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Research progress of the interaction between RAAS and clock genes in cardiovascular diseases

MA Rui-Ling¹, WANG Yi-Yuan¹, KOU Yu-Shun¹, SHEN Lu-Fan¹, WANG Hong¹, ZHANG Ling-Na¹, TIAN Jiao¹, YI Lin^1,2,*

¹College of Integrated Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China；²Gansu Provincial Key Laboratory of TCM Prevention and Treatment of Chronic Diseases, Lanzhou 730000, China

Abstract

The renin-angiotensin-aldosterone system (RAAS) is crucial for regulating blood pressure and maintaining fluid balance, while clock genes are essential for sustaining biological rhythms and regulating metabolism. There exists a complex interplay between RAAS and clock genes that may significantly contribute to the development of various cardiovascular and metabolic diseases. Although current literature has identified correlations between these two systems, the specific mechanisms of their interaction remain unclear. Moreover, the interaction patterns under different physiological and pathological conditions need further investigation. This review summarizes the synergistic roles of the RAAS and clock genes in cardiovascular diseases, explores their molecular mechanisms and pathophysiological connections, discusses the application of chronotherapy, and highlights potential future research directions, aiming to provide novel insights for the prevention and treatment of related diseases.

Key words: renin-angiotensin-aldosterone system; clock genes; biological rhythms; cardiovascular diseases

Received: 　　Accepted:

Corresponding author: 伊琳　　E-mail:

DOI: 10.13294/j.aps.2025.0064

Citing This Article：

MA Rui-Ling, WANG Yi-Yuan, KOU Yu-Shun, SHEN Lu-Fan, WANG Hong, ZHANG Ling-Na, TIAN Jiao, YI Lin. Research progress of the interaction between RAAS and clock genes in cardiovascular diseases. Acta Physiol Sin 2025; 77 (4): 669-677 (in Chinese with English abstract).