, San Diego, 2013
D YIN. Role of Neuregulin 1 in synapse formation and transmission and its implication in schizophrenia relevant endophenotype. Symposium for Chinese Neuroscientists Worldwide, Suchow, 2014

SELECTED PUBLICATIONS

Zhang HL, Long JW, Han W, Wang J, Song W, Lin GN, Yin DM*. Comparative analysis of cellular expression pattern of schizophrenia risk genes in human versus mouse cortex. Cell Biosci. 2019 Nov 4;9:89
Yu Q, Liu YZ, Zhu YB, Wang YY, Li Q, Yin DM*. Genetic labeling reveals temporal and spatial expression pattern of D2 dopamine receptor in rat forebrain. Brain Struct Funct. 2019 Apr;224(3):1035-1049
Tan Z, Robinson HL, Yin DM, Liu Y, Liu F, Wang H, Lin TW, Xing G, Gan L, Xiong WC, Mei L*. Dynamic ErbB4 Activity in Hippocampal-Prefrontal Synchrony and Top-Down Attention in Rodents. Neuron 2018 Apr 18;98(2):380-393
Zhu YB#, GW#, Zhang Y#, Feng J, Zhang HL, Liu YZ, Sun XF, Yin Y, Yin DM*. Astrocyte-derived phosphatidic acid promotes dendritic branching. Sci Rep 2016 Feb 17;6:21096
Yin DM#, Chen YJ#, Liu S, Jiao H, Shen C, Sathyamurthy A, Lin TW, Xiong WC, Li BM, Mei L*, Bergson C*. Calcyon Stimulates Neuregulin 1 Maturation and Signaling. Mol Psychiatry 2015 Oct;20(10):1251-1260
Sathyamurthy A, Yin DM, Barik A, Shen C, Bean JC, Figueiredo D, She JX, Xiong WC, Mei L*. ERBB3-mediated regulation of Bergmann glia proliferation in cerebellar lamination. Development 2015;142:522-532
Lu Y#, Sun XD#, Hou FQ, Bi LL, Yin DM, Liu F, Chen YJ, Bean JC, Jiao HF, Liu X, Li BM, Xiong WC, Gao TM*, Mei L*. Maintenance of GABAergic activity by neuregulin1-ErbB4 in amygdala for fear memory. Neuron 2014;84:835-846
Bean JC, Lin TW, Sathyamurthy A, Yin DM, Xiong WC, Mei L*. Genetic labeling reveals novel cellular targets of schizophrenia susceptibility gene: distribution of GABA and non-GABA ErbB4-positive cells in adult mouse brain. J Neurosci 2014;34:13549-13566
Yin DM, Sun XD, Bean JC, Lin TW, Sathyamurthy A, Xiong WC, Gao TM, Chen YJ*, Mei L*. Regulation of spine formation by ErbB4 in PV-positive interneurons. J Neurosci 2013;33:19295-19303
Yin DM, Xiong WC, Mei L*. Adolescent dopamine slows spine maturation. Nat Neurosci 2013;16:1514-1516
Yin DM#, Chen YJ#, Lu YS, Bean JC, Sathyamurthy A, Shen C, Liu X, Lin TW, Smith AC, Xiong WC, Mei L*. Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1. Neuron 2013;78:644-657 (high-lighted in Preview by O. Marin and B. Rico, Neuron 2013;78:577-579)
Zhu YB#, Kang K#, Zhang Y, Qi C, Li G, Yin DM*, Wang Y*. PLD1 negatively regulates dendritic branching. J Neurosci 2012;32:7960-7969 (high-lighted by “F1000”)
Tan GH#, Liu YY#, Hu XL, Yin DM, Mei L*, Xiong ZQ*. Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. Nat Neurosci 2012;15:258-266 (high-lighted in News & Views by K. Narasimhan, Nat Neurosci 2012;15:179)
Liu X, Bates R, Yin DM, Shen C, Wang F, Su N, Kirov SA, Luo Y, Wang JZ, Xiong WC, Mei L*. Specific regulation of NRG1 isoform expression by neuronal activity. J Neurosci 2011;31:8491-8501
Ting AK, Chen Y, Wen L, Yin DM, Shen C, Tao Y, Liu X, Xiong WC, Mei L*. Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons. J Neurosci 2011;31:15-25
Chen YJ, Zhang M, Yin DM, Wen L, Ting A, Wang P, Lu YS, Zhu XH, Li SJ, Wu CY, Wang XM, Lai C, Xiong WC, Mei L*, Gao TM*. ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation. Proc Natl Acad Sci U S A 2010;107:21818-21823
Zhang Y, Su P, Liang P, Liu T, Liu X, Liu XY, Zhang B, Han T, Zhu YB, Yin DM, Li J, Zhou Z, Wang KW, Wang Y. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit. J Neurosci 2010;30:7575-7586
Wen L#, Lu YS#, Zhu XH#, Li XM, Woo RS, Chen YJ, Yin DM, Lai C, Terry AV Jr, Vazdarjanova A, Xiong WC, Mei L*. Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons. Proc Natl Acad Sci U S A 2010;107:1211-1216

Faming Zhang

Dr. Zhang graduated from the Fourth Military Medical University, China. After he had clinical speciality in gastroenterology, Dr. Zhang had visiting scholarship at the Johns Hopkins Hospital from 2011 to 2012. In recent years, Dr. Zhang leads his team focusing on therapeutic innovations in microbiome in Nanjing Medical University. He and his team developed the first automatic system (GenFMTer) for washed microbiota transplantation (WMT), supported China fecal microbiota bank (fmtBank) for providing national non-profit rescue WMT service, and sponsored China Microbiota Transplantation System for long-term safety evaluation and management on microbiota transplantation. His innovations involve with interventional intestinal diseases, such as colonic transendoscopic enteral tubing (TET), the quick endoscopic mid-gut TET, cap assisted endoscopic sclerotherapy (CAES). Colonic TET is making repeat microbiota transplantation through whole colon be true in practice. He and his group reported the step-up FMT strategy for steriods dependent IBD. Dr. Zhang is the co-chair of China Gut Festival which is leading conference on microbiota related diseases with over 5000 attendees in 2019.

SELECTED PUBLICATIONS

Fecal Microbiota Transplantation-standardization Study Group. Nanjing consensus on methodology of washed microbiota transplantation. Chin Med J (Engl) 2020 Jul 21. doi: 10.1097/CM9.0000000000000954 Lead author
Ding X, Li Q, Li P, Chen X, Xiang L, Bi L, Zhu J, Huang X, Cui B, Zhang F. Fecal microbiota transplantation: A promising treatment for radiation enteritis? Radiother Oncol 2020.143：12-18
Zhang T, Lu G, Zhao Z, Liu Y, Shen Q, Li P, Chen Y, Yin H, Wang H, Marcells C, Cui B, Cheng L, Ji G, Zhang F. Washed microbiota transplantation vs. manual fecal microbiota transplantation: clinical findings, animal studies and in vitro screening. Protein Cell 2020;11(4):251-266
Xiang L, Ding X, Li Q, Wu X, Dai M, Long C, He Z, Cui B, Zhang F. Efficacy of faecal microbiota transplantation in Crohn's disease: a new target treatment? Microb Biotechnol 2020;13(3):760-769
Dai M, Liu Y, Cheng W, Buch H, Shan Y, Chang L, Bai Y, Shen C, Zhang X, Huo Y, Huang D, Yang Z, Hu Z, He X, Pan J, Hu L, Pan X, Wu X, Deng B, Li Z, Cui B, Zhang F*. Rescue fecal microbiota transplantation for antibiotic-associated diarrhea in critically ill patients. Crit Care 2019 Oct 21;23(1):324
Wu X, Dai M, Buch H, Bai J, Long W, Long C, Tang X, Tu H, Zhang R, Zhu C, Yang S, Cui B, Ji G, Zhang F. The recognition and attitudes of postgraduate medical students towards fecal microbiota transplantation: a questionnaire study. Therap Adv Gastroenterol 2019 Sep 2;12:1756284819869144
Zhang F, Zhang T, Zhu H, Borody TJ. Evolution of Fecal Microbiota Transplantation in Methodology and Ethical Issues. Curr Opin Pharmacol 2019;49:11-16
Wu X, Zhang T, Chen X, Ji G, Zhang F. Microbiota Transplantation: Targeting Cancer Treatment. Cancer Lett 2019 Jun 28;452:144-151
Ding X, Li Q, Li P, Zhang T, Cui B, Ji G, Lu X, Zhang F. Long-term safety and efficacy of fecal microbiota transplant in active ulcerative colitis. Drug Safety 2019;42(7):869–880
Li P, Zhang T, Xiao Y, Tian L, Cui1 B, Ji G, Liu YY, Zhang F. Timing for the second fecal microbiota transplantation to maintain the long-term benefit from the first treatment for Crohn's disease. Appl Microbiol Biotech 2019;103(1):349-360
Zhang F, Cui B, He X, Nie Y, Wu K, Fan D, FMT-standardization Study Group. Microbiota transplantation: Concept, methodology and strategy. Protein Cell 2018;9(5):462-473
Long C, Yu Y, Cui B, Jagessar SA, Zhang J, Ji G, Huang G, Zhang F. A novel quick transendoscopic enteral tubing in mid-gut: technique and training with video. BMC Gastroenterol 2018;18(1):37
Peng Z, Xiang J, He Z, Zhang T, Xu L, Cui B, Li P, Huang G, Ji G, Nie Y, Wu K, Fan D, Zhang F. Colonic transendoscopic enteral tubing: A novel delivering way for fecal microbiota transplantation. Endosc Int Open 2016;04(06):E610-E613
Cui B, Li P, Xu L, Peng Z, Xiang J, He Z, Zhang T, Ji G, Nie Y, Wu K, Fan D, Zhang F. Step-up fecal microbiota transplantation (FMT) strategy. Gut Microbes 2016;7(4):323-328
Cui B, Li P, Xu L, Zhao Y, Wang H, Peng Z, Xu H, Xiang J, He Z, Zhang T, Nie Y, Wu K, Fan D, Ji G, Zhang F. Step-up fecal microbiota transplantation strategy: a pilot study for steroid-dependent ulcerative colitis. J Transl Med 2015;13(1):298
Cui B, Feng Q, Wang H, Wang M, Peng Z, Li P, Huang G, Liu Z, Wu P, Fan Z, Ji G, Wang X, Wu K, Fan D, Zhang F. Fecal microbiota transplantation through mid-gut for refractory Crohn's disease: Safety, feasibility, and efficacy trial results. J Gastroenterol Hepatol 2015;30(1):51-58

Weizhen Zhang

Professor of Physiology at Peking University Health Science Center, AGA Fellow. Dr. Zhang received his bachelor in medicine from Sun Yat-sen University of Medical Sciences in 1987, and Ph.D. from Beijing Medical University in 1994. Dr. Zhang is serving as the president-elected of endocrinology and metabolism committee and vice president of gastroenterology and nutrition of Chinese Association for Physiological Sciences, vice president of endocrinology and metabolism committee of Chinese Association of Pathophysiology. Dr. Zhang's research focuses on defining the mechanisms by which gut interacts with metabolic organs to regulate glucose and lipid metabolism. He is the pioneer in the definition of gastric fuel sensing mechanism. His works unravel the mechanism by which gastric endocrine cells sense the fuel supply to coordinate the production of gastric hormones with fuel status at the organism levels. The gastric hormones then function to modulate the food intake as well as glucose and lipid homeostasis. He is the author of over 150 peer-reviewed manuscripts in prestigious journal such as Hepatology, Nature Communications, PNAS and Diabetes. He has been invited to serve as the standing or Ad hoc committee member for a variety of journals and funding agencies including NSFC and ADA, to deliver numerous visiting professor lectures and presentations. He is currently an editor-in-chief of two journals and editor board member of three other journals.

