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Research progress of non-coding RNA involved in glycolysis regulation of hepatocellular carcinoma

HU Xiao-Feng^1,2, ZHANG Qing^1,2, LIANG Mei-Lv^1,2, ZHOU Qing-Niao^1,2, ZHAO Rui-Qiang^1,2, GONG Zu-Kang³, LIN Wen-Zhen^1,2,*

¹Department of Biochemistry and Molecular Biology, School of Basic Medicine, Guangxi Medical University, Nanning 530021, China；²Laboratory of Biological Molecular Medicine Research (Guangxi Medical University), Education Department of Guangxi Zhuang Autonomous Region, Nanning 530021, China；³Nanning Center for Disease Control and Prevention, Nanning 530021, China

Abstract

Liver cancer is a common tumor of digestive system. Hepatocellular carcinoma (HCC) is a common type of liver cancer, which has a high degree of malignancy and ranks among the top causes of cancer-related death in the world. Metabolic reprogramming is considered to be an important marker of carcinogenesis. Glucose metabolism is one of the main ways for cells to produce energy. Glycolysis, as the basic reaction of glucose metabolism, plays an important role in cell metabolism. Therefore, the regulation of glycolysis is of great significance to the proliferation and evolution of tumors. More and more non-coding RNAs (ncRNA) have been proved to play an important role in the regulation of tumor glycolysis. This article reviews the role of ncRNA in the regulation of HCC glycolysis and its related mechanisms. At the same time, the prospect of targeted therapy for HCC based on the related mechanisms of glycolysis regulation is put forward.

Key words: hepatocellular carcinoma; non-coding RNA; glucose metabolism reprogramming; glycolysis regulation

Received: 　　Accepted:

Corresponding author: 林文珍　　E-mail: linwenzhen@msn.com

DOI: 10.13294/j.aps.2024.0018

Citing This Article：

HU Xiao-Feng, ZHANG Qing, LIANG Mei-Lv, ZHOU Qing-Niao, ZHAO Rui-Qiang, GONG Zu-Kang, LIN Wen-Zhen. Research progress of non-coding RNA involved in glycolysis regulation of hepatocellular carcinoma. Acta Physiol Sin 2024; 76 (2): 319-328 (in Chinese with English abstract).