Issue Archive

Research progress of trace amine-associated receptor 1 signaling pathways

SUN Meng, ZHANG Chen-Chen, LI Ji-Tao, SI Tian-Mei, SU Yun-Ai^*

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing 100191, China

Abstract

Trace amine-associated receptor 1 (TAAR1) is a classical type of G-protein-coupled receptor, which is widely distributed in the brain of mammals, especially in the limbic system and the region rich in monoaminergic neurons, and it is a highly conserved TAAR subtype in all species. TAAR1 can specifically respond to endogenous trace amines in the central nervous system and peripheral tissues, and plays an important role in the pathophysiological mechanisms involving the dysregulation of monoamine system and glutamate system leading to mental disorders. In addition, TAAR1 modulator can act on inwardly rectifying potassium channels and regulate synaptic transmission and neuronal activity. According to the latest research findings, TAAR1 exerts a series of functions by regulating signal pathways and substrate phosphorylation, which is related to emotion, cognition, fear and addiction. Therefore, we conducted a detailed review of relevant studies on the TAAR1 signaling pathways, aiming at revealing the great potential of TAAR1 as a new target for drug treatment of neuropsychiatric disorders.

Key words: trace amine-associated receptor 1; signaling pathway; monoamine system; glutamate system; inwardly rectifying potassium channel

Received: 　　Accepted:

Corresponding author: 苏允爱　　E-mail: suyunai@bjmu.edu.cn

DOI: 10.13294/j.aps.2023.0072

Citing This Article：

SUN Meng, ZHANG Chen-Chen, LI Ji-Tao, SI Tian-Mei, SU Yun-Ai. Research progress of trace amine-associated receptor 1 signaling pathways. Acta Physiol Sin 2024; 76 (1): 89-96 (in Chinese with English abstract).