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Research progress of human induced pluripotent stem cells in the establishment and application of dilated cardiomyopathy disease model 

XIE Man-Ting, XIE Bing-Bing, XIANG Qiu-Ling^*

Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China

Abstract

Dilated cardiomyopathy (DCM) is a non-ischemic cardiomyopathy with abnormal myocardial structure and function. It is challenging to construct human primary cardiac myocytes from DCM patients due to ethical constraints. In addition, animal models failed to adequately replicate the complexity of the human disease. The mechanism of DCM remains unclear. The emergence of human induced pluripotent stem cells (hiPSCs) provides a new tool for basic research in DCM. Researchers have produced hiPSCs-derived cardiomyocytes (hiPSC-CMs) and applied them to drug screening, leading to new insight into the pathomechanism and treatment in DCM. This review summarizes the research progress in the establishment, drug screening and mechanism research of DCM patient-specific hiPSC-CMs (DCM-hiPSC-CMs) model.

Key words: dilated cardiomyopathy; induced pluripotent stem cells; disease model; research progress

Received: 　　Accepted:

Corresponding author: 向秋玲　　E-mail:

Citing This Article：

XIE Man-Ting, XIE Bing-Bing, XIANG Qiu-Ling. Research progress of human induced pluripotent stem cells in the establishment and application of dilated cardiomyopathy disease model . Acta Physiol Sin 2024; 76 (5): 775-782 (in Chinese with English abstract).