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m⁶A RNA methylation is a potential biological target for neuropathic pain

ZHANG Yu-Ting, ZHANG Li-Cai^*

Jiangsu Provincial Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, China

Abstract

N6-methyladenosine (m⁶A) is the most common type of RNA modification in eukaryotes, which affects intracellular RNA metabolism and controls gene expression of related pathophysiological processes through dynamic reversible regulation of methyltransferases, demethylases and m⁶A-binding proteins. In recent years, the involvement of m6A methylation in the study of neuropathic pain has become a hot topic, some new understandings have been emerging, and m⁶A methylation has become a potential biological target for the treatment of neuropathic pain. Therefore, this article reviews the role and regulation of m⁶A methylation in neuropathic pain, in order to provide new enlightenment for the drug development and treatment of neuropathic pain.

Key words: N6-methyladenosine; methyltransferases; demethylases; m6A-binding protein; neuropathic pain

Received: 　　Accepted:

Corresponding author: 张励才　　E-mail:

Citing This Article：

ZHANG Yu-Ting, ZHANG Li-Cai. m⁶A RNA methylation is a potential biological target for neuropathic pain. Acta Physiol Sin 2024; 76 (5): 809-817 (in Chinese with English abstract).