Issue Archive

Progress on the involvement of HDAC11 in the regulation of mammalian oocyte maturation and early embryonic development

SHI Jia-Qi^1,2, LIU Xin-Feng^1,2, WANG Chao^3,*

¹Key Lab of Ministry of Education for Protection and Utilization of Special Biological Resources in the Western China, Ningxia University, Yinchuan 750021, China；²College of Life Sciences, Ningxia University, Yinchuan 750021, China；³State Key Laboratory of Farm Animal Biotech Breeding, China Agricultural University, Beijing 100193, China

Abstract

Oocyte maturation and early embryonic development are key steps in the reproductive physiology of female mammals, and any error in this process can adversely affect reproductive development. Recent studies have shown that epigenetic modifications of histones play important roles in the regulation of oocyte meiosis and quality assurance of early embryonic development. Histone deacetylase 11 (HDAC11) is the smallest known member of the histone deacetylases (HDACs) family, and inhibition of HDAC11 activity significantly suppresses the rate of oocyte maturation, as well as the development of 8-cell and blastocyst embryos at the embryonic stage. This paper focuses on recent progress on the important role of HDAC11 in the regulation of mammalian oocyte maturation and early embryonic development, hoping to gain insights into the key roles played by epitope-modifying proteins represented by HDAC11 in the regulation of mammalian reproduction and their molecular mechanisms.

Key words: oocyte; early embryo; mammalian; HDAC11

Received: 　　Accepted:

Corresponding author: 王超　　E-mail:

DOI: 10.13294/j.aps.2024.0030

Citing This Article：

SHI Jia-Qi, LIU Xin-Feng, WANG Chao. Progress on the involvement of HDAC11 in the regulation of mammalian oocyte maturation and early embryonic development. Acta Physiol Sin 2024; 76 (3): 438-446 (in Chinese with English abstract).