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Transition metal accumulation and cellular senescence

XIE An-Na, LIU Guo-Yi, ZHANG Sun-Zhengyuan, DAI Wei-Wei^*

Laboratory of Science and Technology Center, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China

Abstract

Aging refers to a progressive decline in biological functions, leading to age-related diseases and mortality. The transition metals, including iron, copper, and manganese, play important roles in human physiological and pathological processes. Substantial research has demonstrated that senescent cells accumulate higher levels of transition metals, which in turn accelerates the process of cellular senescence and related diseases through mechanisms such as production of excessive reactive oxygen species (ROS), induction of oxidative stress, DNA damage, and mitochondrial dysfunction. This review article provides a comprehensive overview of the causes of transition metal accumulation in senescent cells, as well as the mechanisms by which it further promotes cellular senescence and related diseases. The aim is to provide insights into anti-aging and treatment of aging-related diseases caused by transition metal accumulation.

Key words: Cellular senescence; transition metal accumulation; reactive oxygen species; oxidative stress; mitochondrial function

Received: 　　Accepted:

Corresponding author: 戴薇薇　　E-mail:

DOI: 10.13294/j.aps.2024.0032

Citing This Article：

XIE An-Na, LIU Guo-Yi, ZHANG Sun-Zhengyuan, DAI Wei-Wei. Transition metal accumulation and cellular senescence. Acta Physiol Sin 2024; 76 (3): 418-428 (in Chinese with English abstract).