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Research progress in drugs targeting 5-lipoxygenase for age-related diseases

LI Zhi-Jun^1,2, MA Yan-Hui^1,2, HOU Xi-Xi³, YAO Tuan-Li¹, QIN Xiang-Yang^2,*

¹School of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China；²Department of Chemistry, School of Pharmacy, Air Force Medical University, Xi’an 710032, China；³College of Life Science, Northwestern University, Xi’an 710068, China

Abstract

With the acceleration of aging society, delaying aging or promoting healthy aging has become a major demand for human health. 5-Lipoxygenase (5-LOX) is a key enzyme catalyzing arachidonic acid into leukotrienes (LTs), which is a potent mediator of the inflammatory response. Previous studies showed that abnormal activation of 5-LOX and overproduction of LTs are closely related to the occurrence and development of aging-related inflammatory diseases. Therefore, inhibiting 5-LOX activation is a possibly potential strategy for treating age-related diseases. In this paper, the latest research progress in 5-LOX activation, 5-LOX in mediating aging- related diseases and its small molecule inhibitors is briefly reviewed to provide scientific theoretical basis and new ideas for the prevention and treatment of aging-related inflammatory diseases.

Key words: Aging; inflamm-aging; age-related disease; 5-lipoxygenase; 5-lipoxygenase inhibitor

Received: 　　Accepted:

Corresponding author: 秦向阳　　E-mail: qinxiangyang@fmmu.edu.cn

DOI: 10.13294/j.aps.2023.0075

Citing This Article：

LI Zhi-Jun, MA Yan-Hui, HOU Xi-Xi, YAO Tuan-Li, QIN Xiang-Yang. Research progress in drugs targeting 5-lipoxygenase for age-related diseases. Acta Physiol Sin 2023; 75 (6): 864-876 (in Chinese with English abstract).