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Advances in live-imaging aging reporter mice

SUN Jie^1,2, WANG Yu-Ning³, LUO Shan-Shan⁴, LIU Bao-Hua^1,2,*

¹School of Basic Medical Science, Shenzhen University, Shenzhen 518060, China；²Shenzhen Key Laboratory for Systemic Aging and Intervention (SKL-SAI), Shenzhen 518060, China；³Clinical Trial Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China；⁴Luohu Clinical Institute of Shantou University Medical College, Shenzhen 518005, China

Abstract

Aging is an independent risk factor for chronic diseases in the elderly, and understanding aging mechanisms is one of the keys to achieve early prevention and effective intervention for the diseases. Aging process is dynamic and systemic, making it difficult for mechanistic study. With recent advances in aging biomarkers and development of live-imaging technologies, more and more reporter mouse models have been generated, which can live monitor the aging process, and help investigate aging mechanisms at systemic level and develop intervention strategies. This review summarizes recent advances in live-imaging aging reporter mouse models based on widely used aging biomarkers (p16^Ink4a, p21^Waf1/Cip1, p53 and Glb1), and discusses their applications in aging research.

Key words: Aging; live-imaging reporter mice; p16INK4a; p21Waf1/Cip1; p53; Glb1

Received: 　　Accepted:

Corresponding author: 刘宝华　　E-mail: ppliew@szu.edu.cn

DOI: 10.13294/j.aps.2023.0079

Citing This Article：

SUN Jie, WANG Yu-Ning, LUO Shan-Shan, LIU Bao-Hua. Advances in live-imaging aging reporter mice. Acta Physiol Sin 2023; 75 (6): 836-846 (in Chinese with English abstract).