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The prognostic significance and therapeutic prospects of bilirubin in tumors

FU Wen, CHEN Xin, XU Wen-Wen, LIU Jin-Bao^*

Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Department of Pathophysiology, School of Basic Medicine, Guangzhou Medical University, Guangzhou 511436, China

Abstract

Tumors pose a significant global health concern and have long been a challenging issue in the medical field. Given its treatment dilemma, it is urgent to explore novel prevention and treatment strategies. Bilirubin, as a natural endogenous antioxidant, has the ability to inhibit the production of free radicals in the body, thereby alleviating the damage caused by oxidative stress to the organism. In recent years, the therapeutic effects of bilirubin in diseases mediated by oxidative stress and metabolic disorders have gradually gained widespread attention, demonstrating its potential therapeutic value for a variety of diseases. With further research, significant progress has also been made in the study of bilirubin in the field of oncology, suggesting its potential important role in the occurrence, development, and treatment of tumors. This article aims to review and summarize the recent advances in the study of bilirubin in the field of oncology, in order to provide new insights and guidance for the future directions of tumor diagnosis, prevention, and treatment.

Key words: bilirubin; tumor diagnosis; tumor treatment; antioxidation; nanomedicine

Received: 　　Accepted:

Corresponding author: 刘金保　　E-mail:

Citing This Article：

FU Wen, CHEN Xin, XU Wen-Wen, LIU Jin-Bao. The prognostic significance and therapeutic prospects of bilirubin in tumors. Acta Physiol Sin 2024; 76 (5): 737-742 (in Chinese with English abstract).