SELECTED PUBLICATIONS

Li Z, Yu R, Yin W, Qin Y, Ma L, Mulholland M, Zhang W. mTOR signaling in X/A-like cells contributes to lipid homeostasis. Hepatology 2019;69:860-875
Mao Z, Lin H, Su W, Li J, Zhou M, Li Z, Zhou B, Yang Q, Zhou M, Pan K, He J, Zhang W. Deficiency of ZnT8 promotes adiposity and metabolic dysfunction by increasing peripheral serotonin production. Diabetes 2019;68(6):1197-1209
He R, Yin Y, Ding L, Li Y, Zhao J, Zhang W. Prevention of pancreatic cancer by Roux-en-Y gastric bypass surgery. Nat Commun 2018;9(1):4183
Xiang X, Lan H, Tang H, Yuan F, Xu Y, Zhao J, Li Y, Zhang W. TSC1-mTOR signaling determines brown-to-white adipocyte phenotypic switch. Diabetes 2015;64(2):519-528
Li Z, Xu G, Qin Y, Zhang C, Tang H, Yin Y, Xiang X, Li Y, Zhao J, Mulholland M, Zhang W. Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPAR signaling pathway. Proc Natl Acad Sci USA 2014; 111(36):13163-13168

Xiaoyan Zhang

Professor of Physiology at Peking University Health Science Center, AGA Fellow. Dr. Zhang received his bachelor in medicine from Sun Yat-sen University of Medical Sciences in 1987, and Ph.D. from Beijing Medical University in 1994. Dr. Zhang is serving as the president-elected of endocrinology and metabolism committee and vice president of gastroenterology and nutrition of Chinese Association for Physiological Sciences, vice president of endocrinology and metabolism committee of Chinese Association of Pathophysiology. Dr. Zhang's research focuses on defining the mechanisms by which gut interacts with metabolic organs to regulate glucose and lipid metabolism. He is the pioneer in the definition of gastric fuel sensing mechanism. His works unravel the mechanism by which gastric endocrine cells sense the fuel supply to coordinate the production of gastric hormones with fuel status at the organism levels. The gastric hormones then function to modulate the food intake as well as glucose and lipid homeostasis. He is the author of over 150 peer-reviewed manuscripts in prestigious journal such as Hepatology, Nature Communications, PNAS and Diabetes. He has been invited to serve as the standing or Ad hoc committee member for a variety of journals and funding agencies including NSFC and ADA, to deliver numerous visiting professor lectures and presentations. He is currently an editor-in-chief of two journals and editor board member of three other journals.

SELECTED PUBLICATIONS (* correspondence author; # first author)

Hu Xu#, Bingying Fang#, Shengnan Du#, Sailun Wang, Qingwei Li, Xiao Jia, Chengzhen Bao, Lan Ye, Xue Sui, Lei Qian, Zhilin Luan, Guangrui Yang, Feng Zheng, Nanping Wang, Lihong Chen*, Xiaoyan Zhang*, Youfei Guan*. Endothelial cell prostaglandin E2 receptor EP4 is essential for blood pressure homeostasis. JCI Insight 2020 Jul 9;5(13):e138505
Wang B#, Zhang H, Luan Z, Xu H, Wei Y, Zhao X, Xing M, Huo X, Zhang J, Su W, Guan Y, Zhang X*. Farnesoid X receptor (FXR) activation induces the antioxidant protein metallothionein 1 expression in mouse liver. Exp Cell Res 2020 May 1;390(1):111949
Xu H#, Du S#, Fang B#, Li C#, Jia X, Zheng S, Wang S, Li Q, Su W, Wang N, Zheng F, Chen L, Zhang X*, Gustafsson JÅ*, Guan Y*. VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure. Proc Natl Acad Sci U S A 2019 Apr 23;116(17):8457-8462
Xu S#, Huang S#, Luan Z#, Chen T, Wei Y, Xing M, Li Y, Du C, Wang B, Zheng F, Wang N, Guan Y*, Gustafssond J-A*, Zhang X*. Farnesoid X receptor is essential for the survival of renal medullary collecting duct cells under hypertonic stress. Proc Natl Acad Sci U S A 2018 May 22;115(21):5600-5605
Peng J#, Yu J, Xu H, Kang C, Shaule PW, Guan Y, Zhang X*, Su W*. Enhanced Liver Regeneration After Partial Hepatectomy in Sterol Regulatory Element- Binding Protein (SREBP)-1c-Null Mice is Associated with Increased Hepatocellular Cholesterol Availability. Cell Physiol Biochem 2018;47(2):784-799
Zhang X#, Yang W#, Wang J#, Meng Y, Guan Y, Yang J. FAM3 gene family: a promising therapeutical target for NAFLD and type 2 diabetes. Metabolism 2018 Apr;81:71-82
Zhou Y#, Yu J, Liu J, Cao R, Su W, Li S, Ye S, Zhu C, Zhang X, Xu H, Chen H, Zhang X*, Guan Y*. Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice. Biochim Biophys Acta Mol Basis Dis 2018 Mar;1864(3):860-870
Li Y#, Wei Y, Zheng F, Guan Y*, Zhang X*. Prostaglandin E2 in the Regulation of Water Transport in Renal Collecting Ducts. Int J Mol Sci 2017 Nov 27;18(12):2539 (Invited review)
Zhang X#, Li S#, Zhou Y#, Su W, Ruan X, Wang B, Zheng F, Warner M, Gustafsson JA*, Guan Y*. Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis. Proc Natl Acad Sci U S A 2017 Mar 21;114(12):3181-3185
Wen Su#, Jun Peng#, Chun-jiong Wang, Sha Li, Yu-bing Dai, Hu Xu, Min Gao, Xiong-zhong Ruan, Jan-Åke Gustafsson, You-fei Guan, Xiao-yan Zhang*. Liver X receptor α induces 17β-hydroxysteroid dehydrogenase-13 expression through SREBP-1c. Am J Physiol Endocrinol Metab 2017 Apr 1;312(4):E357-E367
Su W#, Huang SZ, Gao M, Kong XM, Gustafsson JA, Xu SJ, Wang B, Zheng F, Chen LH, Wang NP, Guan YF, Zhang XY*. Liver X Receptor β (LXRβ) Increases AQP2 Protein Level via a Post-transcriptional Mechanism in Renal Collecting Ducts. Am J Physiol Renal Physiol 2017 Apr 1;312(4):F619-F628
Zhang X#*, Wang B, Guan Y. Nuclear Receptor Regulation of Aquaporin-2 in the Kidney. Int J Mol Sci 2016,17(7):1105

Xing Zhang

Associate Professor, School of Aerospace Medicine, Fourth Military Medical University
Address: 169 Changlexi Road, Xi’an 710032, China
Tel: 86-29-83 (office); 86-15309225008 (mobile)
E-mail: zhangxing@fmmu.edu.cn; lbmed@163.com

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2018-present: School of Aerospace Medicine, Fourth Military Medical University, Associate Professor
2015-2018: School of Aerospace Medicine, Fourth Military Medical University, Lecturer
2013-2015: Department of Physiology, Fourth Military Medical University, Lecturer
2009–2013: Fourth Military Medical University, Physiology, Ph.D.
2006–2009: Fourth Military Medical University, Biomedical Engineering, Master of Engineering
2001–2006: Fourth Military Medical University, Biomedical Engineering, Bachelor of Engineering

SELECTED PUBLICATIONS (# first author; * corresponding author)

