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Revisiting the vasopressin V2 receptor

LI Meng^1,2, WANG Wei-Dong², LI Chun-Ling^1,*

¹Department of Physiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China；²Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China

Abstract

Arginine vasopressin (AVP) plays a crucial role in various physiological processes including water reabsorption, cardiovascular homeostasis, hormone secretion, and social behavior. AVP acts through three distinct receptor subtypes, i.e., V1a, V1b, and V2. Among them, the vasopressin V2 receptor (V2R) was initially discovered in the principal cells of renal collecting ducts, where it is primarily involved in regulating water reabsorption. However, in recent years, with the advancement of imaging and bioinformatics techniques, there has been a deeper understanding of the microstructure, protein binding capacity, and specific tissue distribution of V2R. Additionally, the pathogenic roles and target effects of V2R in various diseases have been uncovered through ectopic overexpression, activation, or antagonism. This paper aims to provide a brief overview of current research status on the physiological functions, pathophysiological mechanisms, and drug development related to V2R in recent years.

Key words: arginine vasopressin; vasopressin V2 receptor; vasopressin resistance; cyclic adenosine monophosphate

Received: 　　Accepted:

Corresponding author: 李春凌　　E-mail:

Citing This Article：

LI Meng, WANG Wei-Dong, LI Chun-Ling. Revisiting the vasopressin V2 receptor. Acta Physiol Sin 2024; 76 (6): 893-907 (in Chinese with English abstract).