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Traditional Chinese medicine used as anti-aging agent by targeting nuclear factor erythroid 2-related factor 2 signaling pathway

XU Jia-Yi¹, YAN Liang-Wen¹, TANG Shen-Kang^1,2, LIU Peng-Fei^1,*

¹National and Local Joint Engineering Research Center for Biological Diagnosis and Treatment, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China；²Department of Oncology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China

Abstract

The imbalance of redox homeostasis is a major characteristic of aging and contributes to the pathogenesis of various aging-related diseases. As a regulatory hub of redox homeostasis, nuclear factor erythroid 2-related factor 2 (NRF2) can attenuate oxidative stress by activating the transcription of many antioxidant enzymes. China is the birthplace of traditional Chinese medicine (TCM) which has been wildly used as medicine for thousands of years. Recently, TCM as anti-aging medicine has attracted enormous attention. Focusing on the NRF2 signaling pathway, this paper summarizes the correlation between various anti-aging TCM and the NRF2 signaling, and discusses the common key mechanisms by which TCM slows the aging process by targeting the NRF2 signaling network.

Key words: nuclear factor erythroid 2-related factor 2; Chinese medicine; anti-aging; herb monomer

Received: 　　Accepted:

Corresponding author: 刘朋飞　　E-mail: liupengfei@xjtu.edu.cn

DOI: 10.13294/j.aps.2023.0078

Citing This Article：

XU Jia-Yi, YAN Liang-Wen, TANG Shen-Kang, LIU Peng-Fei. Traditional Chinese medicine used as anti-aging agent by targeting nuclear factor erythroid 2-related factor 2 signaling pathway. Acta Physiol Sin 2023; 75 (6): 877-886 (in Chinese with English abstract).