Li J#, Xu J#, Qin X, Yang H, Han J, Jia Y, Zhu H, Zhu L, Li J, Xie W, Hu D, Zhang X*, Gao F*. Acute pancreatic beta cell apoptosis by IL-1β is responsible for postburn hyperglycemia: Evidence from humans and mice. Biochim Biophys Acta Mol Basis Dis 2019 Feb 1;1865(2):275-284
Guo Y, Wang Z, Qin X, Xu J, Hou Z, Yang H, Mao X, Xing W, Li X, Zhang X*, Gao F*. Enhancing fatty acid utilization ameliorates mitochondrial fragmentation and cardiac dysfunction via rebalancing opa1 processing in the failing heart. Cardiovasc Res 2018 Jun 1;114(7):979–991
Zhang X, Gao F. Exercise is good for the heart, but the intensity matters. Am J Physiol Heart Circ Physiol 2017 Sep 1;313(3):H546-H547
Li T, Xu J, Qin X, Hou Z, Guo Y, Liu Z, Wu J, Zheng H, Zhang X*, Gao F*. Glucose oxidation positively regulates glucose uptake and improves cardiac function recovery after myocardial reperfusion. Am J Physiol Endocrinol Metab 2017 Nov 1;313(5):E577-E585
Wang X#, Zhang X#, Wu D#, Huang Z, Hou T, Jian C, Yu P, Lu F, Zhang R, Sun T, Li J, Qi W, Wang Y, Gao F, Cheng H. Mitochondrial flashes regulate ATP homeostasis in the heart. Elife 2017 Jul 10;6:e23908
Wang X#, Zhang X#, Huang Z#, Wu D, Liu B, Zhang R, Yin R, Hou T, Jian C, Xu J, Zhao Y, Wang Y, Gao F, Cheng H. Protons trigger mitochondrial flashes. Biophys J 2016 Jul 26;111(2):386-394
Xu J, Qin X, Cai X, Yang L, Xing Y, Li J, Zhang L, Tang Y, Liu J, Zhang X*, Gao F*. Mitochondrial jnk activation triggers autophagy and apoptosis and aggravates myocardial injury following ischemia/reperfusion. Biochim Biophys Acta 2015 Feb;1852(2):262-270
Zhang X, Gao F. Imaging mitochondrial reactive oxygen species with fluorescent probes: Current applications and challenges. Free Radic Res 2015 Apr;49(4):374-382
Zhang X#, Xu J#, Cai X#, Ji L, Li J, Cao B, Hu D, Li Y, Wang H, Xiong L, Xiao R, Gao F. Acute insulin resistance mediated by advanced glycation endproducts in severely burned rats. Crit Care Med 2014 Jun;42(6):e472-e480
Zhang X#, Huang Z#, Hou T, Xu J, Wang Y, Shang W, Ye T, Cheng H, Gao F, Wang X. Superoxide constitutes a major signal of mitochondrial superoxide flash. Life Sci 2013 Aug 6;93(4):178-186
Hou T#, Zhang X#, Xu J, Jian C, Huang Z, Ye T, Hu K, Zheng M, Gao F, Wang X, Cheng H. Synergistic triggering of superoxide flashes by mitochondrial ca2+ uniport and basal reactive oxygen species elevation. J Biol Chem 2013 Feb 15;288(7):4602-4612

Ying Zhang

Ph.D., Associate Professor, Neuroscience Research Institute, Peking University
Address: 38 Xueyuan Road, Haidian District, Beijing
Tel: (86-10) 8280-1067 (Office) 8280-5293 (lab)
Email: zhangyingnri@bjmu.edu.cn

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2014.08-present: Associate Professor, Neuroscience Research Institute, Peking University
2015.07-2016.06: Visiting Scientist in the Department of Neurobiology, Harvard Medical School, Director: Prof. Qiufu Ma
2007.08-2014.07: Assistant Professor, Neuroscience Research Institute, Peking University
2002.09-2007.07: Ph.D., Neuroscience Research Institute, Peking University, Director: Prof. Yun Wang
1997.09-2002.07: B.M., Nursing School, Peking University Health Science Center

HONORS, PRIZES AND AWARDS
2019: First prize for the excellent paper in the Medical Education Symposium in Peking University
2018: Second prize for the excellent paper published in Chinese Journal of Pain medicine
2014: Lvye Eminent Young Scholar Fellowship in Peking University
2013: Excellent Teaching Management Award in Peking University Health Science Center
2012: Excellent Young Scholar in Peking University Health Science Center
2011: Excellent Teaching Award in Peking University Health Science Center

SELECTED PUBLICATIONS (# first author; * Corresponding author)

Guo YP, Zhi YR, Liu TT, Wang Y, Zhang Y*. Global Gene Knockout of Kcnip3 Enhances Pain Sensitivity and Exacerbates Negative Emotions in Rats. Front Mol Neurosci 2019 Jan 25;12:5 eCollection 2019
Huang T, Lin SH, Malewicz NM, Zhang Y, Zhang Y, Goulding M, LaMotte RH, Ma Q*. Identifying the pathways required for coping behaviours associated with sustained pain. Nature 2019 Jan;565(7737):86-90
Tian NX*, Xu Y*, Yang JY, Li L, Sun XH, Wang Y, Zhang Y*. KChIP3 N-terminal 31-50 fragment mediates its association with TRPV1 and alleviates inflammatory hyperalgesia in rats. J Neurosci 2018 Feb 14;38(7):1756-1773
Huang M, Cheng G, Tan H, Qin R, Zou YM, Wang YCA, Zhang Y. Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors. Exp Neurol 2017;295:66-76
Wang GQ*, Cen C*, Li C*, Cao S*, Wang N, Zhou Z, Liu XM, Xu Y, Tian NX, Zhang Y, Wang J, Wang LPCA, Wang Y. Deactivation of excitatory neurons in the prelimbic cortex via Cdk5 promotes pain sensation and anxiety. Nat Commun 2015;16(6):7660
Zhang Y*, Wang N*, Su P, Lu J, Wang Y. Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice. Neurosci Bull 2014;30(6):1025-1035
Wang N*, Su P*, Zhang Y*, Lu J*, Xing BM, Kang K, Li WQ, Wang Y. Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses. Neuropsychopharmacol 2014;39(5):1290-1301
Li Y*, Hu F*, Chen HJ*, Du YJ, Xie ZY, Zhang Y, Wang JCA, Wang Y. LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats. Sci Signal 2014;7(331):ra61
Xing BM*, Yang YR*, Du JX*, Chen HJ, Qi C, Huang ZH, Zhang YCA, Wang Y. Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B. J Neurosci 2012;32(42):14709-14721
Zhu YB*, Kang K*, Zhang Y, Qi C, Li G, Yin DMCA and Wang Y. PLD1 negatively regulates dendritic branching. J Neurosci 2012;32(23):7960-7969
Chen HJ*, Xie WY*, Hu F, Zhang Y, Wang J, Wang Y. Disruption of δ-opioid receptor phosphorylation at Threonine 161 attenuates morphine tolerance in rats with CFA-induced inflammatory hypersensitivity. Neurosci Bull 2012;28(2):182-192
Zhang Y*, Su P*, Liang P, Liu T, Liu X, Liu XY, Zhang B, Zhu YB, Yin DM, Li JF, Zhou Z, Wang KW, Wang Y. The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit. J Neurosci 2010;30(22):7575-7586

Yong Zhang

Professor of Exercise Physiology, Director, Tianjin Key Lab. of Exercise Physiology and Sports Medicine, Tianjin University of Sport
Address: No.16 Donghai Rd. West Tuanbo New Town, Jinghai District, Tianjin, 301617, China
Zip: 301617
Tel: +86-22-23012508(O)
Email: yzhang@tjus.edu.cn

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2001-2002: SCU International visit Professor at the Dept. of Exercise Science and Sports Management, Southern Cross University, Australia
1999-present: Professor, Tianjin University of Sport, China
1996-1999: Associate Professor, Tianjin Institute of Physical Education(percent named TUS), China
1987-1990: Lecturer, Department of Physical Education, Jianghan University, Wuhan, China
1993-1996: Postgraduate study for Ph.D. in Exercise Physiology, Department of Exercise Science, Beijing Sport University, Beijing, China
1990-1993: Postgraduate study for Master of Science in Exercise Physiology, Tianjin University of Sport, Tianjin, China
1978-1982: Undergraduate study for Bachelor of Biology, Department of Biology, Hubei University, Wuhan, China

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS
Executive Council Member, China Sports Sciences Society (CSSS)
Vice-President, Chinese Association of Exercise Physiology and Sports Biochemistry (CSSS)
President, Chinese Association of Stress Physiology (CAPS)
Council Member, Chinese Association of Applied Physiology(CAPS)
Vice-President, Society of Chinese Scholar on Exercise Physiology and Fitness (HK)
Council Member of Asian Society of Mitochondrial Research and Medicine (Korea)

SELECTED PUBLICATIONS

Wang Y, Bo H, Zhang Y*. Research progress in regulation of exercise on mitochondrial respiratory chain supercomplex. Acta Physiologic Sinica 2020 Apr 25;72(2):205-219
Wu JB, Zhang Y*. Research progress in relation between Irisin and disease. Progress in Physiological Science. 2018;49(6):465-470
Zhao F, Pang WT, Zhang ZY, Zhao JL, Wang X, Liu Y, Wang X, Feng ZH, Zhang Y, Sun WY, Liu JK. Pomegranate extract and exercise provide additive benefits on improvement of immune function by inhibiting inflammation and oxidative stress in high-fat diet-induced obesity rats. J Nutr Biochem 2016 Jun;32:20-28
Ji LL*, Kang CH, Zhang Y. Exercise-induced Hormesis and Skeletal Muscle Health. Free Radic Biol Med 2016 Sep;98:113-122
Wang X, Feng ZH, Wang XQ, Yang L, Han SJ, Cao K, Xu J, Zhao J, Zhang Y*, Liu JK*. O-GlcNAcase deficiency suppresses skeletal myogenesis and insulin sensitivity through the modulation of mitochondrial homeostasis. Diabetologia 2016 Jun;59(6):1287-1296
Li HY, Miao WG, Ma JF, Xu Z, Bo H, Li JY, Ji LL, Zhang Y*. Acute exercise-induced mitochondrial stress triggers an inflammatory response in the myocardium via NLRP3 inflammasome activation with mitophagy. Oxid Med Cell Longev 2016;2016:1987149
Bo H, Jiang N, Zhang ZY, Ji LL, Zhang Y*. Exercise and Health: From evaluation of health promoting effect exercise to exploration of exercise minetics. Progress in Physiological Sciences 2014 Aug;45(4):251-256
Bo H, Kang WM, Li HS, Wang X, Ji LL, Zhang Y*. Exercise-induced neuroprotection of hippocampus in APP/PS1 transgenic mice via upregulation of mitochondrial 8-oxoguanine DNA glycosylase. Oxid Med Cell Longev 2014;2014:834502
Wang X, Li H, Zheng A, Yang L, Liu J, Chen C, Tang Y, Zou X, Li Y, Long JG, Liu JK, Zhang Y*, Feng ZH*. Mitochondrial dysfunction-associated OPA1 cleavage contributes to muscle degeneration: preventative effect of hydroxytyrosol acetate. Cell Death Dis 2014 Nov 13;5(11):e1521
Jiang N, Bo H, Song C, Guo J, Zhao F, Feng H, Ding H, Ji LL, Zhang Y*. Increased vulnerability with aging to MPTP: the mechanisms underlying mitochondrial dynamics. Neurol Res 2014 Aug;36(8):722-732
Ji LL, Zhang Y. Antioxidant and Anti-inflammatory Effects of Exercise: Role of Redox Signaling. Free Radic Res 2014 Jan;48(1):3-11
Bo H, Jiang N, Ji LL, Zhang Y. Mitochondrial redox metabolism in aging: Effect of exercise interventions. J Sport Health Sci 2013 Jun;2(2):67-74
Hong Feng, Chounghun Kang, Jonathan R. Dickman, Ryan Koenig, Iwalola Awoyinka, Yong Zhang*, Lili Ji*. Training-induced mitochondrial adaptation: role of peroxisome proliferator-activated receptor γ coactivator-1α, nuclear factor-κB and β-blockade. Exp Physiol 2013 Mar;98(3):784-795
Bo H, Zhang Y*, Ji LL*. Redefining the Role of Mitochondria in Exercise: A Dynamic Remodeling. Ann N Y Acad Sci 2010 Jul;1201:121-128 (invited review)
Liao P, Zhou JP, Ji LL* Zhang Y*. Eccentric contraction induces inflammatory responses in rat skeletal muscle: role of tumor necrosis factor-α. Am J Physiol Regul Integr Comp Physiol 2010 Mar;298(3):R599-R607
Ding H, Jiang N, Liu HJ, Liu DX, Wen L, Liu SS, Ji LL* Zhang Y*. Dynamic Response of Mitochondrial Fusion and Fission Protein Gene Expression to Exercise in Rat Skeletal Muscle. Biochim Biophys Acta 2010 Mar;1800(3):250-256

