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Mechanisms of mitochondrial dynamics in ischemic stroke and therapeutic strategies

ZHENG Xin-Yue¹, ZHANG Ming^2,*, SU Kai-Qi², DING Zhi-Min¹

¹Rehabilitation Medicine College, Henan University of Chinese Medicine, Zhengzhou 450046, China；²The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China

Abstract

As a common neurological disease in China, stroke has an extremely high rate of death and disability, of which 80% is ischemic stroke (IS), causing a serious burden to individuals and society. Neuronal death is an important factor in the pathogenesis of stroke. Studies have shown that mitochondrial dynamics, as a key mechanism regulating intracellular energy metabolism and cell death, plays an important role in the pathogenesis of IS. In recent years, targeting mitochondrial dynamics has become an emerging therapeutic tool to improve neurological impairment after stroke. This paper reviews the research advance in recent years in IS mitochondrial dynamics, summarizing and discussing the overview of mitochondrial dynamics, the role of mitochondrial dynamics in IS, and the studies on mitochondrial dynamics-based treatment of IS. This paper helps to explore the mechanism of the role of mitochondrial dynamics in IS and effective interventions, and provides a theoretical strategy for targeting mitochondrial dynamics to treat IS in the clinic.

Key words: mitochondrial dynamics; mitochondrial fission, fusion; stroke

Received: 　　Accepted:

Corresponding author: 张铭　　E-mail:

DOI: 10.13294/j.aps.2025.0003

Citing This Article：

ZHENG Xin-Yue, ZHANG Ming, SU Kai-Qi, DING Zhi-Min. Mechanisms of mitochondrial dynamics in ischemic stroke and therapeutic strategies. Acta Physiol Sin 2025; 77 (3): 523-533 (in Chinese with English abstract).