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Roles and mechanisms of TRIM family proteins in the regulation of bone metabolism

YANG Jing¹, HUANG Rui-Qi¹, XU Ke¹, YANG Mian-Mian¹, YI Xue-Jie^1,2,*, CHANG Bo³, YAO Ting-Ting¹

¹College of Exercise and Health, Shenyang Sport University, Shenyang 110102, China；²Sports Social Science Research Center, Shenyang Sport University, Shenyang 110102, China；³College of Sports Science, Zhuhai College of Science and Technology, Zhuhai 519041, China

Abstract

Tripartite motif-containing (TRIM) family proteins are crucial E3 ubiquitin ligases that have garnered significant attention for their regulatory roles in bone metabolism in recent years. This article reviews the function and regulatory mechanisms of TRIM family proteins in bone metabolism, focusing on their dual roles in bone formation and resorption. It also provides a detailed analysis of signaling pathways and molecular mechanisms by which TRIM family members regulate the activities of osteoblasts and osteoclasts. Research findings suggest that modulating the expression or activity of TRIM family proteins could be beneficial for treating bone diseases such as osteoporosis. This review highlights the molecular mechanisms of TRIM family members in bone physiology and pathology, aiming to provide theoretical basis and scientific guidance for developing novel therapeutic strategies for bone diseases.

Key words: bone metabolism; TRIM family proteins; bone formation; bone resorption; bone diseases

Received: 　　Accepted:

Corresponding author: 衣雪洁　　E-mail:

DOI: 10.13294/j.aps.2025.0027

Citing This Article：

YANG Jing, HUANG Rui-Qi, XU Ke, YANG Mian-Mian, YI Xue-Jie, CHANG Bo, YAO Ting-Ting. Roles and mechanisms of TRIM family proteins in the regulation of bone metabolism. Acta Physiol Sin 2025; 77 (3): 472-482 (in Chinese with English abstract).