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Effect of metabolic reprogramming on abdominal aortic aneurysm

WANG Ge, WANG Mei-Li^*

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China

Abstract

Abdominal aortic aneurysm (AAA) is a life-threatening disease that remains undetected until it acutely ruptures. Due to lack of effective pharmaceutic therapies, it is urgent to explore new prevention and treatment strategies. Metabolic reprogramming is a cellular process through which cells change their metabolic patterns to meet material and energy requirements, including glucose metabolism, lipid metabolism and amino acid metabolism. Recently, the regulatory role of metabolic reprogramming in cardiovascular diseases, especially AAA, has attracted significant attention. This review article focuses on the research progress regarding the effects of metabolic reprogramming of vascular smooth muscle cells (VSMCs) and macrophages on the occurrence and development of AAA, especially their roles in major pathological processes such as VSMCs apoptosis and phenotype transformation, extracellular matrix remodeling, oxidative stress, and inflammatory response. The aim is to provide new clues for the mechanism research and clinical treatment of AAA from the perspective of metabolism.

Key words: abdominal aortic aneurysm; metabolic reprogramming; Vascular smooth muscle cell; Macrophage

Received: 　　Accepted:

Corresponding author: 王美丽　　E-mail:

DOI: 10.13294/j.aps.2024.0045

Citing This Article：

WANG Ge, WANG Mei-Li. Effect of metabolic reprogramming on abdominal aortic aneurysm. Acta Physiol Sin 2024; 76 (3): 457-474 (in Chinese with English abstract).