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Research progress of PD-L1 in inflammatory lung diseases

LI A-Guo^1,2, CAI Ai-Hua^1,2, LI Hao-Ji^1,3, HUANG Qi-Yin^1,2, TU Yong-Sheng^1,4,*

¹Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, Guangzhou 511436, China；²The Second Clinical College, Guangzhou Medical University, Guangzhou 511436, China；³The Third Clinical College, Guangzhou Medical University, Guangzhou 511436, China；⁴Department of Physiology, College of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China

Abstract

Programmed death-ligand 1 (PD-L1) is important in maintaining central and peripheral immune tolerance in normal tissues, mediating tumor immune escape and keeping the balance between anti- and pro-inflammatory responses. Inflammation plays an important role in inflammatory lung diseases. This article reviews the research progress and potential clinical value of PD-L1 in inflammatory lung diseases, including acute lung injury, chronic obstructive pulmonary disease, asthma and idiopathic pulmonary fibrosis.

Key words: programmed death-ligand 1; acute lung injury; chronic obstructive pulmonary disease; asthma; idiopathic pulmonary fibrosis

Received: 　　Accepted:

Corresponding author: 涂永生　　E-mail: tuys@gzhmu.edu.cn

DOI: 10.13294/j.aps.2024.0013

Citing This Article：

LI A-Guo, CAI Ai-Hua, LI Hao-Ji, HUANG Qi-Yin, TU Yong-Sheng. Research progress of PD-L1 in inflammatory lung diseases. Acta Physiol Sin 2024; 76 (2): 346-352 (in Chinese with English abstract).