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Research advances of prostaglandin E₂ receptor 1 (EP1)

CHEN Shu-Tao¹, JI Shuang², GUO Mei-Na², CHEN Li-Hong^2,*

¹College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China；²Advanced Institute for Medical Sciences, Dalian Medical University, Dalian 116044, China

Abstract

Prostaglandin E2 (PGE2) is an important lipid molecule derived from arachidonic acid, which regulates a variety of physiological and pathological activities. Based on the inhibition of inflammatory PGE2 production, non-steroidal anti-inflammatory drugs (NSAIDs) are considered as the most commonly used drugs to treat inflammatory diseases and to relieve fever and pain symptoms. PGE2 mediates its functions via four different G protein-coupled receptors, named EP1–EP4. Though the limited distribution and low PGE2 affinity of EP1, it plays important roles in the maintenance of many physiological functions and homeostasis. Moreover, EP1 is widely involved in the inflammatory response, pain perception and multisystem pathological function regulation. In this review, we will briefly summarize the recent advances on the physiological and pathophysiological function of EP1 and its targeted drugs development.

Key words: prostaglandin E2; EP1; inflammation

Received: 　　Accepted:

Corresponding author: 陈丽红　　E-mail: lihong@dmu.edu.cn

DOI: 10.13294/j.aps.2024.0007

Citing This Article：

CHEN Shu-Tao, JI Shuang, GUO Mei-Na, CHEN Li-Hong. Research advances of prostaglandin E₂ receptor 1 (EP1). Acta Physiol Sin 2024; 76 (1): 105-118 (in Chinese with English abstract).