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Research progress of fetuin-B in the female reproductive system

WANG Xiao¹, LYU Hong-Yan², CHEN De-Quan³, CHANG Bo⁴, YAO Ting-Ting^1,*

¹School of Exercise and Health, Shenyang Sport University, Shenyang 110102, China；²School of Physical Education, Liaoning Normal University, Dalian 116029, China；³School of Physical Education, Minnan Normal University, Zhangzhou 363000, China；⁴School of Sports Science, Zhuhai College of Science and Technology, Zhuhai 519041, China

Abstract

Fetuin-B (FETUB) is a glycoprotein mainly synthesized and secreted by the liver. It is involved in many physiological and pathological processes including glucose metabolism, inflammatory response, nonalcoholic fatty liver disease, myocardial infarction, tumor and so on. In recent years, FETUB has also been confirmed to play roles in the female reproductive system. FETUB may affect follicular development and play an important role in in vivo and in vitro fertilization. In addition, serum FETUB level is elevated significantly during pregnancy and labor. FETUB expression is changed in a variety of reproductive diseases (polycystic ovary syndrome, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy). In this review, we summarize FETUB related studies in female reproduction, and focus on the roles of FETUB in female reproductive physiology and pathology, in order to provide information for the pathogenesis of reproductive disorders.

Key words: female reproduction; fetuin-B; polycystic ovary syndrome; gestational diabetes mellitus

Received: 　　Accepted:

Corresponding author: 姚婷婷　　E-mail:

Citing This Article：

WANG Xiao, LYU Hong-Yan, CHEN De-Quan, CHANG Bo, YAO Ting-Ting. Research progress of fetuin-B in the female reproductive system. Acta Physiol Sin 2024; 76 (6): 1019-1031 (in Chinese with English abstract).