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Research progress on the regulatory mechanisms of Irisin on cognitive dysfunction in patients with Alzheimer's disease and the interventional role of Irisin in associated diseases

LAN Tian, GUO Zong-Cheng, GU Hao-Ran, QIN Lu, HE En-Peng^*

School of Physical Education, Xinjiang Normal University, Urumqi 830000, China

Abstract

Irisin, a peptide produced during exercise, is believed to play a role in regulating energy levels within the body. Moreover, Irisin has the ability to traverse the blood-brain barrier and engage in various pathophysiological processes within the central nervous system. An increasing body of research identifies Irisin as a significant therapeutic target for neurodegenerative diseases, indicating a strong link between Irisin and the development of cognitive impairments. In this paper, we present a concise review of effects of different types of exercise on Irisin production, and the mechanisms underlying the Irisin’s intervention in various diseases including metabolic diseases, kidney injury and depression. Following this, we delve into an in-depth exploration of its role in modulating cognitive dysfunction among patients with Alzheimer’s disease (AD), focusing on recent advancements in three critical areas: neuroinflammation, mitochondrial dysfunction, and protein misfolding. Finally, we put forth 3 hypotheses: (1) exercise-induced fibronectin type III domain containing protein 5 (FNDC5) stimulation and subsequent Irisin cleavage may be associated with the stress response in energy metabolism; (2) Irisin, as a myokine, likely plays a role in mitochondrial repair mechanisms to ameliorate cognitive impairment in AD patients; (3) Irisin is a homeostatic factor that maintains energy homeostasis and is closely related to the dynamic stability of the body’s internal environment.

Key words: irisin; exercise; cognitive dysfunction; energy homeostasis; Alzheimer’s disease; neurodegeneration

Received: 　　Accepted:

Corresponding author: 何恩鹏　　E-mail: heenpeng@sina.com

DOI: 10.13294/j.aps.2024.0020

Citing This Article：

LAN Tian, GUO Zong-Cheng, GU Hao-Ran, QIN Lu, HE En-Peng. Research progress on the regulatory mechanisms of Irisin on cognitive dysfunction in patients with Alzheimer's disease and the interventional role of Irisin in associated diseases. Acta Physiol Sin 2024; 76 (2): 266-288