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Research progress on the role of microglia in sepsis-associated encephalopathy

LONG Lu-Hong, CAO Wen-Yu, XU Yang, XIANG Yu-Yan^*

Reproductive Medicine Application Institute, Hengyang Medical School, University of South China, Hengyang 421001, China

Abstract

Sepsis-associated encephalopathy (SAE) refers to diffuse brain dysfunction caused by sepsis, which is characterized by decreased attention, directional impairment, being prone to irritation, and in severe cases the patient will experience drowsiness and coma. The pathogenesis of SAE mainly includes neuroinflammation, damage of blood-brain barrier, cerebral vascular dysfunction, and neurometabolic changes, among which neuroinflammation is the core pathological process. Microglia are considered to be important immune cells of the central nervous system and play an important role in neuroinflammation. This article systematically describes the role of microglia in the development of SAE, and discusses the phenotype and related signaling pathways of microglia, in order to clarify the role of microglia in SAE and provide a theoretical basis for clinical treatment of SAE.

Key words: sepsis-associated encephalopathy; sepsis; microglia; neuroinflammation

Received: 　　Accepted:

Corresponding author: 向宇燕　　E-mail: beijiashan6887@126.com

DOI: 10.13294/j.aps.2024.0016

Citing This Article：

LONG Lu-Hong, CAO Wen-Yu, XU Yang, XIANG Yu-Yan. Research progress on the role of microglia in sepsis-associated encephalopathy. Acta Physiol Sin 2024; 76 (2): 289-300 (in Chinese with English abstract).