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Research progress of microRNA in spinal cord injury

WEI Dong-Min¹, FANG Rui², DENG Zhi-Zhong¹, BAI Xin-Yue¹, ZHU Jing-Hui¹, ZHAI Tian-Yu¹, ZHANG Can¹, GAO Jian-Zhong³, SU Dan¹, YANG Yan-Ling¹, ZHAO Lin^1,*

¹Medical College of Yan’an University, Yan’an 716000, China；²Department of Imaging, Dezhou Second People’s Hospital, Dezhou 254300, China；³Neurosurgery Department of Yulin First People’s Hospital, Yulin 719000, China

Abstract

Spinal cord injury (SCI) is a serious central nervous system disease with high disability and mortality rates and complex pathophysiologic mechanisms. MicroRNA (miRNA), as a kind of non-coding RNA, plays an important role in SCI. miRNA is involved in the regulation of inflammatory response, oxidative stress, axonal regeneration, and apoptosis after SCI, and interacts with long non-coding RNA (lncRNA) and circular RNA (circRNA) to regulate the pathophysiological process of SCI. This paper summarizes the changes in miRNA expression after SCI, and reviews the targeting mechanism of miRNA in SCI and the current research status of miRNA-targeted drugs to provide new targets and new horizons for basic and clinical research on SCI.

Key words: spinal cord injury; microRNA; inflammatory response; oxidative stress; axonal regeneration; apoptosis; autophagy; ferroptosis

Received: 　　Accepted:

Corresponding author: 赵琳　　E-mail:

DOI: 10.13294/j.aps.2024.0026

Citing This Article：

WEI Dong-Min, FANG Rui, DENG Zhi-Zhong, BAI Xin-Yue, ZHU Jing-Hui, ZHAI Tian-Yu, ZHANG Can, GAO Jian-Zhong, SU Dan, YANG Yan-Ling, ZHAO Lin. Research progress of microRNA in spinal cord injury. Acta Physiol Sin 2024; 76 (3): 394-406