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The landscape of GPCR in the skin epidermal stem cells: From the basic to the clinical

ZHANG Zhi-Lin¹, MA Xiao-Qing¹, ZHANG Zhao-Tian¹, ZHANG Rong-Hao¹, CUI Ru-Tao^2,*

¹The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310058, China；²Skin Disease Research Institute, the Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310058, China

Abstract

Skin, as the body's largest organ, acts as the primary defense mechanism against infection and injury. The maintenance of skin health heavily relies on the regulation of epidermal stem cells, crucial for ensuring epidermal homeostasis, hair regeneration, and the repair of epidermal injuries. Recent studies have placed a growing emphasis on G protein-coupled receptor (GPCR) in the context of understanding epidermal stem cells, uncovering its significant role in determining their fate. The activation of GPCR triggers the subsequent dissociation of the βγ subunits from the α subunit of G protein, leading to the modulation of various downstream signaling pathways, such as the WNT-BMP signaling crosstalk and the Gαs-PKA signaling pathway. These pathways collectively influence the fate of epidermal stem cells. Consequently, targeted GPCR therapy has emerged as a promising strategy for improving skin health by orchestrating the fate of epidermal stem cells, unveiling potential therapeutic targets that demand further investigation.

Key words: G protein-coupled receptor; skin; epidermal stem cells Review This

Received: 　　Accepted:

Corresponding author: 崔儒涛　　E-mail:

Citing This Article：

ZHANG Zhi-Lin, MA Xiao-Qing, ZHANG Zhao-Tian, ZHANG Rong-Hao, CUI Ru-Tao. The landscape of GPCR in the skin epidermal stem cells: From the basic to the clinical. Acta Physiol Sin 2024; 76 (6): 881-892