Hongting Zheng

Director of Department of Endocrinology, Second Affiliated Hospital of Army Medical University, Director of Chongqing Key Laboratory of Diabetes-Translational Medicine
Address: No.183 Xinqiaozheng Road, Shapingba District, Chongqing, China
Phone: 86-68755709
Email: fnf7703@hotmail.com

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2011-present: Chief Physician, Full Professor, M.D. Supervisor, Director of Department of Endocrinology, Second Affiliated Hospital of Army Medical University
2011: University of Arizona, Postdoctoral fellow
2006: Chongqing Medical University, Internal medicine (endocrinology), M.D.
2003: Chongqing Medical University, Internal medicine (endocrinology), M.S.
1998: West China Center of Medical Sciences, Sichuan University, Clinical medicine, B.S.

HONORS, PRIZES AND AWARDS
Top Ten Research Awards of Diabetes in China of 2016
Chinese Medical Science and Technology, second prize
National Outstanding Medical Educational Technology Achievement Award, third prize
Military Academy Education, silver award
Scientific and Technological Progress in Chongqing, first prize
Military Medical Achievement, third prize
Excellent Professional and Technical Talents in the Army

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS
ADA member
CADA permanent member
Society of Endocrinology of Chinese Medical Association committee member
Endocrinology and Metabolism Branch of Chinese Physicians' Association committee member
Diabetes/Hyperuricemia Group of the National Commission Specialized in Endocrine member
Army Commission Specialized in Endocrine member
Diabetes Committee of Chongqing Branch of Chinese Medical Association deputy director
Endocrinology and Metabolism Committee of Chongqing Branch of Chinese Physicians' Association Vice President
Key Projects of the Ministry of Life Sciences/Ministry of Medical Sciences of the National Natural Science Foundation of China peer review expert

