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Advances in the study of the actin nucleation factor Spire

PANG Tao, ZHANG Li-Xia, BAI An-Na, YANG Wen, HAO Li-Xia^*

Department of Rehabilitation Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China

Abstract

There are three main classes of actin nucleation factors: Arp2/3 complexes, Spire and Formin. Spire assembles microfilaments by nucleating stable longitudinal tetramers and binding actin to the growing end of the microfilament. As early as 1999, Wellington et al. identified Spire as an actin nucleating agent, however, over the years, most studies have focused on Arp2/3 and Formin proteins; there has been relatively less research on Spire as a member of the actin nucleating factors. Recent studies have shown that Spire is involved in the vesicular transport through the synthesis of actin and plays an important role in neural development. In this paper, we reviewed the structure, expression and function of Spire, and its association with disease in order to identify meaningful potential directions for studies on Spire.

Key words: actin nucleation factors; Spire-2; neuron

Received: 　　Accepted:

Corresponding author: 郝利霞　　E-mail: haolixia15@163.com

DOI: 10.13294/j.aps.2024.0021

Citing This Article：

PANG Tao, ZHANG Li-Xia, BAI An-Na, YANG Wen, HAO Li-Xia. Advances in the study of the actin nucleation factor Spire. Acta Physiol Sin 2024; 76 (2): 341-345 (in Chinese with English abstract).