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Research progress on anti-aging effects of β-nicotinamide mononucleotide (NMN)

HAN Miao, HUA Jin-Lian^*

College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Northwest A&F University, Yangling 712100, China

Abstract

β-Nicotinamide mononucleotide (NMN), as the precursor of nicotinamide adenine dinucleotide (NAD), plays an important role in enhancing NAD levels. Intake of NMN can alter the composition and vitality of gut microbiota, restore mitochondrial function, inhibit inflammatory pathways, improve metabolism, counteract oxidative stress, and alleviate inflammation. NMN significantly improves recovery from aging-related diseases, such as diminished heart function, reduced fertility, memory decline, and diabetes. NMN demonstrates both efficacy and safety in anti-aging. The use of NMN in China has gradually gained acceptance, highlighting the importance of exploring the mechanism of NMN in anti-aging effects and improving the biosynthesis of NMN. In addition, NMN in combination with stem cells hold promise in the treatment of aging-related degenerative diseases and promote overall human and animal health.

Key words: β-nicotinamide mononucleotide (NMN); aging; stem cell

Received: 　　Accepted:

Corresponding author: 华进联　　E-mail:

Citing This Article：

HAN Miao, HUA Jin-Lian. Research progress on anti-aging effects of β-nicotinamide mononucleotide (NMN). Acta Physiol Sin 2024; 76 (6): 1032-1042 (in Chinese with English abstract).