SELECTED PUBLICATIONS

Wu T#, Zhang Q#, Wu S, Hu W, Zhou T, Li K, Liu D, Gu HF, Zheng H, Zhu Z, Li L*, Yang G*. CILP-2 is a novel secreted protein and associated with insulin resistance. J Mol Cell Biol 2019 Dec 19;11(12):1083-1094
Yang M#, Liang Z#, Yang M, Jia Y, Yang G, He Y, Li X, Gu HF, Zheng H, Zhu Z, Li L*. Role of bone morphogenetic protein-9 in the regulation of glucose and lipid metabolism. FASEB J 2019 Sep;33(9):10077-10088
Lin Y, Liang Z, He L, Yang M, Liu D, Gu HF, Liu H, Zhu Z, Zheng H, Li L*, Yang G*. Gut ghrelin regulates hepatic glucose production and insulin signaling via a gut-brain-liver pathway. Cell Commun Signal 2019 Jan 25;17(1):8
Zhang K, Guo X, Yan H, Wu Y, Pan Q, Shen JZ, Li X, Chen Y, Li L, Qi Y, Xu Z, Xie W, Zhang W, Threadgill D, He L, Villarreal D, Sun Y, White MF, Zheng H, Guo S*. Phosphorylation of forkhead protein FoxO1 at Ser253 regulates glucose homeostasis in mice. Endocrinology 2019 May 1;160(5):1333-1347
Zhang C#, Luo X#, Chen J#, Zhou B, Yang M, Liu R, Liu D, Gu HF, Zhu Z, Zheng H, Li L*, Yang G*. Osteoprotegerin Promotes Liver Steatosis by Targeting the ERK- PPARγ-CD36 Pathway. Diabetes 2019 Oct;68(10):1902-1914
Cui Y#, Wu H#, Li Q#, Liao J, Gao P, Sun F, Zhang H, Lu Z, Wei X, He C, Ma T, Wei X, Chen X, Zheng H, Yang G, Liu D, Zhu Z*. Impairment of Bitter Taste Sensor Transient Receptor Potential Channel M5-Mediated Aversion Aggravates High-Salt Intake and Hypertension. Hypertension 2019 Oct;74(4):1021-1032
Jia Y#, Niu D#, Li Q#, Huang H, Li X, Li K, Li L, Zhang C, Zheng H, Zhu Z, Yao Y, Zhao X, Li P*, Yang G*. Effective gene delivery of shBMP-9 using polyethyleneimine-based core-shell nanoparticles in an animal model of insulin resistance. Nanoscale 2019;11(4):2008-2016
Zheng Y#, Qu H#, Xiong X#, Wang YR#, Liu XF#, Zhang LL, Liao XY, Liao Q, Sun Z, Ouyang Q, Yang GY, Zhu ZM, Xu J, Zheng HT*. Deficiency of the mitochondrial glycerol 3-phosphate dehydrogenase contributes to hepatic steatosis. Hepatology 2019 Jul;70(1):84-97
Recommended by F1000 Prime http://f1000.com/prime/734876838
Comment by Maria Dalamaga and Junli Liu in Metabolism Open 2019
Zhang R#, Wang H#, Tong Q, Xu J, Long M, Wang X, Wang M, Zhou X, Zheng H*. Tissue biopsy in the diagnosis of chronic tuberculous wounds in diabetes mellitus. Diabetic Medicine 2019 Jul;36(7):908-910
Liao X#, Song L#, Zeng B#, Liu B, Qiu Y, Qu H, Zheng Y, Long M, Zhou H, Wang Y, Du Y, Xu J, Shen R, Tong Q, Cai L, Li X, Guo S, Yang G, Zhu Z, Pu X, Wei H*, Zheng H*. Alteration of gut microbiota induced by DPP-4i treatment improves glucose homeostasis. EBioMedicine 2019 Jun;44:665-674
Mi Q#, Li Y#, Wang M, Yang G, Zhao X, Liu H, Zheng H, Li L*. Circulating C1q/TNF-related protein isoform 15 is a marker for the presence of metabolic syndrome. Diabetes Metab Res Rev 2019 Jan;35(1):e3085
Liu XF#, Qu H#, Zheng Y#, Liao Q#, Zhang LL, Liao XY, Xiong X, Wang YR, Zhang R, Wang H, Tong Q, Liu ZQ, Dong H, Yang GY, Zhu ZM, Xu J, Zheng HT*. Mitochondrial glycerol 3-phosphate dehydrogenase promotes skeletal muscle regeneration. EMBO Mol Med 2018 Dec;10(12):e9390 (cover article)
Recommended by F1000 Prime https://f1000.com/prime/734369687
Lu Z#, Wei X#, Sun F#, Zhang H, Gao P, Pu Y, Wang A, Chen J, Tong W, Li Q, Zhou X, Yan Z, Zheng H, Yang G, Huang Y, Liu D, Zhu Z*. Non-insulin determinant pathways maintain glucose homeostasis upon metabolic surgery. Cell Discov 2018 Sep 25;4:58
Wang M#, Tang X#, Li L, Liu D, Liu H, Zheng H, Deng W, Zhao X*, Yang G*. C1q/TNF-related protein-6 is associated with insulin resistance and the development of diabetes in Chinese population. Acta Diabetol 2018 Dec;55(12):1221-1229
Huang H#, Wang W#, Yang G, Zhang Y, Li X, Liu H, Zhang L, Zheng H, Li L*. Circulating bone morphogenetic protein-9 levels are associated with hypertension and insulin resistance in humans. J Am Soc Hypertens 2018 May;12(5):372-380
Feiyu Jiang, Min Yang, Xili Zhao, Rui Liu, Gangyi Yang, Dongfang Liu, Hua Liu, Hongting Zheng, Zhiming Zhu, Ling Li*. C1q/TNF-Related Protein5 (CTRP5) as a Biomarker to Predict Metabolic Syndrome and Each of Its Components. Int J Endocrinol 2018 Nov 22;2018:7201473
Long M#, Cai LQ#, Li WJ, Zhang LL, Guo SD, Zhang R, Zheng Y, Liu XF, Wang M, Zhou XL, Wang H, Li X, Li L, Zhu ZM, Yang GY, Zheng HT*. DPP-4 Inhibitors Improve Diabetic Wound Healing via Direct and Indirect Promotion of Epithelial-Mesenchymal Transition and Reduction of Scarring. Diabetes 2018 Mar;67(3):518-531
Comment by Max Bingham in the same issue of Diabetes 2018 Mar;67(3):349-350
Qu H#, Qiu Y#, Wang Y#, Liao Y, Zheng Y, Zheng H*. Plasma fetuin-B concentrations are associated with insulin resistance and first-phase glucose-stimulated insulin secretion in individuals with different degrees of glucose tolerance. Diabetes Metab 2018 Dec;44(6):488-492
Li K#, Liao X#, Wang K#, Mi Q, Zhang T, Jia Y, Xu X, Luo X, Zhang C, Liu H, Zhen HT, Li L, Yang G*. Myonectin Predicts the Development of Type 2 Diabetes. J Clin Endocrinol Metab 2018;103(1):139-147
Li K#, Liao X#, Wang K#, Mi Q, Zhang T, Jia Y, Xu X, Luo X, Zhang C, Liu H, Zheng H, Li L, Yang G*. Response to Letter to the Editor: "Myonectin Predicts the Development of Type 2 Diabetes". J Clin Endocrinol Metab 2018 Nov 1;103(11):4040-4041
Wei Q, Zhou B, Yang G, Hu W, Zhang L, Liu R, Li M, Wang K, Gu HF, Guan Y, Zhu Z, Zheng H, Peng J, Li L*. JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism. Cell Death Dis 2018 Aug 28;9(9):859
Lu Zongshi#, Cui Yuanting#, Wei Xing#, Gao Peng*, Zhang Hexuan, Wei Xiao, Li Qiang, Sun Fang, Yan Zhencheng, Zheng Hongting, Yang Gangyi, Liu Daoyan, Zhu Zhiming*. Deficiency of PKD2L1(TRPP3) Exacerbates Pathological Cardiac Hypertrophy by Augmenting NCX1-Mediated Mitochondrial Calcium Overload. Cell Rep 2018 Aug 7;24(6):1639-1652
Wu Y#, Pan Q#, Yan H#, Zhang K#, Guo X, Xu Z, Yang W, Qi Y, Guo CA, Hornsby C, Zhang L, Zhou A, Li L, Chen Y, Zhang W, Sun Y, Zheng H, Wondisford F, He L, Guo S*. Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis. Diabetes 2018 Nov;67(11):2167-2182
Fang X#, Zhang T#, Yang M, Li L, Zhang C, Hu W, Fan X, Liu H, Zhu Z, Liu D, Zheng H, Gu HF, Liu R*, Yang G*. High Circulating Alarin Levels Are Associated with Presence of Metabolic Syndrome. Cell Physiol Biochem 2018;51(5):2041-2051
Duan L#, Shen RF#, Song LY, Liao Y, Zheng HT*. A novel chimeric CYP11B2/CYP11B1 combined with a new p.L340P CYP11B1 mutation in a patient with 11OHD: case report. BMC Endocr Disord 2018 Apr 27;18(1):23
Liao X#, Song L#, Zhang L, Wang H, Tong Q, Xu J, Yang G, Yang S*, Zheng HT*. LAMP3 regulates hepatic lipid metabolism through activating PI3K/Akt pathway. Mol Cell Endocrinol 2018;470:160-167
Wang Y#, Qu H#, Xiong X, Qiu Y, Liao Y, Chen Y*, Zheng Y*, Zheng H*. Plasma Asprosin Concentrations Are Increased in Individuals with Glucose Dysregulation and Correlated with Insulin Resistance and First-Phase Insulin Secretion. Mediators Inflamm 2018 Mar 20;2018:9471583
Li X, Liao M, Shen R, Zhang L, Hu H, Wu J, Wang X, Qu H, Guo S, Long M*, Zheng H*. Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases. Mediators Inflamm 2018 Nov 6;2018:7375294
Wang Q#, Long M#, Qu H, Shen R, Zhang R, Xu J, Xiong X, Wang H, Zheng H*. DPP-4 Inhibitors as Treatments for Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis. J Diabetes Res 2018 Jan 8;2018:5308582
Duan L#*, Fang F#, Fu WL, Fang ZQ, Wang H, Yu SC, Tang ZL, Liu ZQ, Zheng HT*. Corticomedullary mixed tumour resembling a small adrenal gland-involvement of cancer stem cells: case report. BMC Endocr Disord 2017 Feb 13;17(1):9
Long M#, Li X#, Li L#, Dodson M, Zhang DD, Zheng HT*. Multifunctional p62 Effects Underlie Diverse Metabolic Diseases. Trends Endocrinol Metab 2017;28(11):818-830
Qu H#, Zheng Y#, Wang Y#, Zhang R, Ruan X, Yang G, Liu Z, Zheng HT*. Global and Regional Effects of Bladder Cancer Risk Associated with Pioglitazone Therapy in Patients with Diabetes. Sci Rep 2017;7(1):15804
Wang H#, Du L#, Wu T, Yang G, Hu W, Wang H, Yang M, Liu D, Gu HF, Zhu Z, Zheng H, Li L*. Circulating betatrophin is associated with insulin resistance in humans: cross-sectional and interventional studies in vivo and in vitro. Oncotarget 2017;8(57):96604-96614
Xu X#, Li X#, Yang G#, Li L, Hu W, Zhang L, Liu H, Zheng H, Tan M*, Zhu D*. Circulating bone morphogenetic protein-9 in relation to metabolic syndrome and insulin resistance. Sci Rep 2017 Dec 13;7(1):17529
Lei L#, Li K#, Li L#, Fang X, Zhou T, Zhang C, Luo Y, Liu H, Li X, Zheng H, Zhang L, Yang G*, Gao L*. Circulating zinc-α2-glycoprotein levels are low in newly diagnosed patients with metabolic syndrome and correlate with adiponectin. Nutr Metab (Lond) 2017 Aug 14;14:53
Su Q#, Liu C#, Zheng HT, Zhu J, Li PF, Qian L, Yang WY*. Comparison of Insulin Lispro Mix 25 with Insulin Lispro Mix 50 as Insulin Starter in Chinese Patients with Type 2 Diabetes Mellitus (CLASSIFY Study): A Subgroup Analysis of a Phase 4, Open-Label, Randomized Trial. J Diabetes 2017;9(6):575-585
Xu XH#, Lai YR#, Yang GY, Yang ML, Li L, Zhang Q, Liu H, Zheng HT, Zhu DP*. Adiponectin/(FBG × FIns) as a predictor of insulin sensitivity and metabolic syndrome in patients with polycystic ovary syndrome. Medicine (Baltimore) 2016 Dec;95(49):e5524
Chen C#, Zeng Y#, Xu J, Zheng HT, Liu J, Fan R, Zhu W, Yuan L, Qin Y, Chen S, Zhou Y, Wu Y, Wan J, Mi M*, Wang J*. Therapeutic effects of soluble dietary fiber consumption on type 2 diabetes mellitus. Exp Ther Med 2016 Aug;12(2):1232-1242
Wang H#, Liu XF#, Long M#, Huang Y#, Zhang LL, Zhang R, Zheng Y, Liao XY, Wang YR, Liao Q, Li WJ, Tang ZL, Tong Q, Wang XC, Fang F, Rojo de la Vega M, Ouyang Q, Zhang DD*, Yu SC*, Zheng HT*. NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis. Sci Transl Med 2016 Apr 13;8(334):334ra51
Recommended by F1000 Prime http://f1000.com/prime/726286483
Commented by Cell Metab 2016 Jun 14;23(6):959-960
Long M, Rojo de la Vega M, Wen Q, Bharara M, Jiang T, Zhang R, Zhou SW, Wong PK, Wondrak GT*, Zheng HT*, Zhang DD*. An essential role of NRF2 in diabetic wound healing. Diabetes 2016;65(3):780-793
Wang H, Rojo de la Vega M, Zhang DD*, Yu SC*, Zheng HT*. Response to comment on "NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis". Science Transl Med 2016;8(349):349lr1
Zheng HT. Some antioxidant antidiabetic agents may link to tumor metastasis in mice. Science Foundation in China 2016;24(3):53
Zhang JL#, Liu GK#, Ruan Y#, Wang JL#, Zhao K, Wan Y, Liu B, Zheng HT, Peng T, Wu W, He P, Hu FQ*, Jian R*. Dax1 and Nanog act in parallel to stabilize mouse embryonic stem cells and induced pluripotency. Nat Commun 2014 Oct 6;5:5042
Jiang T#*, Tian F#, Zheng HT, Whitman SA, Lin YF, Zhang ZG, Zhang N, Zhang DD*.Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-kappaB-mediated inflammatory response. Kidney Int 2014;85(2):333-343
Samantha A Whitman, Min Long, Georg Wondrak, Zheng HT*, Donna D. Zhang*. Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy. Exp Cell Res 2013;319(17):2673-2683
Tong Q#, Duan L#, Xu ZH, Wang H, Wang XC, Li ZJ, Zhang WZ, Zheng HT*. Improved Insulin Secretion Following Intrapancreatic UCB Transplantation in Patients With T2DM. J Clin Endocrinol Metab 2013;98(9):E1501-E1504
Zheng HT, Whitman SA, Wu W, Wondrak GT, Wong PK, Fang DY, Zhang DD*. Therapeutic Potential of Nrf2 Activators in Streptozotocin -Induced Diabetic Nephropathy. Diabetes 2011;60(11):3055-3066
Comments by Diabetes in the same issue Diabetes 2011 Nov;60(11):2683-2684
Liu JB, Jia L, Li BR, Lan LZ, Ge Q, Zheng HT, Deng HC*. Adiponectin suppresses inflammatory responses at the early phase of atherosclerosis in hyperglycemic rats. Mol Med Rep 2010 Mar-Apr;3(2):323-328

Chunjiu Zhong

Dr. Chunjiu Zhong received his B.S. degree in Clinical Medicine from Anhui Medical University in 1986 and M.S. degree in Neurology from (former) Shanghai Medical University in 1992. He obtained his Ph.D. degree in Neurology in 2007 from Fudan University. Since 1992, Dr. Zhong has been working at Zhongshan Hospital, Shanghai Medical University (presently Fudan University) as a clinician and researcher in Neurology. In 2009, he joined the State Key Laboratory of Medical Neurobiology and in 2010, he joined the Institutes for Brain Science as a principal investigator. He is also associate editor-in-chief of Neuroscience Bulletin, and an outstanding executive member in Chinese Neuroscience Society and Chinese Committee for Alzheimer's Disease International (ADI).

His research has been focused on pathogeneses, clinical diagnosis, prevention and treatment of neurodegenerative disorders, especially Alzheimer's disease and Parkinson's disease. Prof. Zhong proposed that Alzheimer's disease is a metabolic disorder and hypothesized that abnormal thiamine metabolism contributes to the onset and progression of Alzheimer's disease by perturbing cerebral glucose metabolism and provoking multiple pathogenic cascades. Based on this hypothesis, Prof. Zhong proposed a novel strategy for searching new targets of Alzheimer's disease diagnosis and intervention through decoding the mechanism in brain glucose hypometabolism of the disease. He first found and demonstrated the diagnostic value of detecting the levels of blood thiamine metabolites for Alzheimer's disease (coverage news in AAIC 2013, Ebiomedicine 2016). He also developed two patent chemical drugs of class I in China against Alzheimer's disease as sponsor.

