Issue Archive

The role of mitochondria-associated endoplasmic reticulum membranes in age-related cardiovascular diseases

ZHANG Yu¹, ZHAO Xin-Yi¹, XIE Wen-Jun², ZHANG Yi^1,*

¹Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an 710061, China；²Department of Cardiology, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China

Abstract

Mitochondria-associated endoplasmic reticulum membranes (MAMs) are the physical connection sites between mitochondria and endoplasmic reticulum (ER). As the compartments controlling substance and information communications between ER and mitochondria, MAMs were involved in the regulation of various pathophysiological processes, such as calcium homeostasis, mitochondrial morphology and function, lipid metabolism and autophagy. In the past decades, accumulating lines of evidence have revealed the pivotal role of MAMs in diverse cardiovascular diseases (CVD). Aging is one of the major independent risk factors for CVD, which causes progressive degeneration of the cardiovascular system, leading to increased morbidity and mortality of CVD. This review aims to summarize the research progress of MAMs in age-related CVD, and explore new targets for its prevention and treatment.

Key words: mitochondrial-associated endoplasmic reticulum membranes (MAMs); age-related cardiovascular diseases; calcium homeostasis; lipid metabolism; autophagy

Received: 　　Accepted:

Corresponding author: 张伊　　E-mail: zhangyixjtu@xjtu.edu.cn

DOI: 10.13294/j.aps.2023.0081

Citing This Article：

ZHANG Yu, ZHAO Xin-Yi, XIE Wen-Jun, ZHANG Yi. The role of mitochondria-associated endoplasmic reticulum membranes in age-related cardiovascular diseases. Acta Physiol Sin 2023; 75 (6): 799-816 (in Chinese with English abstract).