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The role of selenoproteins in adipose tissue and obesity

ZHAO Yun-Fei, SUN Yu-Hang, JIN Tai-Hua, LIU Yue, CHEN Yang-Di, XU Wan, GAO Qian^*

College of Agriculture and Forestry, Linyi University, Linyi 276000, China

Abstract

Selenoproteins, as the active form of selenium, play an important role in various physiological and pathological processes, such as anti-oxidation, anti-tumor, immune response, metabolic regulation, reproduction and aging. Although the expression level of selenoproteins in adipose tissue is significantly influenced by dietary selenium intake, it is closely related to the homeostasis of adipose tissue. In this review, we summarized the role of selenoproteins in the physiological function of adipose tissue and the pathogenesis of obesity in recent years, in order to provide a rationale for developing potential therapeutic agents for the treatment of obesity and related metabolic diseases.

Key words: selenoproteins; adipogenesis; lipid metabolism; obesity

Received: 　　Accepted:

Corresponding author: 高倩　　E-mail:

DOI: 10.13294/j.aps.2025.0082

Citing This Article：

ZHAO Yun-Fei, SUN Yu-Hang, JIN Tai-Hua, LIU Yue, CHEN Yang-Di, XU Wan, GAO Qian. The role of selenoproteins in adipose tissue and obesity. Acta Physiol Sin 2025; 77 (5): 939-955 (in Chinese with English abstract).