SELECTED PUBLICATIONS

Zhang J, Wang L, Deng X, Fei G, Jin L, Pan X, Cai L, Albano AD, Zhong C*. Five-minute cognitive test as a new quick screening of cognitive impairment in the elderly. Aging Dis 2019 Dec 1;10(6):1258-1269
Wang L, Pan X, Fei G, Wang C, Wan W, Sang S, Wang H, Wang Z, Zhong C. Decreased function of delayed recall in non-demented elderly subjects with apolipoprotein E ε4 allele. Front Aging Neurosci 2019 Mar 29;11:71
Zhao L, Cheng X, Zhong C. Implications of successful symptomatic treatment in Parkinson's disease for therapeutic strategies of Alzheimer's disease. ACS Chem Neurosci 2019 Feb 20;10(2):922-930
Cheng X, Ma D, Fei G, Ma Z, Xiao F, Yu Q, Pan X, Zhou F, Zhao L, Zhong C. A single-step method for simultaneous quantification of thiamine and its phosphate esters in whole blood sample by ultra-performance liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2018 Sep 15;1095:103-111
Sang S, Pan X, Chen Z, Zeng F, Pan S, Liu H, Jin L, Fei G, Wang C, Ren S, Jiao F, Bao W, Zhou W, Guan Y, Zhang Y, Shi H, Wang Y, Yu X, Wang Y, Zhong C. Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer's disease, whereas amyloid deposition does not. Alzheimers Res Ther 2018;10(1):26
Liu H, Sang S, Lu Y, Wang Z, Yu X, Zhong C. Thiamine metabolism is critical for regulating correlated growth of dendrite arbors and neuronal somata. Sci Rep 2017;7(1):5342
Pan X, Fei G, Lu J, Jin L, Pan S, Chen Z, Wang C, Sang S, Liu H, Hu W, Zhang H, Wang H, Wang Z, Tan Q, Qin Y, Zhang Q, Xie X, Ji Y, Cui D, Gu X, Xu J, Yu Y, Zhong C. Measurement of blood thiamine metabolites for Alzheimer's disease diagnosis. EBioMedicine 2016;3:155-162
Zhao L, Gong N, Liu M, Pan X, Sang S, Sun X, Yu Z, Fang Q, Zhao N, Fei G, Jin L, Zhong C, Xu T. Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model. Neurobiol Aging 2014;35(12):2736-2745
Chen Z, Zhong C. Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. Prog Neurobiol 2013;108:21-43
Jin L, Wang J, Zhao L, Jin H, Fei G, Zhang Y, Zeng M, Zhong C. Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinson's disease. Brain 2011;134(Pt 1):50-58
Pan X, Gong N, Zhao J, Yu Z, Gu F, Chen J, Sun X, Zhao L, Yu M, Xu Z, Dong W, Qin Y, Fei G, Zhong C, Xu TL. Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. Brain 2010;133(Pt 5):1342-1351

Jiawei Zhou

Jiawei Zhou earned his PhD from the Imperial College, UK in 1996. He received his postdoctoral training in the Hahnemann University, USA in 1996-1998, and was then appointed as a Laboratory Head of the Shanghai Institute of Physiology, Chinese Academy of Sciences in 1998. He is currently serving as a Senior Investigator in the Institute of Neuroscience, Chinese Academy of Sciences.

His research has focused on the molecular and cellular mechanisms underlying the maintenance of immune homeostasis in the CNS and the regulation of dopaminergic neurotransmission in mammals. Specific focuses are in understanding cell signaling that regulates neuroinflammation in Parkinson's disease (Nature, 2013, Transl Neurodegener, 2019; BMC Med, 2019), as well as the molecular basis underlying modulation of dopamine signaling (Nat Neurosci, 2015). His team was the first to clone GFRAL gene (J Neurochem, 2005) which is now known as the receptor for GDF15, a crucial factor for the regulation of metabolism.

He is the recipient of several awards, including the Outstanding Youth Award (NSFC), Sanofi Neuroscience Outstanding Scholarship Award. He currently serves as the Vice President of the Chinese Association for Physiological Sciences, the Head of the Glial Cell Research Subcommittee and Deputy Head of Neurodegenerative Disease Subcommittee, Chinese Neuroscience Society. He is a member of Editorial Board of several scientific journals, such as Front Aging Neurosci (Associate Editor), ACS Chem Neurosci (Associate Editor, 2017-2019), Transl Neurodegener (Section Editor) and ASN Neuro.

In the past several years, he has been invited to give talks in a number of international conferences, such as 12th, 13th, 14th International Conference on Alzheimer's and Parkinson's Diseases, 10th IBRO World Congress of Neuroscience, 37th Annual Meeting of Australasian Society of Neuroscience, 2018 Annual Meeting of the Glia Section of the Korean Society for Brain and Neural Science, 8th Congress of International Union of Physiological Sciences, Cold Spring Harbor Asia Conferences, 13th International Congress of Neuroimmunology, 55th Annual Meeting of the Japanese Society of Neurology, etc.

SELECTED PUBLICATIONS

Zhang SZ#, Wang QQ#, Yang QQ, Gu HY, Yin YQ, Li YD, Hou JC, Chen R, Sun QQ, Sun YF, Hu G, Zhou JW*. NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis. BMC Med 2019 Nov 15;17(1):204 (#co-first author)
Lu SZ, Guo YS, Liang PZ, Zhang SZ Yin S, Yin YQ, Wang XM, Ding D, Gu XS and Zhou JW. Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation. Transl Neurodegener 2019 Jan 18;8:3
Guo YS, Liang PZ, Lu SZ, Chen R, Yin YQ, Zhou JW*. Extracellular αB-crystallin modulates the inflammatory responses. Biochem Biophys Res Commun 2019 Jan 1;508(1):282-288
Zhu SY#, Zhao CJ#, Wu YY#, Yang QQ, Shao AY, Wang TP, Wu JF, Yin YQ, Li YD, Hou JC, Zhang XH, Zhou GM, Gu XS, Wang XM, Bustelo XR, Zhou JW*. Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking. Nat Neurosci 2015 Aug;18(8):1084-1093 (#co-first author)
Yan Hu, Sen Li, Hua Jiang, Ming-Tao Li*, Jia-Wei Zhou*. Ephrin-B2/EphA4 forward signaling is required for regulation of radial migration of cortical neurons in the mouse. Neurosci Bull 2014 Jun;30(3):425-432
Shao W#, Zhang SZ#, Tang M, Zhang XH, Zhou Z, Yin YQ, Zhou QB, Liu YJ, Huang YY, Wawrousek E, Chen T, Li SB, Xu M, Zhou JN, Hu G, Zhou JW*. Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin. Nature 2013 Feb 7;494(7435):90-94 (#co-first author)
Highlighted in Nat Rev Immunol; Sci Signal; SciBX: Science-Business eXchange, F1000Prime, Nature China

Yi Zhou

M.D., Ph.D., Associate researcher, Department of Nephrology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Address: 58 Zhongshan 2nd Road, Guangzhou, 510080, China
Telephone: (86)-020-8755766 (office); 151-1209-2273 (cell)
E-mail: zhouyi39@mail.sysu.edu.cn; zhouyisysu@163.com

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2017.12-present: Associate researcher, Department of Nephrology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
2012.01-2017.12: Assistant researcher, Department of Nephrology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
2015.07-2016.10: Post-doctoral Research Fellow, Division of Infectious diseases, Boston Children’s Hospital, Harvard Medical School, Boston, MA
2011.10-2015.06: Post-doctoral Research Fellow, Cardiovascular Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
2010.07-2012.01: Resident Physician, Department of Nephrology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
2005.09-2010.06: Ph.D. Medicine, Department of Nephrology, Sun Yat-sen University, Guangzhou, China
2000.09-2005.07: Bachelor of Medicine, Department of Medicine, Tongji Medical college of Huazhong University of Sci-Tech, Wuhan, China

