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Research progress on the neural mechanism of the regulation of social isolation  on innate behaviors 

ZHAO Jia-Ying, JI Xiao-Xiao, PAN Yu-Feng, CHEN Jie^*

School of Life Science and Technology, Southeast University, Nanjing 210096, China

Abstract

Innate behavior is mainly controlled by genetics, but is also regulated by social experiences such as social isolation. Studies in animal models such as Drosophila and mice have found that social isolation can regulate innate behaviors through the changes at the molecular level, such as hormone, neurotransmitter, neuropeptide level, and at the level of neural circuits. In this review, we summarized the research progress on the regulation of social isolation on various animal innate behaviors, such as sleep, reproduction and aggression by altering the expression of conserved neuropeptides and neurotransmitters, hoping to deepen the understanding of the key and conserved signal pathways that regulate innate behavior by social isolation. 

Key words: social isolation; innate behavior; neuropeptide; neurotransmitter

Received: 　　Accepted:

Corresponding author: 陈洁　　E-mail: 101300128@seu.edu.cn

DOI: 10.13294/j.aps.2024.0019

Citing This Article：

ZHAO Jia-Ying, JI Xiao-Xiao, PAN Yu-Feng, CHEN Jie. Research progress on the neural mechanism of the regulation of social isolation  on innate behaviors . Acta Physiol Sin 2024; 76 (2): 309-318 (in Chinese with English abstract).