SELECTED PUBLICATIONS

Wang Y, Lu M, Xiong L, Fan J, Zhou Y, Li H, Peng X, Zhong Z, Wang Y, Huang F, Chen W, Yu X, Mao H. Drp1-mediated mitochondrial fission promotes renal fibroblast activation and fibrogenesis. Cell Death Dis 2020 Jan 16;11(1):29
Zhang X*, Zhou Y*, Yu X, Huang Q, Fang W, Li J, Bonventre JV, Sukhova GK, Libby P, Shi GP. Differential Roles of Cysteinyl Cathepsins in TGF-β Signaling and Tissue Fibrosis. iScience 2019 Aug 9;19:607-622 (co-first author)
Peng X, Wang Y, Li H, Fan J, Shen J, Yu X, Zhou Y, Mao H. ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury. Cell Death Dis 2019 Mar 15;10(4):253 (co-correspondence author)
Cao S, Li S, Wang Y, Shen J, Zhou Y, Li H, Yu X, Mao H. Acetylation of HMGB1 by JNK1 Signaling Promotes LPS-Induced Peritoneal Mesothelial Cells Apoptosis. BioMed Res Int 2018 Nov 12;2018:2649585
Zhou Y, Chen H, Yang M, Zhang L, Ichimura T, Liu L, Yu X, Sukhova GK, Kyttaris VC, Bonventre JV, Tsokos GC, Libby P, Stillman IE, Shi GP. CD74 Deﬁciency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice. J Immunol 2017;198(7):2568-2577
Zhou Y, Chen H, Liu L, Yu XQ, Sukhova GK, Yang M, Kyttaris V, Stillman I, Libby P, Tsokos G, Shi GP. Cathepsin K deficiency suppresses autoimmunity and nephritis by inhibiting Toll-like receptor-7 activation and enhancing regulatory T cell function. J Immunol 2017;198(5):1846-1854
Zhou Y, Cao S, Li H, Peng X, Wang Y, Fan J, Wang Y, Zhuang S, Yu X, Mao H. Heat Shock Protein 72 Antagonizes STAT3 Signaling to Inhibit Fibroblast Accumulation in Renal Fibrogenesis. Am J Pathol 2016;186(4):816-828
Liu CL, Wang Y, Liao M, Wemmelund H, Ren J, Fernandes C, Zhou Y, Sukhova GK, Lindholt JS, Johnsen SP, Zhang JY, Cheng X, Huang X, Daugherty A, Levy BD, Libby P, Shi GP. Allergic Lung Inflammation Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysms in Mice. Arterioscler Thromb Vasc Biol 2016;36(1):69-77
Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, Zhou Y, Sukhova GK, Chen H, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, Jiang M, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, Jarolim P, Libby P, Shi GP*. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med 2015;21(7):820-826
Zhou Y, Yu X, Chen H, Sjöberg S, Roux J, Zhang L, Ivoulsou AH, Bensaid F, Liu CL, Liu J, Tordjman J, Clement K, Lee CH, Hotamisligil GS, Libby P, Shi GP. Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages. Cell Metab 2015;22(6):1045-1058
Zhou Y, Wu W, Lindholt JS, Sukhova GK, Libby P, Yu X, Shi GP. Regulatory T cells in human and angiotensin II-induced mouse abdominal aortic aneurysms. Cardiovasc Res 2015;107(1):98-107
Chen G, Wang X, Severo MS, Sakhon OS, Sohail M, Brown LJ, Sircar M, Snyder GA, Sundberg EJ, Ulland TK, Olivier AK, Andersen JF, Zhou Y, Shi GP, Sutterwala FS, Kotsyfakis M, Pedra JH. The tick salivary protein sialostatin L2 inhibits caspase-1-mediated inflammation during Anaplasma phagocytophilum infection. Infect Immun 2014;82(6):2553-2564
Cao S, Li S, Li H, Xiong L, Zhou Y, Fan J, Yu X, Mao H. The potential role of HMGB1 release in peritoneal dialysis-related peritonitis. PLoS One 2013;8(1):e54647
Cao X, Yang Q, Qin J, Zhao S, Li X, Fan J, Chen W, Zhou Y, Mao H, Yu X. V-ATPase promotes transforming growth factor-β-induced epithelial-mesenchymal transition of rat proximal tubular epithelial cells. Am J Physiol Renal Physiol 2012;302(9):F1121-1132
Li S*, Zhou Y*, Fan J, Cao S, Cao T, Huang F, Zhuang S, Wang Y, Yu X, Mao H. Heat shock protein 72 enhances autophagy as a protective mechanism in lipopolysaccharide-induced peritonitis in rats. Am J Pathol 2011;179(6):2822-2834 (co-first author)
Zhou Y, Mao H, Li S, Cao S, Li Z, Zhuang S, Fan J, Dong X, Borkan SC, Wang Y, Yu X. Hsp72 Inhibits Smad3 Activation and Nuclear Translocation in Renal Epithelial-to-Mesenchymal Transition. J Am Soc Nephrol 2010;21:598–609

Jinxia Zhu

Professor in Department of Physiology and Pathophysiology, School of Basic Medical Science, Capital Medical University, Beijing, China
Address: No.10 Xitoutiao, You An Men, Beijing 100069, China
Telephone: 86-10-83950493(Office); 86-10-13693279817
E-mail: zhu_jx@ccmu.edu.cn

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
2004-present: Professor (Department Chair 2005-2015), Department of Physiology, School of Basic Medical Science, Capital Medical University, Beijing, China
2000-2001: Visiting Scholar, Epithelial Cell Biology Research Center, CUHK, Hong Kang, China
1996-1999: Visiting Scholar/Postdoc, Department of Internal Medicine, Gastrointestinal Peptide Research Center, University of Michigan, Ann Arbor, USA
1996-2004: Professor, Department of Physiology, Henan Medical University, Henan, China
1983-1996: Assistant, Lecturer, Associate Professor Department of Physiology, Henan Medical University, Henan, China
2001-2004: Ph.D., Department of Physiology, CUHK (Chinese University of Hong Kong, Hong Kong, China
1984-1987: M.Sc., Department of Anatomy, Henan Medical University, China
1978-1982: M.D., Henan Medical University, China

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS
2017-2022: Chairman, Committee on digestion and nutrition, CAPS
2015-2017: Chairman designate, Committee on digestion and nutrition, CAPS
2019-2024: Vice Chairman, Committee on Neurogastroenterology, CRHA
2019-2023: Acta Physiologica Sinica, Associate editor
2019-2022: Council Member, Beijing Cognitive Neuroscience Society
2010-2022: Vice Chairman, Chinese Association for GI-Endocrine Physiology
2010-present: Council Member, Chinese Association for Physiological Sciences
2010-present: Member, American Neurogastroenterology and Motility Society
2009-present: Member, America Gastroenterological Association
Peer Reviewer in Journal of Physiology，British Journal of Pharmacology, American Journal of Gastroenterology, PLoS one, Acta Physiologica, Journal of Hepato-Gastroenterol, Journal of Physiological Sciences, Cell Biology International, Acta Physiologica Sinica, ect.

SELECTED PUBLICATIONS

Xiu XL, Zheng LF, Liu XY, Fan YY, Zhu JX*. Gastric smooth muscle cells manifest an abnormal phenotype in Parkinson's disease rats with gastric dysmotility. Cell Tissue Res 2020 Aug;381(2):217-227
Zheng LF, Ji T, Guo ZH, Wang T, Xiu XL, Liu XY, Li SC, Sun L, Xue H, Zhang Y, Zhu JX*. Na+-K+-2Cl- cotransporter 2 located in the human and murine gastric mucosa is involved in secretagogue-induced gastric acid secretion and is downregulated in lipopolysaccharide-treated mice. Eur J Pharmacol 2020 Aug 5;880:173162
Zhou Li, Ran XR, Hong F, Li GW. Zhu JX*. Downregulated dopamine receptor 2 and upregulated corticotrophin releasing hormone in the paraventricular nucleus are correlated with decreased glucose tolerance in rats with bilateral substantia nigra lesions. Front Neurosci 2019 Jul 23;13:751
Li Y, Zhang XL, Zhang Y, Feng XY, Liu CZ, Zhang XN, Zhu JX*. Dopamine Promotes Colonic Mucus Secretion through Dopamine D5 Receptor in Rats. AJP-Cell Physiology 2019 Mar 1;316(3):C393-C403
Liu CZ, Zhang XL, Zhou L, Wang T, Quan ZS, Zhang Y, Li J, Li GW, Zheng LF, Li LS, Zhu JX*. Rasagiline, an inhibitor of MAO-B, decreases colonic motility through elevating colonic dopamine content. Neurogastroenterol Motil 2018 Nov;30(11):e13390
Feng XY, Zhang DN, Wang YA, Fan RF, Hong F, Zhang Y, Li Y*, Zhu JX*. Dopamine enhances duodenal epithelial permeability via the dopamine D5 receptor in rodent. ACTA Physiologica (Oxf). 2017 May;220(1):113-123
Zhang XL, Li Y, Liu CZ, Fan RF, Wang P, Zheng LF, Hong F, Feng XY, Zhang Y, Li LS, Zhu JX*. Alteration of enteric monoamines with monoamine receptors and colonic dysmotility in 6-OHDA-induced Parkinson’s disease rats. Transl Res 2015;166:152-162
Y Chen, F Hong(Co-first author), H Chen, RF Fan, XL Zhang, Y Zhang, JX Zhu*. Distinctive expression and cellular distribution of dopamine receptors in the pancreatic islets of rats. Cell Tissue Res 2014 Sep;357(3):597-606
J Song, LF Zheng, XL Zhang, XY Feng, RF Fan, L Sun, Y Zhang, JX Zhu*. Upregulation of β1-adrenoceptors is involved in the formation of gastric dysmotility in the 6-OHDA rat model of Parkinson's disease. Transl Res 2014;164:22–31
Hong F, Liu L, Fan RF, Chen Y, Chen H, Zheng RP, Zhang Y, Jing P, GaoY, Zhu JX*. New Perspectives of VMAT2 Chemical Characteristics in Mammals and Its Constant Expression in Type1 Diabetes Rat Models. Transl Res 2014 Feb;163(2):171-182
Zheng LF, Song J, Fan RF, Chen CL, Zhang XL, Feng XY, Zhang Y, Li LS, Zhu JX*. The role of vagal pathway and gastric dopamine in the gastroparesis of rats after 6-hydroxydopamine microinjection in the substantia nigra. ACTA Physiol (Oxf) 2014 June;211(2):434–446
Cited in
RF Pfeiffer*. Gastrointestinal involvement in Parkinson’s disease: the horse or the cart (Editorial). Acta Physiol (Oxf) 2014 Jun;211(2):271-272
(This model has been written in “Critical Evaluation of Animal Models of Gastrointestinal Disorders” Chapter in Handb Exp Pharmacol 2017;239:289-317)
Ye Chen, Feng Hong(Co-first author), Hui Chen, Ruifang Fan, Xiaoli Zhang, Yue Zhang, Zhu JX*. Distinctive expression and cellular distribution of dopamine receptors in the pancreatic islets of rats. Cell Tissue Res 2014 Sep;357(3):597-606
Feng XY, Li Y, Li LS, Li XF, Zheng LF, Zhang XL, Fan RF, Song J, Hong F, Zhang Y, Zhu JX*. Dopamine D1 receptors mediate dopamine-induced duodenal epithelial ion transport in rats. Transl Res 2013;161(6):486-494
Xu JD, Liu S(Co-first author), Wang W, Li LS, Li XF, Li Y, Guo H, Ji T, Feng XY, Hou XL, Zhang Y, Z Zhu JX*. Emodin induces chloride secretion in rat distal colon through activation of mast cells and enteric neurons. Br J Pharmacol 2012;165:197–207
Ji T, Liu SM, Zheng LF, Wang Q, Dou ZF, Zhang Y, Zhu JX*. Cellular distribution of NKCC2 in the gastric mucosa and its response to short-term osmotic shock. Cell Tissue Res 2012;348(1):155-165
Yang N, SM Liu, LF Zheng, T Ji, Y Li, XL Mi, H Xue, W Ren, JD Xu, XH Zhang, LS Li, Y Zhang, Zhu JX. Activation of Submucosal 5-HT3 Receptor Elicits a Somatostatin- dependent Inhibition of Rat Colonic Secretion. Br J Pharmacol 2010;159:1623-1635

Jingning Zhu

Ph.D., Professor, School of Life Sciences, Nanjing University
Address: 163 Xianlin Avenue, Nanjing, 210023 China

EDUCATION BACKGROUND AND ACADEMIC EXPERIENCE
Vice Dean School of Life Sciences, Nanjing University 2019-
Head of Department of Physiology School of Life Sciences, Nanjing University 2017-2019
Professor School of Life Sciences, Nanjing University 2012-
Associate Professor School of Life Sciences, Nanjing University 2007-2012
Lecturer School of Life Sciences, Nanjing University 2006-2007
Ph.D Nanjing University Physiology 2006
B.S Nanjing Normal University Biological Science 2001

HONORS, PRIZES AND AWARDS
Award by IBRO Alumni Committee 2010
Outstanding Doctoral Dissertation Award by Jiangsu Province , China 2007
Third Prize, Outstanding Paper Award for National Young Physiological Scientists
by Xi-Jun Zhang Foundation, Chinese Association of Physiological Sciences 2006

MEMBERSHIP IN PROFESSIONAL SOCIETIES / COMMITTEES / EDITORIAL BOARDS

Receiving Editor Acta Physiologica Sinica
Editorial board member Cerebellum and Ataxias
Guest Associate Editor Frontiers in Cellular Neuroscience
Standing Council Member Chinese Association of Physiological Sciences
Vice Director of Youth Working Committee Chinese Association of Physiological Sciences
Member of Committee of Comparative Physiology Chinese Association of Physiological Sciences
Council Member The Chinese Neuroscience Society
Vice Director of Sensory and Motor Branch The Chinese Neuroscience Society
Member of Youth Working Committee The Chinese Neuroscience Society
President Jiangsu Provincial Society for Physiological Sciences
Standing Council Member Jiangsu Provincial Society for Neuroscience
International Delegate Society for Research on the Cerebellum and Ataxias
Member Society for Neuroscience

SELECTED PUBLICATIONS

Ji MJ, Zhang XY, Chen Z, Wang JJ*, Zhu JN*. (2019) Orexin prevents depressive-like behavior by promoting stress resilience. Molecular Psychiatry 24(2):282-293
Image: Ji MJ, Zhang XY, Chen Z, Wang JJ*, Zhu JN*. (2019) Two orexin receptors, OX1R and OX2R, are expressed and co-localized in the ventral pallidal neurons. Molecular Psychiatry 24:161
Chen ZP, Zhang XY, Peng SY, Yang ZQ, Wang YB, Zhang YX, Chen X, Wang JJ*, Zhu JN*. (2019) Histamine H1 receptor contributes to vestibular compensation. Journal of Neuroscience 39(3):420-433
Zhuang QX, Li GY, Li B, Zhang CZ, Zhang XY, Xi K, Li HZ, Wang JJ*, Zhu JN*. (2018) Regularizing firing patterns of rat subthalamic neurons ameliorates parkinsonian motor deficits. Journal of Clinical Investigation 128(12):5413-5427
Commentary by Whalen TC, Gittis AH. (2018) Histamine and deep brain stimulation: the pharmacology of regularizing a brain. Journal of Clinical Investigation 128(12):5201-5202
JCI Research Editor’s Picks: Normalizing subthalamic nucleus neuronal firing pattern improves parkinsonian motor impairment. JCI This Month 2018, 12:2
Wang Y, Chen ZP, Zhuang QX, Zhang XY, Li HZ, Wang JJ*, Zhu JN*. (2017) Role of corticotropin-releasing factor in cerebellar motor control and ataxia. Current Biology 27(17):2661-2669
Dispatched by Manto M. (2017) Motor control: CRF regulates coordination and gait. Current Biology 27(17):R847-R850
Zhang J, Li B, Yu L, He YC, Li HZ, Zhu JN*, Wang JJ*. (2011) A role for orexin in central vestibular motor control. Neuron 69(4):793-804
Previewed by Gao XB, Horvath TL. (2011) An arousing discovery on catalepsy: orexin regulates vestibular motor functions. Neuron 69(4):588-590

REVIEWS

Li GY, Zhuang QX, Li B, Wang JJ*, Zhu JN*. (2017) Subthalamic nucleus: from circuits, functions to a deep brain stimulation target for the treatment of Parkinson's disease. Acta Physiologica Sinica 69(5):611-622 (in Chinese)
Zhang XY, Wang JJ*, Zhu JN*. (2016) Cerebellar fastigial nucleus: from anatomic construction to physiological functions. Cerebellum Ataxias 3:9
Li B, Zhu JN*, Wang JJ. (2014) Histaminergic afferent system in the cerebellum: structure and function. Cerebellum Ataxias 1:5
He YY, Zhang XY, Yung WH, Zhu JN*, Wang JJ*. (2013) Role of BDNF in central motor structures and motor diseases. Molecular Neurobiology 48(3):783-793
Zhang XY, Yu L, Zhuang QX, Zhu JN*, Wang JJ*. (2013) Central functions of the orexinergic system. Neuroscience Bulletin 29(3):355-365 (Cover Story)

BOOK CHAPTERS

Zhu JN, Wang JJ (2014) Central mechanisms underlying the coordination and integration of somatic motor and nonsomatic responses. In: Progresses in Physiological Sciences. Wang JJ and Wang XM (eds). Higher Education Press, Beijing. pp. 684-694 (in Chinese)
Wang JJ, Zhu JN (2013) Movement and its central control. In: Neurobiology, 3rd edition. Shou TD (eds). Higher Education 4 Press, Beijing. pp. 245-300 (in Chinese)

Minghui Zou

Ming-Hui Zou, an internationally recognized researcher in molecular and translational medicine and a Georgia Research Alliance Eminent Scholar in Molecular Medicine and associate vice president for research at Georgia State University, is the founding director of the Center for Molecular and Translational Medicine at Georgia State.

He holds a doctorate and medical degree and has received prestigious awards from the Juvenile Diabetes Foundation International and the American Heart Association, including the Career Development Award, Irvin H. Page Atherosclerosis Research Award, and National Established Investigator Award.

Zou studies the role of oxidative stress in cardiovascular biology and diseases. He is recognized for making influential discoveries in cardiovascular research, including identifying the role of two key proteins involved in the vessel pathology that leads to vascular diseases and characterizing the AMP-activated kinase (AMPK), a key enzyme in the regulation of energy metabolism, obesity, diabetes, and cardiovascular diseases, as a sensor and regulator of oxidative stress in cardio-metabolic syndromes.

An independent investigator of the National Institutes of Health, the Juvenile Diabetes Research Foundation International (JDRF), and the American Diabetes Association, and a National Scientist Development (SDG) and National Established Investigator (EIA) awardee of the American Heart Association, Zou has used these (and many other awards) to make scientific observations in fields with great potential for immediate clinical relevance.

In the last three years, he has published over 135 peer reviewed papers in highly impacted journals including Nature Medicine, J. Clin. Invest., Circulation., Circulation Research, ATVB, Diabetes, J. Biol. Chem., Hypertension, etc. In 2008, he was elected to the American Society for Clinical Investigation, one of the United States’ oldest honor societies of physician-scientists, membership in which reflects accomplishments by its members at an early stage (under age 45 years old) in their careers.

SELECTED PUBLICATIONS

Wu S, Lu Q, Ding Y, Wu Y, Qiu Y, Wang P, Mao X, Huang K, Xie Z, Zou MH. Hyperglycemia-driven inhibition of AMP-activated protein kinase α2 induces diabetic cardiomyopathy by promoting mitochondria-associated endoplasmic reticulum membranes in vivo. Circulation. 2019 Apr 16;139(16):1913-1936
Han Y, Bedarida T, Ding Y, Somba BK, Lu Q, Wang Q, Song P, Zou MH. β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4. Mol Cell. 2018 Sep 20;71(6):1064-1078
Liu Z, Zhu H, Dai X, Wang C, Ding Y, Song P, Zou MH. Macrophage liver kinase B1 inhibits foam cell formation and atherosclerosis. Circ Res. 2017 Oct 13;121(9):1047-1057
Wang X, Wu W, Zhang W, Leland Booth J, Duggan ES, Tian L, More S, Zhao YD, Sawh RN, Liu L, Zou MH, Metcalf JP. RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection. Respir Res. 2017 Sep 2;18(1):166
Wu S, Lu Q, Wang Q, Ding Y, Ma Z, Mao X, Huang K, Xie Z, Zou MH. Binding of FUNDC1 with inositol 1,4,5-trisphosphate receptor in mitochondria-associated endoplasmic reticulum (ER) membranes maintains mitochondrial dynamics and function in hearts in vivo. Circulation. 2017 Dec 5;136(23):2248-2266
Wang Q, Ding Y, Song P, Zhu H, Okon I, Ding NY, Chen H, Liu D, Zou MH. Tryptophan-derived 3-hydroxyanthranilic acid contributes to angiotensin II-induced abdominal aortic aneurysm formation in mice in vivo. Circulation. 2017 Dec 5;136(23):2271-2283
Cai Z, Ding Y, Zhang M, Lu Q, Wu S, Zhu H, Song P, Zou MH. Ablation of Adenosine Monophosphate-activated Protein Kinase α1 in Vascular Smooth Muscle Cells Promotes Diet-Induced Atherosclerotic Calcification in vivo. Circ Res. 2016 Jul 22;119(3):422-433
Ding Y, Zhang M, Zhang W, Lu Q, Cai Z, Song P, Okon IS, Xiao L, Zou MH. AMP-activated protein kinase alpha 2 deletion induces VSMC phenotypic switching and promotes atherosclerotic plaque instability. Circ Res. 2016 Sep 2;119(6):718-730
Dai X, Ding Y, Liu Z, Zhang W, Zou MH. Phosphorylation of C/EBP Homologous Protein (CHOP) by the AMP-Activated Protein Kinase Alpha 1 in Macrophages Promotes CHOP Degradation and Reduces Injury-Induced Neointimal Disruption In Vivo. Circ Res. 2016 Oct 28;119(10):1089-1100
Wu Y, Song P, Zhang W, Liu J, Dai X, Liu Z, Lu Q, Ouyang C, Xie Z, Zhao Z, Zhuo X, Viollet B, Foretz M, Wu J, Yuan ZY, Zou MH. Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo. Nat Med. 2015 Apr;21(4):373-382

ISSN 0371-0874, CN 31-1352/Q

Started in 1927

Submit your article

Supplemental Data

Related Links

Editorial Board